Detail Information

Basic Information:


  VIRBase ID:  

VHID00510254

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           TMEM97:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p TMEM97
miRBase
Accession/Entrez ID		 MIMAT0001581 27346
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - MAC30//sigma2R

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TMEM97
chr17:26654244(+) A-I      3'UTR
chr17:26654249(+) A-I      3'UTR
chr17:26650903(+) A-I      intronic
chr17:26650566(+) A-I      intronic
chr17:26650806(+) A-I      intronic
chr17:26654225(+) A-I      3'UTR
chr17:26654121(+) A-I      3'UTR
chr17:26654072(+) A-I      3'UTR
chr17:26650558(+) A-I      intronic
chr17:26654271(+) A-I      3'UTR
chr17:26654232(+) A-I      3'UTR
chr17:26654117(+) A-I      3'UTR
chr17:26654113(+) A-I      3'UTR
chr17:26654008(+) A-I      3'UTR
chr17:26650987(+) A-I      intronic
chr17:26650705(+) A-I      intronic
chr17:26650965(+) A-I      intronic
chr17:26654127(+) A-I      3'UTR
chr17:26654137(+) A-I      3'UTR
chr17:26654231(+) A-I      3'UTR
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED TMEM97
chr17:26654232(+) A-I intron -    21960545
chr17:26654113(+) A-G intron -    22484847
chr17:26654121(+) A-G intron -    22484847
chr17:26654137(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TMEM97
chr17:26652535-26652536(+) m6A 5'UTR//CDS//intron       24284625
chr17:26652568-26652569(+) m6A 5'UTR//CDS//intron       24284625
chr17:26652829-26652830(+) m6A 3'UTR//intron       24284625//24209618//22608085
chr17:26653579-26653580(+) m6A 5'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr17:26653680-26653681(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr17:26653686-26653687(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr17:26653693-26653694(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr17:26653824-26653825(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085
chr17:26653887-26653888(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085
chr17:26653899-26653900(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085
chr17:26653924-26653925(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085
chr17:26653963-26653964(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085
chr17:26653973-26653974(+) m6A 3'UTR       24284625//24209618//24981863//22608085
chr17:26654009-26654010(+) m6A 3'UTR       24284625//24209618//24981863//22608085
chr17:26654123-26654124(+) m6A 3'UTR       24209618//24981863
chr17:26654183-26654184(+) m6A 3'UTR       24209618
chr17:26654280-26654281(+) m6A 3'UTR       24284625//24209618//24981863//22608085
chr17:26654299-26654300(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085
chr17:26654328-26654329(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22575960//22608085
chr17:26654436-26654437(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr17:26654441-26654442(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr17:26654448-26654449(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr17:26654459-26654460(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr17:26654520-26654521(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085
chr17:26655132-26655133(+) m6A 3'UTR       27773535
chr17:26655361-26655362(+) m6A 3'UTR       27773535
chr17:26655428-26655429(+) m6A 3'UTR       27773535
chr17:26655508-26655509(+) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085
chr17:26655522-26655523(+) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate TMEM97
Chromatin K562 cells     -
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Insoluble cytoplasm HCC cell line (HepG2)     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: TMEM97

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

Starting a new search, please wait ...