Basic Information:

  VIRBase ID:  

VHID00510579

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7903

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          CDON:  NM_016952     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	CDON
miRBase Accession/Entrez ID	MIMAT0001581	50937
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	CDO//CDON1//HPE11//ORCAM

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CDON	chr11:125835970(-) A-I      intronic chr11:125840234(-) A-I      intronic chr11:125843902(-) A-I      intronic chr11:125835972(-) A-I      intronic chr11:125835969(-) A-I      intronic chr11:125843962(-) A-I      intronic chr11:125840185(-) A-I      intronic chr11:125918095(-) A-I      intronic chr11:125843305(-) A-I      intronic chr11:125843165(-) A-I      intronic chr11:125918164(-) A-I      intronic chr11:125843955(-) A-I      intronic chr11:125834898(-) A-I      intronic chr11:125854492(-) A-I      intronic chr11:125835773(-) A-I      intronic chr11:125840324(-) A-I      intronic chr11:125843183(-) A-I      intronic chr11:125842201(-) A-I      intronic chr11:125843928(-) A-I      intronic chr11:125843876(-) A-I      intronic chr11:125835099(-) A-I      intronic chr11:125843400(-) A-I      intronic chr11:125840274(-) A-I      intronic chr11:125907166(-) A-I      intronic chr11:125843364(-) A-I      intronic chr11:125843363(-) A-I      intronic chr11:125917937(-) A-I      intronic chr11:125835098(-) A-I      intronic chr11:125843343(-) A-I      intronic chr11:125858356(-) A-I      intronic chr11:125855250(-) A-I      intronic chr11:125835864(-) A-I      intronic chr11:125834912(-) A-I      intronic chr11:125843278(-) A-I      intronic chr11:125855146(-) A-I      intronic chr11:125843964(-) A-I      intronic chr11:125843228(-) A-I      intronic chr11:125840230(-) A-I      intronic chr11:125858360(-) A-I      intronic chr11:125843184(-) A-I      intronic chr11:125837782(-) A-I      intronic chr11:125842276(-) A-I      intronic chr11:125844072(-) A-I      intronic chr11:125842240(-) A-I      intronic chr11:125840208(-) A-I      intronic chr11:125830179(-) A-I      3'UTR chr11:125835988(-) A-I      intronic chr11:125840340(-) A-I      intronic chr11:125912764(-) A-I      intronic chr11:125835867(-) A-I      intronic chr11:125871168(-) A-I      intronic chr11:125855249(-) A-I      intronic chr11:125843215(-) A-I      intronic chr11:125835825(-) A-I      intronic chr11:125837608(-) A-I      intronic chr11:125835993(-) A-I      intronic chr11:125907165(-) A-I      intronic chr11:125882448(-) A-I      intronic chr11:125837783(-) A-I      intronic chr11:125842308(-) A-I      intronic chr11:125855248(-) A-I      intronic chr11:125837765(-) A-I      intronic chr11:125840252(-) A-I      intronic chr11:125843893(-) A-I      intronic chr11:125835847(-) A-I      intronic chr11:125907211(-) A-I      intronic chr11:125852048(-) A-I      intronic chr11:125843863(-) A-I      intronic chr11:125842211(-) A-I      intronic chr11:125907164(-) A-I      intronic chr11:125840314(-) A-I      intronic chr11:125843171(-) A-I      intronic chr11:125855370(-) A-I      intronic chr11:125843238(-) A-I      intronic chr11:125834986(-) A-I      intronic chr11:125894931(-) A-I      intronic chr11:125837835(-) A-I      intronic chr11:125837841(-) A-I      intronic chr11:125837836(-) A-I      intronic chr11:125837648(-) A-I      intronic chr11:125855239(-) A-I      intronic chr11:125918854(-) A-I      intronic chr11:125840207(-) A-I      intronic chr11:125842174(-) A-I      intronic chr11:125837815(-) A-I      intronic chr11:125835785(-) A-I      intronic chr11:125837849(-) A-I      intronic chr11:125835053(-) A-I      intronic chr11:125835078(-) A-I      intronic chr11:125840135(-) A-I      intronic chr11:125837876(-) A-I      intronic chr11:125844063(-) A-I      intronic chr11:125852047(-) A-I      intronic chr11:125835019(-) A-I      intronic chr11:125918102(-) A-I      intronic chr11:125915085(-) A-I      intronic chr11:125921628(-) A-I      intronic chr11:125843246(-) A-I      intronic chr11:125843412(-) A-I      intronic chr11:125837781(-) A-I      intronic chr11:125843858(-) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CDON	chr11:125827429-125827430(-) m6A 3'UTR       27773535 chr11:125828597-125828598(-) m6A 3'UTR       24981863 chr11:125828612-125828613(-) m6A 3'UTR       24981863 chr11:125829330-125829331(-) m6A 3'UTR       24981863 chr11:125829370-125829371(-) m6A 3'UTR       24981863 chr11:125829856-125829857(-) m6A 3'UTR       27773535//22608085 chr11:125829871-125829872(-) m6A 3'UTR       27773535//22608085 chr11:125830045-125830046(-) m6A 3'UTR       24284625//24981863//27773535//22608085 chr11:125830091-125830092(-) m6A 3'UTR       22608085 chr11:125830102-125830103(-) m6A 3'UTR       22608085 chr11:125830755-125830756(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22608085 chr11:125830767-125830768(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22608085 chr11:125830825-125830826(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr11:125830833-125830834(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr11:125830841-125830842(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr11:125830876-125830877(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22608085 chr11:125830907-125830908(-) m6A CDS       24284625//25456834//24981863//22608085 chr11:125830976-125830977(-) m6A CDS       25456834//22608085 chr11:125830996-125830997(-) m6A CDS       25456834//22608085 chr11:125850964-125850965(-) m6A CDS       - chr11:125850981-125850982(-) m6A CDS       - chr11:125864822-125864823(-) m6A CDS       27773535 chr11:125875729-125875730(-) m6A 3'UTR//CDS       - chr11:125875742-125875743(-) m6A 3'UTR//CDS       - chr11:125875862-125875863(-) m6A 3'UTR//CDS       24284625 chr11:125880766-125880767(-) m6A 3'UTR//intron       22608085 chr11:125885104-125885105(-) m6A exon//intron       24981863//22608085 chr11:125885151-125885152(-) m6A CDS//exon       24981863//22608085 chr11:125885241-125885242(-) m6A CDS//exon       24284625//24981863//27371828//22608085 chr11:125885320-125885321(-) m6A CDS//exon       22608085 chr11:125889523-125889524(-) m6A CDS//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	CDON	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Membrane HCC cell line (HepG2)     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: CDON

Evidence Support:

Strong-Evidence	RISC-IP
Prediction-Evidence	miRanda//Targetscan
Support Database	ViRBase//VmiReg

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.