Basic Information:

  VIRBase ID:  

VHID00510359

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7903

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          MYLIP:  NM_013262     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	MYLIP
miRBase Accession/Entrez ID	MIMAT0001581	29116
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	IDOL//MIR

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MYLIP	chr6:16139521(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MYLIP	chr6:16129419-16129420(+) m6A 5'UTR       24284625//24981863 chr6:16129626-16129627(+) m6A 5'UTR//CDS       24284625//24209618 chr6:16130828-16130829(+) m6A CDS//intron       24284625 chr6:16145210-16145211(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr6:16145251-16145252(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr6:16145309-16145310(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr6:16145324-16145325(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr6:16145375-16145376(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr6:16145410-16145411(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr6:16147001-16147002(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085 chr6:16147020-16147021(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr6:16147035-16147036(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr6:16147148-16147149(+) m6A 3'UTR       24284625//24981863//22608085 chr6:16147186-16147187(+) m6A 3'UTR       24284625//22608085 chr6:16147210-16147211(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	MYLIP	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: MYLIP

Evidence Support:

Strong-Evidence	RISC-IP
Prediction-Evidence	miRanda//RNAHybrid
Support Database	ViRBase//VmiReg

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.