Detail Information

Basic Information:


  VIRBase ID:  

VHID00510541

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           GEMIN4:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p GEMIN4
miRBase
Accession/Entrez ID		 MIMAT0001581 50628
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - HC56//HCAP1//HHRF-1//NEDMCR//p97

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR GEMIN4
chr17:653433(-) A-I      intronic
chr17:653361(-) A-I      intronic
chr17:653407(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED GEMIN4
chr17:653361(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase GEMIN4
chr17:647702-647703(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr17:647744-647745(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr17:647760-647761(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr17:647889-647890(-) m6A 3'UTR       24284625//24209618//24981863//28052920//27773535//22575960//22608085
chr17:647958-647959(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//22575960//22608085
chr17:647976-647977(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//22575960//22608085
chr17:647991-647992(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr17:648134-648135(-) m6A CDS       24284625//24209618//24981863//26404942//27371828//27773536//22575960//22608085
chr17:648230-648231(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr17:648242-648243(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr17:648260-648261(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr17:648373-648374(-) m6A CDS       24284625//24981863//26404942//27773535//22575960//22608085
chr17:648384-648385(-) m6A CDS       24284625//25456834//24981863//26404942//27773535//22575960//22608085
chr17:648427-648428(-) m6A CDS       24284625//25456834//24981863//26404942//22575960//22608085
chr17:648459-648460(-) m6A CDS       24284625//25456834//24981863//22575960//22608085
chr17:648472-648473(-) m6A CDS       24284625//25456834//24981863//22575960//22608085
chr17:648530-648531(-) m6A CDS       24284625//24981863//22575960//22608085
chr17:648648-648649(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27371828//22575960//22608085
chr17:648741-648742(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27371828//27773536//22575960//22608085
chr17:648878-648879(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr17:648977-648978(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr17:648982-648983(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr17:648990-648991(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr17:649046-649047(-) m6A CDS       24284625//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr17:649165-649166(-) m6A CDS       24284625//24981863//22575960//22608085
chr17:649211-649212(-) m6A CDS       24284625//24981863//22575960//22608085
chr17:649253-649254(-) m6A CDS       24284625//24981863//22575960//22608085
chr17:649279-649280(-) m6A CDS       24284625//24981863//22608085
chr17:649374-649375(-) m6A CDS       24284625//22608085
chr17:649396-649397(-) m6A CDS       24284625
chr17:649665-649666(-) m6A CDS       24284625//22575960
chr17:649708-649709(-) m6A CDS       24284625//22575960
chr17:649816-649817(-) m6A CDS       24284625//25456834//24981863//27773535//22575960//22608085
chr17:649904-649905(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr17:649927-649928(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr17:649994-649995(-) m1A 3'UTR//CDS       26863410//26863196
chr17:650035-650036(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr17:650095-650096(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr17:650128-650129(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr17:650167-650168(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr17:650191-650192(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr17:650261-650262(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr17:650348-650349(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr17:650361-650362(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr17:650446-650447(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr17:650452-650453(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr17:650482-650483(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr17:650665-650666(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr17:650755-650756(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr17:650844-650845(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr17:650862-650863(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr17:650913-650914(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr17:650998-650999(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr17:651014-651015(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr17:651262-651263(-) m6A 5'UTR//CDS       24284625//25456834//24981863//22608085
chr17:651270-651271(-) m6A 5'UTR//CDS       24284625//25456834//24981863//22608085
chr17:651313-651314(-) m6A 5'UTR//intron       24284625//25456834//24981863//22608085
chr17:651350-651351(-) m6A 5'UTR//intron       24284625//25456834//24981863
chr17:651366-651367(-) m6A 5'UTR//intron       24284625//24981863
chr17:651791-651792(-) m6A 5'UTR//intron       24284625
chr17:655265-655266(-) m6A 5'UTR//intron       24284625//24981863
chr17:655377-655378(-) m6A 5'UTR//CDS//intron       24284625//24981863
chr17:655859-655860(-) m6A 5'UTR//intron       24284625//24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate GEMIN4
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Colon cancer cells     24393600
Nucleus HeLa-S3 cells     -
Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: GEMIN4

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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