Basic Information:

  VIRBase ID:  

VHID00510537

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          ITSN2:  NM_001348182     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	ITSN2
miRBase Accession/Entrez ID	MIMAT0001581	50618
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	PRO2015//SH3D1B//SH3P18//SWA//SWAP

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ITSN2	chr2:24479982(-) A-I      intronic chr2:24517173(-) A-I      intronic chr2:24517195(-) A-I      intronic chr2:24539246(-) A-I      intronic chr2:24480418(-) A-I      intronic chr2:24517233(-) A-I      intronic chr2:24517232(-) A-I      intronic chr2:24517208(-) A-I      intronic chr2:24539261(-) A-I      intronic chr2:24539278(-) A-I      intronic chr2:24539242(-) A-I      intronic chr2:24453574(-) A-I      intronic chr2:24539288(-) A-I      intronic chr2:24487231(-) A-I      intronic chr2:24489615(-) A-I      intronic chr2:24489746(-) A-I      intronic chr2:24490568(-) A-I      intronic chr2:24490595(-) A-I      intronic chr2:24490625(-) A-I      intronic chr2:24498168(-) A-I      intronic chr2:24517077(-) A-I      intronic chr2:24517219(-) A-I      intronic chr2:24518305(-) A-I      intronic chr2:24518386(-) A-I      intronic chr2:24518391(-) A-I      intronic chr2:24518405(-) A-I      intronic chr2:24528254(-) A-I      intronic chr2:24528259(-) A-I      intronic chr2:24528878(-) A-I      intronic chr2:24528911(-) A-I      intronic chr2:24528914(-) A-I      intronic chr2:24528921(-) A-I      intronic chr2:24529009(-) A-I      intronic chr2:24529115(-) A-I      intronic chr2:24550312(-) A-I      intronic chr2:24550341(-) A-I      intronic chr2:24550345(-) A-I      intronic chr2:24550346(-) A-I      intronic chr2:24550392(-) A-I      intronic chr2:24550395(-) A-I      intronic chr2:24479968(-) A-I      intronic chr2:24479981(-) A-I      intronic chr2:24480033(-) A-I      intronic chr2:24550423(-) A-I      intronic chr2:24554963(-) A-I      intronic chr2:24555003(-) A-I      intronic chr2:24556794(-) A-I      intronic chr2:24557035(-) A-I      intronic chr2:24480089(-) A-I      intronic chr2:24480106(-) A-I      intronic chr2:24564579(-) A-I      intronic chr2:24480184(-) A-I      intronic chr2:24480464(-) A-I      intronic chr2:24557110(-) A-I      intronic chr2:24480499(-) A-I      intronic chr2:24480502(-) A-I      intronic chr2:24480504(-) A-I      intronic chr2:24479942(-) A-I      intronic chr2:24557131(-) A-I      intronic chr2:24557183(-) A-I      intronic chr2:24557194(-) A-I      intronic chr2:24480505(-) A-I      intronic chr2:24480506(-) A-I      intronic chr2:24557217(-) A-I      intronic chr2:24558361(-) A-I      intronic chr2:24558702(-) A-I      intronic chr2:24558921(-) A-I      intronic chr2:24558929(-) A-I      intronic chr2:24558946(-) A-I      intronic chr2:24558952(-) A-I      intronic chr2:24558962(-) A-I      intronic chr2:24571314(-) A-I      intronic chr2:24576220(-) A-I      intronic chr2:24576451(-) A-I      intronic chr2:24564582(-) A-I      intronic chr2:24564654(-) A-I      intronic chr2:24565235(-) A-I      intronic chr2:24565897(-) A-I      intronic chr2:24518304(-) A-I      intronic chr2:24565938(-) A-I      intronic chr2:24569806(-) A-I      intronic chr2:24569810(-) A-I      intronic chr2:24569869(-) A-I      intronic chr2:24558989(-) A-I      intronic chr2:24569947(-) A-I      intronic chr2:24444997(-) A-I      intronic chr2:24445634(-) A-I      intronic chr2:24445673(-) A-I      intronic chr2:24445749(-) A-I      intronic chr2:24449417(-) A-I      intronic chr2:24449443(-) A-I      intronic chr2:24450712(-) A-I      intronic chr2:24453525(-) A-I      intronic chr2:24453528(-) A-I      intronic chr2:24453529(-) A-I      intronic chr2:24478357(-) A-I      intronic chr2:24478428(-) A-I      intronic chr2:24480182(-) A-I      intronic chr2:24559002(-) A-I      intronic chr2:24559003(-) A-I      intronic chr2:24559107(-) A-I      intronic chr2:24559109(-) A-I      intronic chr2:24560492(-) A-I      intronic chr2:24560639(-) A-I      intronic chr2:24560649(-) A-I      intronic chr2:24562652(-) A-I      intronic chr2:24562724(-) A-I      intronic chr2:24562725(-) A-I      intronic chr2:24562761(-) A-I      intronic chr2:24562878(-) A-I      intronic chr2:24563250(-) A-I      intronic chr2:24564536(-) A-I      intronic chr2:24570004(-) A-I      intronic chr2:24570455(-) A-I      intronic chr2:24570720(-) A-I      intronic chr2:24570758(-) A-I      intronic chr2:24570761(-) A-I      intronic chr2:24571159(-) A-I      intronic chr2:24480577(-) A-I      intronic chr2:24487058(-) A-I      intronic chr2:24558999(-) A-I      intronic chr2:24518382(-) A-I      intronic chr2:24445002(-) A-I      intronic chr2:24560439(-) A-I      intronic chr2:24560384(-) A-I      intronic chr2:24558646(-) A-I      intronic chr2:24560425(-) A-I      intronic chr2:24480029(-) A-I      intronic chr2:24480563(-) A-I      intronic chr2:24560448(-) A-I      intronic chr2:24459543(-) A-I      intronic chr2:24562780(-) A-I      intronic chr2:24518191(-) A-I      intronic chr2:24570472(-) A-I      intronic chr2:24560357(-) A-I      intronic chr2:24570833(-) A-I      intronic chr2:24541117(-) A-I      intronic chr2:24558287(-) A-I      intronic chr2:24489729(-) A-I      intronic chr2:24528307(-) A-I      intronic chr2:24444940(-) A-I      intronic chr2:24445617(-) A-I      intronic chr2:24560465(-) A-I      intronic chr2:24480508(-) A-I      intronic chr2:24554989(-) A-I      intronic chr2:24506098(-) A-I      intronic chr2:24550347(-) A-I      intronic chr2:24480493(-) A-I      intronic chr2:24446522(-) A-I      intronic chr2:24580921(-) A-I      intronic chr2:24480034(-) A-I      intronic chr2:24548265(-) A-I      intronic chr2:24556919(-) A-I      intronic chr2:24565267(-) A-I      intronic chr2:24529703(-) A-I      intronic chr2:24517209(-) A-I      intronic chr2:24580947(-) A-I      intronic chr2:24560486(-) A-I      intronic chr2:24563298(-) A-I      intronic chr2:24558640(-) A-I      intronic chr2:24569928(-) A-I      intronic chr2:24569953(-) A-I      intronic chr2:24565132(-) A-I      intronic chr2:24570473(-) A-I      intronic chr2:24558854(-) A-I      intronic chr2:24539331(-) A-I      intronic chr2:24466587(-) A-I      intronic chr2:24560461(-) A-I      intronic chr2:24560352(-) A-I      intronic chr2:24554078(-) A-I      intronic chr2:24495552(-) A-I      intronic chr2:24482944(-) A-I      intronic chr2:24554145(-) A-I      intronic chr2:24480393(-) A-I      intronic chr2:24452427(-) A-I      intronic chr2:24480599(-) A-I      intronic chr2:24478369(-) A-I      intronic chr2:24570431(-) A-I      intronic chr2:24560358(-) A-I      intronic chr2:24550400(-) A-I      intronic chr2:24489744(-) A-I      intronic chr2:24560491(-) A-I      intronic chr2:24558294(-) A-I      intronic chr2:24570503(-) A-I      intronic chr2:24560424(-) A-I      intronic chr2:24564588(-) A-I      intronic chr2:24558710(-) A-I      intronic chr2:24529012(-) A-I      intronic chr2:24542989(-) A-I      intronic chr2:24557688(-) A-I      intronic chr2:24569872(-) A-I      intronic chr2:24528399(-) A-I      intronic chr2:24539423(-) A-I      intronic chr2:24540153(-) A-I      intronic chr2:24518340(-) A-I      intronic chr2:24480581(-) A-I      intronic chr2:24570731(-) A-I      intronic chr2:24560633(-) A-I      intronic chr2:24562730(-) A-I      intronic chr2:24570516(-) A-I      intronic chr2:24517212(-) A-I      intronic chr2:24518374(-) A-I      intronic chr2:24490451(-) A-I      intronic chr2:24558299(-) A-I      intronic chr2:24550362(-) A-I      intronic chr2:24489539(-) A-I      intronic chr2:24561626(-) A-I      intronic chr2:24445630(-) A-I      intronic chr2:24565169(-) A-I      intronic chr2:24550305(-) A-I      intronic chr2:24478325(-) A-I      intronic chr2:24466591(-) A-I      intronic chr2:24558385(-) A-I      intronic chr2:24459677(-) A-I      intronic chr2:24550440(-) A-I      intronic chr2:24539422(-) A-I      intronic chr2:24569952(-) A-I      intronic chr2:24478445(-) A-I      intronic chr2:24487902(-) A-I      intronic chr2:24487132(-) A-I      intronic chr2:24569898(-) A-I      intronic chr2:24528214(-) A-I      intronic chr2:24570863(-) A-I      intronic chr2:24558711(-) A-I      intronic chr2:24517183(-) A-I      intronic chr2:24562191(-) A-I      intronic chr2:24449909(-) A-I      intronic chr2:24558340(-) A-I      intronic chr2:24528260(-) A-I      intronic chr2:24518261(-) A-I      intronic chr2:24570845(-) A-I      intronic chr2:24570823(-) A-I      intronic chr2:24550306(-) A-I      intronic chr2:24483065(-) A-I      intronic chr2:24552361(-) A-I      intronic chr2:24580880(-) A-I      intronic chr2:24569830(-) A-I      intronic chr2:24459815(-) A-I      intronic chr2:24558366(-) A-I      intronic chr2:24576389(-) A-I      intronic chr2:24550196(-) A-I      intronic chr2:24468476(-) A-I      intronic chr2:24487939(-) A-I      intronic chr2:24490705(-) A-I      intronic chr2:24576263(-) A-I      intronic chr2:24558655(-) A-I      intronic chr2:24557267(-) A-I      intronic chr2:24495461(-) A-I      intronic chr2:24529138(-) A-I      intronic chr2:24528881(-) A-I      intronic chr2:24480113(-) A-I      intronic chr2:24449403(-) A-I      intronic chr2:24570690(-) A-I      intronic chr2:24478397(-) A-I      intronic chr2:24490646(-) A-I      intronic chr2:24562859(-) A-I      intronic chr2:24565248(-) A-I      intronic chr2:24554141(-) A-I      intronic chr2:24452222(-) A-I      intronic chr2:24480519(-) A-I      intronic chr2:24529076(-) A-I      intronic chr2:24480120(-) A-I      intronic chr2:24478365(-) A-I      intronic chr2:24444999(-) A-I      intronic chr2:24565129(-) A-I      intronic chr2:24570862(-) A-I      intronic chr2:24480094(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ITSN2	chr2:24560352(-) A-I intron -    22028664 chr2:24560357(-) A-I intron -    22028664 chr2:24560358(-) A-I intron -    22028664 chr2:24560384(-) A-I intron -    22028664 chr2:24560424(-) A-I intron -    22028664 chr2:24560425(-) A-I intron -    22028664 chr2:24560439(-) A-I intron -    22028664 chr2:24560448(-) A-I intron -    22028664 chr2:24560461(-) A-I intron -    22028664 chr2:24560465(-) A-I intron -    22028664 chr2:24560486(-) A-I intron -    22028664 chr2:24560491(-) A-I intron -    22028664 chr2:24565231(-) A-I intron -    21960545 chr2:24565235(-) A-I intron -    21960545 chr2:24565601(-) A-I intron -    21960545 chr2:24566360(-) A-I intron -    21960545 chr2:24494638(-) A-C exon CDS    21725310 chr2:24444932(-) A-G intron -    22484847 chr2:24444940(-) A-G intron -    22484847 chr2:24444999(-) A-G intron -    22484847 chr2:24445002(-) A-G intron -    22484847 chr2:24445009(-) A-G intron -    22484847 chr2:24449909(-) A-G intron -    22484847 chr2:24474018(-) T-G intron -    22484847 chr2:24478325(-) A-G intron -    22484847 chr2:24478365(-) A-G intron -    22484847 chr2:24478369(-) A-G intron -    22484847 chr2:24478445(-) A-G intron -    22484847 chr2:24478754(-) C-T intron -    22484847 chr2:24479941(-) A-G intron -    22484847 chr2:24479983(-) A-G intron -    22484847 chr2:24480029(-) A-G intron -    22484847 chr2:24480034(-) A-G intron -    22484847 chr2:24480094(-) A-G intron -    22484847 chr2:24480113(-) A-G intron -    22484847 chr2:24480442(-) A-G intron -    22484847 chr2:24480503(-) A-G intron -    22484847 chr2:24480581(-) A-G intron -    22484847 chr2:24480599(-) A-G intron -    22484847 chr2:24483771(-) A-T intron -    22484847 chr2:24483772(-) G-T intron -    22484847 chr2:24487069(-) A-G intron -    22484847 chr2:24487868(-) G-A intron -    22484847 chr2:24487887(-) A-G intron -    22484847 chr2:24487902(-) A-G intron -    22484847 chr2:24487939(-) A-G intron -    22484847 chr2:24489678(-) A-G intron -    22484847 chr2:24489729(-) A-G intron -    22484847 chr2:24489734(-) A-G intron -    22484847 chr2:24489744(-) A-G intron -    22484847 chr2:24490629(-) A-G intron -    22484847 chr2:24490646(-) A-G intron -    22484847 chr2:24514625(-) T-C intron -    22484847 chr2:24517038(-) A-G intron -    22484847 chr2:24517183(-) A-G intron -    22484847 chr2:24517209(-) A-G intron -    22484847 chr2:24517212(-) A-G intron -    22484847 chr2:24518261(-) A-G intron -    22484847 chr2:24528260(-) A-G intron -    22484847 chr2:24528307(-) A-G intron -    22484847 chr2:24529012(-) A-G intron -    22484847 chr2:24529138(-) A-G intron -    22484847 chr2:24539422(-) A-G intron -    22484847 chr2:24539423(-) A-G intron -    22484847 chr2:24540153(-) A-G intron -    22484847 chr2:24540201(-) A-G intron -    22484847 chr2:24540253(-) A-G intron -    22484847 chr2:24540254(-) G-T intron -    22484847 chr2:24541117(-) A-G intron -    22484847 chr2:24543089(-) T-G intron -    22484847 chr2:24543090(-) G-A intron -    22484847 chr2:24543092(-) A-T intron -    22484847 chr2:24556919(-) A-G intron -    22484847 chr2:24557267(-) A-G intron -    22484847 chr2:24557688(-) A-G intron -    22484847 chr2:24558294(-) A-G intron -    22484847 chr2:24558299(-) A-G intron -    22484847 chr2:24558326(-) A-G intron -    22484847 chr2:24558366(-) A-G intron -    22484847 chr2:24558601(-) A-G intron -    22484847 chr2:24558646(-) A-G intron -    22484847 chr2:24558655(-) A-G intron -    22484847 chr2:24558710(-) A-G intron -    22484847 chr2:24558711(-) A-G intron -    22484847 chr2:24560633(-) A-G intron -    22484847 chr2:24562730(-) A-G intron -    22484847 chr2:24562780(-) A-G intron -    22484847 chr2:24562859(-) A-G intron -    22484847 chr2:24562883(-) A-G intron -    22484847 chr2:24563298(-) A-G intron -    22484847 chr2:24563354(-) T-C intron -    22484847 chr2:24564588(-) A-G intron -    22484847 chr2:24565958(-) A-T intron -    22484847 chr2:24565959(-) G-T intron -    22484847 chr2:24569953(-) A-G intron -    22484847 chr2:24569961(-) A-G intron -    22484847 chr2:24570465(-) T-C intron -    22484847 chr2:24570472(-) A-G intron -    22484847 chr2:24570473(-) A-G intron -    22484847 chr2:24570503(-) A-G intron -    22484847 chr2:24570516(-) A-G intron -    22484847 chr2:24570731(-) A-G intron -    22484847 chr2:24570823(-) A-G intron -    22484847 chr2:24570829(-) A-G intron -    22484847 chr2:24570845(-) A-G intron -    22484847 chr2:24570850(-) A-G intron -    22484847 chr2:24570862(-) A-G intron -    22484847 chr2:24570863(-) A-G intron -    22484847 chr2:24570936(-) A-G intron -    22484847 chr2:24571155(-) A-G intron -    22484847 chr2:24571331(-) A-G intron -    22484847 chr2:24579771(-) A-T intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ITSN2	chr2:24426300-24426301(-) m6A 3'UTR//exon       - chr2:24426305-24426306(-) m6A 3'UTR//exon       - chr2:24426324-24426325(-) m6A 3'UTR//exon       - chr2:24426434-24426435(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085 chr2:24426467-24426468(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085 chr2:24426481-24426482(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27371828//22608085 chr2:24426505-24426506(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27371828//22608085 chr2:24426605-24426606(-) m6A 3'UTR//CDS//exon       - chr2:24426610-24426611(-) m6A 3'UTR//CDS//exon       - chr2:24427220-24427221(-) m6A 3'UTR//CDS//exon       27773535 chr2:24427230-24427231(-) m6A 3'UTR//CDS//exon       27773535 chr2:24428089-24428090(-) m6A 3'UTR//CDS//exon       27773535 chr2:24428151-24428152(-) m6A 3'UTR//CDS//exon       27773535 chr2:24428186-24428187(-) m6A exon//intron       - chr2:24428413-24428414(-) m6A exon//intron       27773535 chr2:24428497-24428498(-) m6A exon//intron       27773535 chr2:24428520-24428521(-) m6A exon//intron       27773535 chr2:24439078-24439079(-) m6A CDS       27773535 chr2:24462177-24462178(-) m6A 3'UTR//intron       27773535 chr2:24462216-24462217(-) m6A 3'UTR//intron       27773535 chr2:24462292-24462293(-) m6A 3'UTR//intron       27773535 chr2:24475228-24475229(-) m6A CDS       24981863 chr2:24475238-24475239(-) m6A CDS       24981863 chr2:24475278-24475279(-) m6A CDS       24981863 chr2:24493579-24493580(-) m6A CDS       27773535 chr2:24493631-24493632(-) m6A CDS       24981863//28052920//27773535//27371828//22608085 chr2:24494677-24494678(-) m6A CDS       24981863//28052920//27773535//27371828//22608085 chr2:24494721-24494722(-) m6A CDS       24981863//28052920//27773535//27371828//22608085 chr2:24494746-24494747(-) m6A CDS       24981863//28052920//27773535//27371828//22608085 chr2:24494753-24494754(-) m1A CDS       26863196 chr2:24494786-24494787(-) m6A CDS       24981863//28052920//27773535//27371828//22608085 chr2:24498601-24498602(-) m6A CDS       24981863//27773535//22608085 chr2:24498619-24498620(-) m6A CDS       24981863//27773535//22608085 chr2:24498676-24498677(-) m6A CDS       24981863//27773535//22608085 chr2:24498705-24498706(-) m6A CDS       27773535//22608085 chr2:24498715-24498716(-) m6A CDS       27773535 chr2:24516579-24516580(-) m6A CDS//exon       24981863//27773535 chr2:24518538-24518539(-) m6A CDS//exon       24981863//27773535//27371828 chr2:24518606-24518607(-) m6A CDS       24981863//27773535//27371828 chr2:24518615-24518616(-) m6A CDS       24981863//27773535//27371828 chr2:24518643-24518644(-) m6A CDS       24981863//27773535//27371828 chr2:24518664-24518665(-) m6A CDS       24981863//27773535//27371828 chr2:24521573-24521574(-) m6A CDS       24981863//27773535//27371828//22608085 chr2:24521596-24521597(-) m6A CDS       24981863//28052920//27773535//27371828//22608085 chr2:24521668-24521669(-) m6A CDS       24209618//24981863//28052920//27773535//27371828//22608085 chr2:24521674-24521675(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//22608085 chr2:24522793-24522794(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//22608085 chr2:24522819-24522820(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//22608085 chr2:24522867-24522868(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//22608085 chr2:24522882-24522883(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//22608085 chr2:24522900-24522901(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//22608085 chr2:24522997-24522998(-) m6A CDS       24981863//27773535//27371828//22608085 chr2:24523027-24523028(-) m6A CDS       24981863//27773535//27371828//22608085 chr2:24533402-24533403(-) m6A CDS       27773535 chr2:24533474-24533475(-) m6A CDS       27773535 chr2:24550953-24550954(-) m6A 5'UTR//CDS//exon       27773536 chr2:24550960-24550961(-) m6A 5'UTR//CDS//exon       27773536 chr2:24583531-24583532(-) m6A 5'UTR       27371828//27773536 chr2:24583555-24583556(-) m6A 5'UTR       27371828//27773536 chr2:24583575-24583576(-) m6A 5'UTR       27371828//27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ITSN2	Cytosol HCC cell line (HepG2)|HeLa-S3 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Membrane HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: ITSN2

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.