Detail Information

Basic Information:


  VIRBase ID:  

VHID00510314

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           SLC43A3:      

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Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p SLC43A3
miRBase
Accession/Entrez ID		 MIMAT0001581 29015
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - EEG1//ENBT1//FOAP-13//PRO1659//SEEEG-1

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR SLC43A3
chr11:57191026(-) A-I      intronic
chr11:57185696(-) A-I      intronic
chr11:57191013(-) A-I      intronic
chr11:57185910(-) A-I      intronic
chr11:57185724(-) A-I      intronic
chr11:57181868(-) A-I      intronic
chr11:57185636(-) A-I      intronic
chr11:57190998(-) A-I      intronic
chr11:57191023(-) A-I      intronic
chr11:57185750(-) A-I      intronic
chr11:57185738(-) A-I      intronic
chr11:57190999(-) A-I      intronic
chr11:57187186(-) A-I      intronic
chr11:57185745(-) A-I      intronic
chr11:57185565(-) A-I      intronic
chr11:57191039(-) A-I      intronic
chr11:57186025(-) A-I      intronic
chr11:57185769(-) A-I      intronic
chr11:57191007(-) A-I      intronic
chr11:57185566(-) A-I      intronic
chr11:57187157(-) A-I      intronic
chr11:57175776(-) A-I      intronic
chr11:57187147(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SLC43A3
chr11:57174541-57174542(-) m6A 3'UTR//exon       25456834//24981863//28052920//27773535//27371828//22575960
chr11:57174774-57174775(-) m6A 3'UTR//exon       27371828//22575960
chr11:57174803-57174804(-) m6A 3'UTR//exon       27371828//22575960
chr11:57174993-57174994(-) m6A 3'UTR//exon       24209618//28052920//27773535//27371828//22575960
chr11:57175026-57175027(-) m6A 3'UTR//exon       24209618//25456834//24981863//28052920//27773535//27371828//22575960
chr11:57175042-57175043(-) m6A 3'UTR//exon       24209618//25456834//24981863//28052920//27773535//27371828//22575960
chr11:57175064-57175065(-) m6A 3'UTR//exon       24209618//25456834//24981863//28052920//27773535//27371828//22575960
chr11:57175129-57175130(-) m6A 3'UTR//exon       24209618//25456834//24981863//28052920//27773535//27371828//22575960
chr11:57175164-57175165(-) m6A 3'UTR//exon       24209618//24981863//28052920//27773535//27371828
chr11:57175184-57175185(-) m6A 3'UTR//exon       24209618//24981863//28052920//27773535//27371828
chr11:57175201-57175202(-) m6A 3'UTR//exon       24209618//24981863//28052920//27773535
chr11:57182090-57182091(-) m6A CDS       22575960
chr11:57182118-57182119(-) m6A CDS       22575960
chr11:57182128-57182129(-) m6A CDS       22575960
chr11:57182416-57182417(-) m6A CDS       22575960
chr11:57182550-57182551(-) m6A CDS       22575960
chr11:57182576-57182577(-) m6A CDS       22575960
chr11:57184086-57184087(-) m6A CDS//exon       22575960
chr11:57184102-57184103(-) m6A CDS//exon       22575960
chr11:57188529-57188530(-) m6A CDS//exon       27773535
chr11:57193038-57193039(-) m6A CDS//exon//intron       27773535//22575960
chr11:57193085-57193086(-) m6A CDS//exon//intron       27773535
chr11:57193142-57193143(-) m6A CDS//exon//intron       27773535//22575960
chr11:57193160-57193161(-) m6A CDS//intron       27773535//22575960
chr11:57193246-57193247(-) m6A 5'UTR//intron       22575960
chr11:57193501-57193502(-) m6A CDS//exon       22575960
chr11:57193681-57193682(-) m6A 5'UTR//exon       22575960
chr11:57193781-57193782(-) m6A 5'UTR//exon       27371828//22575960
chr11:57194219-57194220(-) m6A 5'UTR//intron       -
chr11:57194362-57194363(-) m6A 5'UTR//intron       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate SLC43A3
Chromatin K562 cells     -
Cytosol HeLa-S3 cells|K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: SLC43A3

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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