Basic Information:

  VIRBase ID:  

VHID00510387

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          REPIN1:  NM_001362745     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	REPIN1
miRBase Accession/Entrez ID	MIMAT0001581	29803
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	AP4//RIP60//Zfp464//ZNF464

RNA Editing:

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	REPIN1	chr7:150071129(+) C-A intron -    21725310

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	REPIN1	chr7:150065381-150065382(+) m6A 5'UTR//exon       24981863 chr7:150065918-150065919(+) m6A 5'UTR//exon//intron       24981863 chr7:150065924-150065925(+) m6A 5'UTR//exon//intron       24981863 chr7:150066492-150066493(+) m6A exon//intron       - chr7:150066556-150066557(+) m6A exon//intron       - chr7:150066903-150066904(+) m6A 3'UTR//5'UTR//CDS//exon//intron       24284625 chr7:150066986-150066987(+) m6A exon//intron       24284625//25456834 chr7:150067268-150067269(+) m6A exon//intron       24284625//25456834 chr7:150067301-150067302(+) m6A exon//intron       25456834 chr7:150067313-150067314(+) m6A exon//intron       25456834 chr7:150068264-150068265(+) m6A 5'UTR//intron       24284625//25456834 chr7:150068326-150068327(+) m6A 3'UTR//5'UTR//CDS//exon       24284625//25456834 chr7:150068417-150068418(+) m6A 3'UTR//CDS//exon       24284625 chr7:150068667-150068668(+) m6A 3'UTR//CDS       24284625//24981863//22575960//22608085 chr7:150068898-150068899(+) m6A 3'UTR//CDS       24284625//25456834//24981863//26404942//22575960//22608085 chr7:150069241-150069242(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr7:150069379-150069380(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085 chr7:150069426-150069427(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085 chr7:150069561-150069562(+) m6A 3'UTR//CDS       24284625//25456834//24981863//22575960//22608085 chr7:150069742-150069743(+) m6A 3'UTR//CDS       24284625//22575960 chr7:150069980-150069981(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr7:150070000-150070001(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr7:150070019-150070020(+) m1A 3'UTR//CDS       26863196 chr7:150070132-150070133(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr7:150070221-150070222(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr7:150070363-150070364(+) m6A 3'UTR       24284625 chr7:150070421-150070422(+) Am 3'UTR       - chr7:150070492-150070493(+) m6A 3'UTR       24284625 chr7:150070510-150070511(+) m6A 3'UTR       24284625 chr7:150070604-150070605(+) m6A 3'UTR       24284625//22575960 chr7:150070614-150070615(+) m6A 3'UTR       24284625//22575960 chr7:150070768-150070769(+) m6A 3'UTR       24284625//25456834//24981863//22575960//22608085 chr7:150070820-150070821(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr7:150070897-150070898(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr7:150070933-150070934(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr7:150071065-150071066(+) m6A 3'UTR       24284625//24981863//27773535//22608085 chr7:150071070-150071071(+) m6A 3'UTR       24284625//24981863//27773535//22608085 chr7:150071075-150071076(+) m6A 3'UTR       24284625 chr7:150071100-150071101(+) m6A 3'UTR       24284625 chr7:150071127-150071128(+) m6A 3'UTR       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	REPIN1	Chromatin K562 cells     - Endoplasmic reticulum COS-7 cells     24019514 Exosome Blood     - Nucleolus K562 cells     - Nucleus COS-7 cells     24019514 Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: REPIN1

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.