Detail Information

Basic Information:


  VIRBase ID:  

VHID00510456

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           LRP12:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p LRP12
miRBase
Accession/Entrez ID		 MIMAT0001581 29967
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - MIG13A//ST7

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR LRP12
chr8:105563830(-) A-I      intronic
chr8:105523357(-) A-I      intronic
chr8:105523332(-) A-I      intronic
chr8:105556112(-) A-I      intronic
chr8:105561854(-) A-I      intronic
chr8:105523423(-) A-I      intronic
chr8:105524462(-) A-I      intronic
chr8:105561911(-) A-I      intronic
chr8:105524397(-) A-I      intronic
chr8:105561089(-) A-I      intronic
chr8:105560934(-) A-I      intronic
chr8:105524463(-) A-I      intronic
chr8:105561859(-) A-I      intronic
chr8:105560935(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase LRP12
chr8:105501915-105501916(-) m6A 3'UTR//exon       27773535
chr8:105502047-105502048(-) m6A 3'UTR//exon       27773535
chr8:105502825-105502826(-) m6A 3'UTR//exon       24981863//27773535
chr8:105502964-105502965(-) m6A CDS//exon       24284625//24209618//24981863//28052920//27773535//27371828//22575960//22608085
chr8:105503059-105503060(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr8:105503071-105503072(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr8:105503101-105503102(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr8:105503126-105503127(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr8:105503206-105503207(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr8:105503222-105503223(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr8:105503335-105503336(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr8:105503513-105503514(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr8:105503569-105503570(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22608085
chr8:105503669-105503670(-) m6A CDS//exon       24209618//24981863//22608085
chr8:105509400-105509401(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr8:105509439-105509440(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr8:105509557-105509558(-) m6A 5'UTR//CDS       24284625//24209618//24981863//27773535//22608085
chr8:105509735-105509736(-) m6A 5'UTR//CDS       24284625//24209618//24981863//27773535//22608085
chr8:105509864-105509865(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr8:105509910-105509911(-) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr8:105509949-105509950(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr8:105510021-105510022(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr8:105510054-105510055(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr8:105510290-105510291(-) m6A CDS//exon       24209618
chr8:105518064-105518065(-) m6A exon//intron       27773535
chr8:105518085-105518086(-) m6A exon//intron       27773535
chr8:105518094-105518095(-) m6A exon//intron       27773535
chr8:105518999-105519000(-) m6A exon//intron       27773535
chr8:105519053-105519054(-) m6A exon//intron       27773535
chr8:105519067-105519068(-) m6A exon//intron       27773535
chr8:105519079-105519080(-) m6A exon//intron       27773535
chr8:105519099-105519100(-) m6A exon//intron       27773535
chr8:105521290-105521291(-) m6A CDS//exon       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate LRP12
Chromatin K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells|K562 cells     -
Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: LRP12

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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