Basic Information:

  VIRBase ID:  

VHID00510680

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7903

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          MRPS2:  NR_051969     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	MRPS2
miRBase Accession/Entrez ID	MIMAT0001581	51116
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	CGI-91//COXPD36//MRP-S2//S2mt

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MRPS2	chr9:138392530-138392531(+) m6A 5'UTR       24284625//24981863 chr9:138392808-138392809(+) m6A CDS//intron       24981863 chr9:138392821-138392822(+) m6A CDS//intron       24981863 chr9:138392960-138392961(+) m6A CDS//exon       - chr9:138393035-138393036(+) m6A exon//intron       - chr9:138394103-138394104(+) m6A exon//intron       24284625 chr9:138394439-138394440(+) m6A exon//intron       24284625 chr9:138394449-138394450(+) m6A exon//intron       24284625 chr9:138394458-138394459(+) m6A exon//intron       24284625 chr9:138395422-138395423(+) m6A CDS//exon       24284625//24209618//24981863//26404942//22575960//22608085 chr9:138395444-138395445(+) m6A CDS//exon       24284625//24209618//24981863//26404942//22575960//22608085 chr9:138395476-138395477(+) m6A CDS//exon       24284625//24209618//24981863//26404942//22575960//22608085 chr9:138395557-138395558(+) m6A CDS//exon       24284625//24209618//24981863//26404942//22575960//22608085 chr9:138395659-138395660(+) m6A CDS//exon       24284625//24209618//24981863//26404942//22575960//22608085 chr9:138395734-138395735(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:138395758-138395759(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:138395929-138395930(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:138396002-138396003(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:138396102-138396103(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:138396124-138396125(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:138396140-138396141(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:138396174-138396175(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:138396229-138396230(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:138396458-138396459(+) m6A 3'UTR       24284625//24981863//27773535 chr9:138396496-138396497(+) m6A 3'UTR       24284625//24981863//27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	MRPS2	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleolus K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells     - Ribosome-free cytosol Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: MRPS2

Evidence Support:

Strong-Evidence	RISC-IP
Prediction-Evidence	miRanda//RNAHybrid
Support Database	ViRBase//VmiReg

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.