Basic Information:

  VIRBase ID:  

VHID00510259

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          DESI1:  NM_015704     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	DESI1
miRBase Accession/Entrez ID	MIMAT0001581	27351
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	D15Wsu75e//DeSI-1//DESI2//DJ347H13.4//FAM152B//POST//PPPDE2

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	DESI1	chr22:42007202(-) A-I      intronic chr22:42007657(-) A-I      intronic chr22:42007665(-) A-I      intronic chr22:42007316(-) A-I      intronic chr22:42007210(-) A-I      intronic chr22:41995917(-) A-I      3'UTR chr22:41997846(-) A-I      intronic chr22:42010282(-) A-I      intronic chr22:42007330(-) A-I      intronic chr22:42007180(-) A-I      intronic chr22:42007410(-) A-I      intronic chr22:42010235(-) A-I      intronic chr22:42010266(-) A-I      intronic chr22:42010290(-) A-I      intronic chr22:42010313(-) A-I      intronic chr22:42015024(-) A-I      intronic chr22:42015017(-) A-I      intronic chr22:42014968(-) A-I      intronic chr22:42014245(-) A-I      intronic chr22:42014956(-) A-I      intronic chr22:42011058(-) A-I      intronic chr22:42010152(-) A-I      intronic chr22:42011068(-) A-I      intronic chr22:42011212(-) A-I      intronic chr22:42011368(-) A-I      intronic chr22:42008731(-) A-I      intronic chr22:42002172(-) A-I      intronic chr22:42008430(-) A-I      intronic chr22:42012021(-) A-I      intronic chr22:42012044(-) A-I      intronic chr22:42014132(-) A-I      intronic chr22:42014212(-) A-I      intronic chr22:42014904(-) A-I      intronic chr22:42014305(-) A-I      intronic chr22:42014291(-) A-I      intronic chr22:42008397(-) A-I      intronic chr22:42000523(-) A-I      intronic chr22:42000508(-) A-I      intronic chr22:42011060(-) A-I      intronic chr22:42000469(-) A-I      intronic chr22:42000421(-) A-I      intronic chr22:42008268(-) A-I      intronic chr22:42002578(-) A-I      intronic chr22:42002659(-) A-I      intronic chr22:42002666(-) A-I      intronic chr22:42005125(-) A-I      intronic chr22:42005577(-) A-I      intronic chr22:42005719(-) A-I      intronic chr22:42005787(-) A-I      intronic chr22:42005915(-) A-I      intronic chr22:42005972(-) A-I      intronic chr22:42005997(-) A-I      intronic chr22:42006021(-) A-I      intronic chr22:42006022(-) A-I      intronic chr22:42008256(-) A-I      intronic chr22:42006038(-) A-I      intronic chr22:42006045(-) A-I      intronic chr22:42006203(-) A-I      intronic chr22:42006283(-) A-I      intronic chr22:42006296(-) A-I      intronic chr22:42006300(-) A-I      intronic chr22:42006326(-) A-I      intronic chr22:42006380(-) A-I      intronic chr22:42007816(-) A-I      intronic chr22:42006714(-) A-I      intronic chr22:42006729(-) A-I      intronic chr22:42006742(-) A-I      intronic chr22:42006790(-) A-I      intronic chr22:42006794(-) A-I      intronic chr22:42006825(-) A-I      intronic chr22:42007314(-) A-I      intronic chr22:42006037(-) A-I      intronic chr22:42007815(-) A-I      intronic chr22:42007721(-) A-I      intronic chr22:42007708(-) A-I      intronic chr22:42007694(-) A-I      intronic chr22:42007379(-) A-I      intronic chr22:42007364(-) A-I      intronic chr22:41997905(-) A-I      intronic chr22:41997864(-) A-I      intronic chr22:41997833(-) A-I      intronic chr22:42010220(-) A-I      intronic chr22:42014267(-) A-I      intronic chr22:41997814(-) A-I      intronic chr22:41997803(-) A-I      intronic chr22:42010208(-) A-I      intronic chr22:42010188(-) A-I      intronic chr22:42010178(-) A-I      intronic chr22:42007355(-) A-I      intronic chr22:41995670(-) A-I      3'UTR chr22:41996124(-) A-I      3'UTR chr22:41996034(-) A-I      3'UTR chr22:41995649(-) A-I      3'UTR chr22:41995766(-) A-I      3'UTR chr22:41996040(-) A-I      3'UTR chr22:41995740(-) A-I      3'UTR chr22:41996035(-) A-I      3'UTR chr22:41995767(-) A-I      3'UTR chr22:41996195(-) A-I      3'UTR chr22:41995790(-) A-I      3'UTR chr22:41995639(-) A-I      3'UTR chr22:41995645(-) A-I      3'UTR chr22:41995616(-) A-I      3'UTR chr22:41996020(-) A-I      3'UTR chr22:41996192(-) A-I      3'UTR chr22:41996059(-) A-I      3'UTR chr22:41995805(-) A-I      3'UTR chr22:41995782(-) A-I      3'UTR chr22:41995601(-) A-I      3'UTR chr22:41995685(-) A-I      3'UTR chr22:41995669(-) A-I      3'UTR chr22:41996015(-) A-I      3'UTR chr22:41995731(-) A-I      3'UTR chr22:41995593(-) A-I      3'UTR chr22:42006002(-) A-I      intronic chr22:42005672(-) A-I      intronic chr22:42010544(-) A-I      intronic chr22:42005936(-) A-I      intronic chr22:42014810(-) A-I      intronic chr22:42005173(-) A-I      intronic chr22:42010563(-) A-I      intronic chr22:42010792(-) A-I      intronic chr22:42005142(-) A-I      intronic chr22:42006141(-) A-I      intronic chr22:42006384(-) A-I      intronic chr22:42007664(-) A-I      intronic chr22:42008463(-) A-I      intronic chr22:42007239(-) A-I      intronic chr22:42006261(-) A-I      intronic chr22:42011338(-) A-I      intronic chr22:42002638(-) A-I      intronic chr22:42007191(-) A-I      intronic chr22:42007735(-) A-I      intronic chr22:41997987(-) A-I      intronic chr22:42007881(-) A-I      intronic chr22:41997855(-) A-I      intronic chr22:42007325(-) A-I      intronic chr22:42012200(-) A-I      intronic chr22:42015005(-) A-I      intronic chr22:42005580(-) A-I      intronic chr22:42005048(-) A-I      intronic chr22:42007262(-) A-I      intronic chr22:42000378(-) A-I      intronic chr22:42005716(-) A-I      intronic chr22:42008714(-) A-I      intronic chr22:41997910(-) A-I      intronic chr22:42007176(-) A-I      intronic chr22:42005848(-) A-I      intronic chr22:42012165(-) A-I      intronic chr22:42007301(-) A-I      intronic chr22:42000417(-) A-I      intronic chr22:42002596(-) A-I      intronic chr22:42005084(-) A-I      intronic chr22:41997882(-) A-I      intronic chr22:42012203(-) A-I      intronic chr22:42010726(-) A-I      intronic chr22:42005183(-) A-I      intronic chr22:41995586(-) A-I      3'UTR chr22:41996161(-) A-I      3'UTR chr22:41995732(-) A-I      3'UTR chr22:41996164(-) A-I      3'UTR chr22:41996071(-) A-I      3'UTR chr22:41995631(-) A-I      3'UTR chr22:41995672(-) A-I      3'UTR chr22:41995624(-) A-I      3'UTR chr22:41996157(-) A-I      3'UTR chr22:41995636(-) A-I      3'UTR chr22:41995940(-) A-I      3'UTR chr22:41995844(-) A-I      3'UTR chr22:41996026(-) A-I      3'UTR chr22:41995836(-) A-I      3'UTR chr22:41995696(-) A-I      3'UTR chr22:41995692(-) A-I      3'UTR chr22:41995742(-) A-I      3'UTR chr22:41995926(-) A-I      3'UTR chr22:41995597(-) A-I      3'UTR chr22:41996181(-) A-I      3'UTR chr22:41996175(-) A-I      3'UTR chr22:41996145(-) A-I      3'UTR chr22:41996121(-) A-I      3'UTR chr22:41996017(-) A-I      3'UTR chr22:41995939(-) A-I      3'UTR chr22:41995957(-) A-I      3'UTR chr22:41995835(-) A-I      3'UTR chr22:41995679(-) A-I      3'UTR chr22:41995733(-) A-I      3'UTR chr22:41996100(-) A-I      3'UTR chr22:41995675(-) A-I      3'UTR chr22:41995728(-) A-I      3'UTR chr22:41995720(-) A-I      3'UTR chr22:41996083(-) A-I      3'UTR chr22:41996061(-) A-I      3'UTR chr22:41995599(-) A-I      3'UTR chr22:41995621(-) A-I      3'UTR chr22:41995745(-) A-I      3'UTR chr22:41995781(-) A-I      3'UTR chr22:42006200(-) A-I      intronic chr22:42005008(-) A-I      intronic chr22:42002613(-) A-I      intronic chr22:42005192(-) A-I      intronic chr22:42012083(-) A-I      intronic chr22:42005141(-) A-I      intronic chr22:42007145(-) A-I      intronic chr22:42002533(-) A-I      intronic chr22:42005128(-) A-I      intronic chr22:41997889(-) A-I      intronic chr22:42006186(-) A-I      intronic chr22:42007274(-) A-I      intronic chr22:42005630(-) A-I      intronic chr22:42011244(-) A-I      intronic chr22:42007868(-) A-I      intronic chr22:42010753(-) A-I      intronic chr22:42000437(-) A-I      intronic chr22:42005083(-) A-I      intronic chr22:42002610(-) A-I      intronic chr22:42002691(-) A-I      intronic chr22:42010113(-) A-I      intronic chr22:42005725(-) A-I      intronic chr22:42005726(-) A-I      intronic chr22:42005629(-) A-I      intronic chr22:42000426(-) A-I      intronic chr22:42005715(-) A-I      intronic chr22:42005021(-) A-I      intronic chr22:42014201(-) A-I      intronic chr22:42002284(-) A-I      intronic chr22:42011422(-) A-I      intronic chr22:42006320(-) A-I      intronic chr22:42002606(-) A-I      intronic chr22:42014812(-) A-I      intronic chr22:42005606(-) A-I      intronic chr22:42010561(-) A-I      intronic chr22:42007725(-) A-I      intronic chr22:42010793(-) A-I      intronic chr22:42002265(-) A-I      intronic chr22:42010137(-) A-I      intronic chr22:42008672(-) A-I      intronic chr22:42002776(-) A-I      intronic chr22:42010839(-) A-I      intronic chr22:42005847(-) A-I      intronic chr22:42014899(-) A-I      intronic chr22:42007699(-) A-I      intronic chr22:42007867(-) A-I      intronic chr22:42005662(-) A-I      intronic chr22:42007319(-) A-I      intronic chr22:42006307(-) A-I      intronic chr22:42006350(-) A-I      intronic chr22:42005218(-) A-I      intronic chr22:42012099(-) A-I      intronic chr22:42014879(-) A-I      intronic chr22:42005962(-) A-I      intronic chr22:42005013(-) A-I      intronic chr22:42011177(-) A-I      intronic chr22:42012147(-) A-I      intronic chr22:42005835(-) A-I      intronic chr22:42005219(-) A-I      intronic chr22:42002291(-) A-I      intronic chr22:42012234(-) A-I      intronic chr22:42002274(-) A-I      intronic chr22:42000346(-) A-I      intronic chr22:42007249(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	DESI1	chr22:42000426(-) A-I intron -    22327324 chr22:42008714(-) A-I intron -    22327324 chr22:42008720(-) A-I intron -    22327324 chr22:41995675(-) A-I exon 3'UTR    22327324 chr22:41995742(-) A-I exon 3'UTR    22327324 chr22:41996011(-) A-I exon 3'UTR    22327324 chr22:41996017(-) A-I exon 3'UTR    22327324 chr22:41996026(-) A-I exon 3'UTR    22327324 chr22:41996071(-) A-I exon 3'UTR    22327324 chr22:42002879(-) A-C intron -    22484847 chr22:42009185(-) A-G intron -    22484847 chr22:41995597(-) A-G exon 3'UTR    22484847 chr22:41995599(-) A-G exon 3'UTR    22484847 chr22:41995624(-) A-G exon 3'UTR    22484847 chr22:41995631(-) A-G exon 3'UTR    22484847 chr22:41995636(-) A-G exon 3'UTR    22484847 chr22:41995660(-) A-G exon 3'UTR    22484847 chr22:41995672(-) A-G exon 3'UTR    22484847 chr22:41995675(-) A-G exon 3'UTR    22484847 chr22:41995679(-) A-G exon 3'UTR    22484847 chr22:41995692(-) A-G exon 3'UTR    22484847 chr22:41995835(-) A-G exon 3'UTR    22484847 chr22:41995926(-) A-G exon 3'UTR    22484847 chr22:41995957(-) A-G exon 3'UTR    22484847 chr22:41996061(-) A-G exon 3'UTR    22484847 chr22:41996071(-) A-G exon 3'UTR    22484847 chr22:41996101(-) A-G exon 3'UTR    22484847 chr22:41996121(-) A-G exon 3'UTR    22484847 chr22:41996157(-) A-G exon 3'UTR    22484847 chr22:41996161(-) A-G exon 3'UTR    22484847 chr22:41996164(-) A-G exon 3'UTR    22484847 chr22:41997889(-) A-G intron -    22484847 chr22:42000346(-) A-G intron -    22484847 chr22:42000378(-) A-G intron -    22484847 chr22:42000388(-) A-G intron -    22484847 chr22:42000426(-) A-G intron -    22484847 chr22:42000427(-) A-G intron -    22484847 chr22:42000437(-) A-G intron -    22484847 chr22:42002284(-) A-G intron -    22484847 chr22:42002596(-) A-G intron -    22484847 chr22:42002613(-) A-G intron -    22484847 chr22:42005008(-) A-G intron -    22484847 chr22:42005013(-) A-G intron -    22484847 chr22:42005031(-) A-G intron -    22484847 chr22:42005629(-) A-G intron -    22484847 chr22:42005725(-) A-G intron -    22484847 chr22:42005762(-) A-G intron -    22484847 chr22:42005847(-) A-G intron -    22484847 chr22:42006384(-) A-G intron -    22484847 chr22:42007699(-) A-G intron -    22484847 chr22:42007735(-) A-G intron -    22484847 chr22:42008672(-) A-G intron -    22484847 chr22:42008714(-) A-G intron -    22484847 chr22:42008720(-) A-G intron -    22484847 chr22:42010221(-) A-G intron -    22484847 chr22:42010544(-) A-G intron -    22484847 chr22:42010574(-) A-G intron -    22484847 chr22:42010577(-) A-G intron -    22484847 chr22:42010788(-) A-G intron -    22484847 chr22:42010792(-) A-G intron -    22484847 chr22:42012234(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	DESI1	chr22:41994381-41994382(-) m6A 3'UTR       - chr22:41994536-41994537(-) m6A 3'UTR       27773535 chr22:41994883-41994884(-) m6A 3'UTR       24284625//22608085 chr22:41994893-41994894(-) m6A 3'UTR       24284625//22608085 chr22:41994940-41994941(-) m6A 3'UTR       24284625//24981863//22608085 chr22:41994982-41994983(-) m6A 3'UTR       24284625//24981863//27371828//22608085 chr22:41995208-41995209(-) m6A 3'UTR       24284625//24981863//22608085 chr22:41995287-41995288(-) m6A 3'UTR       24284625//24981863//22608085 chr22:41995330-41995331(-) m6A 3'UTR       - chr22:41996415-41996416(-) m6A 3'UTR       24284625//24981863 chr22:41996481-41996482(-) m6A 3'UTR       24284625//24981863//27773535//22608085 chr22:41996592-41996593(-) m6A 3'UTR       24284625//25456834//24981863//28052920//26404942//27773535//22575960//22608085 chr22:41996626-41996627(-) m6A 3'UTR       24284625//25456834//24981863//28052920//26404942//27773535//22575960//22608085 chr22:41996650-41996651(-) m6A 3'UTR       24284625//25456834//24981863//26404942//27773535//22575960//22608085 chr22:41996688-41996689(-) m6A 3'UTR       24284625//25456834//24981863//27773535//22575960//22608085 chr22:41996706-41996707(-) m6A 3'UTR       24284625//25456834//24981863//27773535//22575960//22608085 chr22:41996743-41996744(-) m6A 3'UTR       24284625//25456834//24981863//27773535//22575960//22608085 chr22:41996757-41996758(-) m6A 3'UTR       24284625//25456834//24981863//27773535//22575960//22608085 chr22:41996797-41996798(-) m6A 3'UTR       24284625//25456834//24981863//27773535//22575960//22608085 chr22:41996921-41996922(-) m6A 3'UTR//exon       24284625//24981863//27773535//22608085 chr22:41996926-41996927(-) m6A 3'UTR//exon       24284625//24981863//27773535//22608085 chr22:41996942-41996943(-) m6A 3'UTR//exon       24284625//24981863//27773535//22608085 chr22:41996961-41996962(-) m6A 3'UTR//exon       24284625//24981863//27773535//22608085 chr22:41997046-41997047(-) m6A 3'UTR//exon       24284625//24981863//26404942//27773535//22608085 chr22:41997051-41997052(-) m6A 3'UTR//exon       24284625//24981863//26404942//27773535//22608085 chr22:41997085-41997086(-) m6A 3'UTR//exon       24284625//25456834//24981863//27773535 chr22:41997095-41997096(-) m6A 3'UTR//exon       24284625//25456834//24981863//27773535 chr22:41997118-41997119(-) m6A CDS//exon       24284625//25456834//24981863//27773535 chr22:41997161-41997162(-) m6A CDS//exon       24284625//25456834//24981863//27773535 chr22:41997184-41997185(-) m6A CDS//exon       24284625//25456834//24981863 chr22:41998443-41998444(-) m6A exon//intron       24981863//27773535//22608085 chr22:41998448-41998449(-) m6A exon//intron       24981863//27773535//22608085 chr22:41998554-41998555(-) m6A exon//intron       24284625//24981863//27773535//22608085 chr22:41998593-41998594(-) m6A exon//intron       24284625//24981863//27773535//22608085 chr22:41998670-41998671(-) m6A exon//intron       24284625//24981863//27773535//22608085 chr22:41998756-41998757(-) m6A exon//intron       27773535 chr22:41999026-41999027(-) m6A exon//intron       27773535 chr22:41999032-41999033(-) m6A exon//intron       27773535 chr22:41999066-41999067(-) m6A exon//intron       27773535 chr22:41999286-41999287(-) m6A CDS//exon       27773535 chr22:41999360-41999361(-) m6A CDS//exon       27773535 chr22:42000122-42000123(-) Tm CDS//exon       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	DESI1	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: DESI1

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.