Basic Information:

  VIRBase ID:  

VHID00510207

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          CSDC2:  NM_014460     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	CSDC2
miRBase Accession/Entrez ID	MIMAT0001581	27254
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	dJ347H13.2//PIPPIN

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CSDC2	chr22:41962510(+) A-I      intronic chr22:41962556(+) A-I      intronic chr22:41962547(+) A-I      intronic chr22:41962541(+) A-I      intronic chr22:41962567(+) A-I      intronic chr22:41962576(+) A-I      intronic chr22:41962511(+) A-I      intronic chr22:41969200(+) A-I      intronic chr22:41969179(+) A-I      intronic chr22:41967215(+) A-I      intronic chr22:41964391(+) A-I      intronic chr22:41964388(+) A-I      intronic chr22:41962748(+) A-I      intronic chr22:41962746(+) A-I      intronic chr22:41960908(+) A-I      intronic chr22:41960984(+) A-I      intronic chr22:41970326(+) A-I      intronic chr22:41964187(+) A-I      intronic chr22:41969093(+) A-I      intronic chr22:41964241(+) A-I      intronic chr22:41969094(+) A-I      intronic chr22:41959820(+) A-I      intronic chr22:41968954(+) A-I      intronic chr22:41969019(+) A-I      intronic chr22:41969287(+) A-I      intronic chr22:41970409(+) A-I      intronic chr22:41967123(+) A-I      intronic chr22:41962327(+) A-I      intronic chr22:41968983(+) A-I      intronic chr22:41970387(+) A-I      intronic chr22:41970396(+) A-I      intronic chr22:41968984(+) A-I      intronic chr22:41969239(+) A-I      intronic chr22:41966597(+) A-I      intronic chr22:41969386(+) A-I      intronic chr22:41961005(+) A-I      intronic chr22:41968992(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CSDC2	chr22:41957094-41957095(+) m6A 5'UTR       25456834 chr22:41957133-41957134(+) m6A 5'UTR       25456834 chr22:41957167-41957168(+) m6A 5'UTR       25456834 chr22:41971180-41971181(+) m6A 3'UTR//intron       25456834 chr22:41971189-41971190(+) m6A 3'UTR//intron       25456834 chr22:41971366-41971367(+) m6A 3'UTR//intron       25456834 chr22:41971435-41971436(+) m6A 3'UTR//intron       25456834 chr22:41971764-41971765(+) m6A 3'UTR//intron       24209618//25456834//24981863 chr22:41971808-41971809(+) m6A 3'UTR//intron       24209618//25456834//24981863 chr22:41971833-41971834(+) m6A 3'UTR//intron       24209618//25456834//24981863 chr22:41971857-41971858(+) m6A 3'UTR//intron       24209618//25456834//24981863 chr22:41972143-41972144(+) m6A 3'UTR//intron       25456834 chr22:41972154-41972155(+) m6A 3'UTR//intron       25456834 chr22:41972172-41972173(+) m6A 3'UTR//intron       25456834 chr22:41972248-41972249(+) m6A 3'UTR//intron       25456834 chr22:41972621-41972622(+) m6A 3'UTR//intron       24981863 chr22:41972651-41972652(+) m6A 3'UTR//intron       24981863 chr22:41973283-41973284(+) m6A CDS       24981863//27371828 chr22:41973386-41973387(+) m6A CDS       27371828//27773536 chr22:41973511-41973512(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	CSDC2	Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: CSDC2

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.