Basic Information:

  VIRBase ID:  

VHID00510269

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          SLCO4A1:  NM_016354     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	SLCO4A1
miRBase Accession/Entrez ID	MIMAT0001581	28231
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	OATP-E//OATP1//OATP4A1//OATPE//OATPRP1//POAT//SLC21A12

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SLCO4A1	chr20:61287828-61287829(+) m6A CDS       24284625//24209618//25456834//22575960 chr20:61287963-61287964(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr20:61288019-61288020(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr20:61288458-61288459(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr20:61292466-61292467(+) m6A CDS       24284625//22575960 chr20:61292496-61292497(+) m6A CDS       24284625//22575960 chr20:61292507-61292508(+) m6A CDS       24284625//22575960 chr20:61292517-61292518(+) m6A CDS       24284625//22575960 chr20:61296308-61296309(+) m6A CDS       24284625//22575960 chr20:61297788-61297789(+) m6A CDS//exon       24284625 chr20:61298831-61298832(+) m6A exon//intron       24284625 chr20:61298907-61298908(+) m6A exon//intron       24284625 chr20:61299119-61299120(+) m6A CDS//exon//intron       24284625 chr20:61299162-61299163(+) m6A CDS//exon//intron       24284625 chr20:61301362-61301363(+) m6A exon//intron       24284625 chr20:61301432-61301433(+) m6A exon//intron       24209618 chr20:61301478-61301479(+) m6A exon//intron       24209618 chr20:61303176-61303177(+) m6A 3'UTR//CDS//exon//intron       24284625//24981863//22575960 chr20:61303300-61303301(+) m6A 3'UTR//exon//intron       24284625//25456834//24981863//22575960//22608085 chr20:61303332-61303333(+) m6A 3'UTR//exon//intron       24284625//25456834//24981863//22575960//22608085 chr20:61303431-61303432(+) m6A 3'UTR//exon//intron       24284625 chr20:61303455-61303456(+) m6A 3'UTR//exon//intron       24284625 chr20:61303525-61303526(+) m6A 3'UTR//intron       24284625 chr20:61316941-61316942(+) m6A exon       25456834 chr20:61317010-61317011(+) m6A exon       25456834 chr20:61317048-61317049(+) m6A exon       25456834

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	SLCO4A1	Chromatin HeLa-S3 cells|K562 cells     - Cytosol HCC cell line (HepG2)     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: SLCO4A1

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.