Basic Information:

  VIRBase ID:  

VHID00510277

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          TRIB2:  NR_027303     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	TRIB2
miRBase Accession/Entrez ID	MIMAT0001581	28951
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	C5FW//GS3955//TRB2

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TRIB2	chr2:12857468-12857469(+) m6A 5'UTR//exon//intron       25456834//22608085 chr2:12857500-12857501(+) m6A 5'UTR//exon//intron       25456834 chr2:12857920-12857921(+) m6A 5'UTR//intron       24209618//25456834 chr2:12857969-12857970(+) m6A 5'UTR//intron       24209618//25456834 chr2:12857998-12857999(+) m6A 5'UTR//intron       24209618//25456834//24981863//22608085 chr2:12858007-12858008(+) m6A 5'UTR//intron       24209618//25456834//24981863//22608085 chr2:12858130-12858131(+) m6A 5'UTR//intron       24209618//25456834//24981863//22608085 chr2:12858199-12858200(+) m6A 5'UTR//intron       24209618//25456834//24981863//22608085 chr2:12858223-12858224(+) m6A 5'UTR//intron       24209618//25456834//24981863//22608085 chr2:12858437-12858438(+) m6A CDS//intron       24981863//22608085 chr2:12858488-12858489(+) m6A CDS//intron       24209618//24981863//22608085 chr2:12858493-12858494(+) m6A CDS//intron       24209618//24981863//22608085 chr2:12858557-12858558(+) m6A CDS//intron       24209618//24981863//22608085 chr2:12858583-12858584(+) m6A CDS//intron       24209618//24981863//22608085 chr2:12858590-12858591(+) m6A CDS//intron       24209618//24981863//22608085 chr2:12858636-12858637(+) m6A CDS//intron       24209618 chr2:12858650-12858651(+) m6A CDS//intron       24209618 chr2:12863484-12863485(+) m6A 5'UTR//CDS       24209618 chr2:12863521-12863522(+) m6A 5'UTR//CDS       25456834//24981863 chr2:12863576-12863577(+) m6A CDS       24209618//25456834//24981863//22608085 chr2:12863638-12863639(+) m6A CDS       24209618//25456834//24981863//22608085 chr2:12880561-12880562(+) m6A CDS       24209618//25456834//24981863//22608085 chr2:12880661-12880662(+) m6A CDS       24209618//25456834//24981863//22608085 chr2:12880713-12880714(+) m6A CDS       24209618//25456834//24981863//22608085 chr2:12880798-12880799(+) m6A CDS       24209618//25456834//24981863//22575960//22608085 chr2:12880897-12880898(+) m6A CDS       24209618//25456834//24981863//22608085 chr2:12880903-12880904(+) m6A CDS       24209618//25456834//24981863//22608085 chr2:12880937-12880938(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr2:12880991-12880992(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr2:12881022-12881023(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr2:12881057-12881058(+) m6A 3'UTR       24209618//25456834//24981863//22608085 chr2:12881171-12881172(+) m6A 3'UTR       24209618//25456834//24981863//22608085 chr2:12881255-12881256(+) m6A 3'UTR       24209618

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	TRIB2	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HeLa-S3 cells|K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: TRIB2

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.