Basic Information:

  VIRBase ID:  

VHID00510155

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          FILIP1:  NR_110608     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	FILIP1
miRBase Accession/Entrez ID	MIMAT0001581	27145
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	FILIP

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	FILIP1	chr6:76102687(-) A-I      intronic chr6:76102686(-) A-I      intronic chr6:76102660(-) A-I      intronic chr6:76102672(-) A-I      intronic chr6:76102677(-) A-I      intronic chr6:76102680(-) A-I      intronic chr6:76102685(-) A-I      intronic chr6:76062710(-) A-I      intronic chr6:76062709(-) A-I      intronic chr6:76062708(-) A-I      intronic chr6:76062705(-) A-I      intronic chr6:76062684(-) A-I      intronic chr6:76062682(-) A-I      intronic chr6:76062668(-) A-I      intronic chr6:76062665(-) A-I      intronic chr6:76062662(-) A-I      intronic chr6:76062651(-) A-I      intronic chr6:76030090(-) A-I      intronic chr6:76030912(-) A-I      intronic chr6:76081862(-) A-I      intronic chr6:76117177(-) A-I      intronic chr6:76050675(-) A-I      intronic chr6:76050549(-) A-I      intronic chr6:76049601(-) A-I      intronic chr6:76050517(-) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	FILIP1	chr6:76003044-76003045(-) m6A 3'UTR       24981863 chr6:76003126-76003127(-) m6A 3'UTR       24981863 chr6:76005566-76005567(-) m6A 3'UTR       24981863 chr6:76005616-76005617(-) m6A 3'UTR       24981863 chr6:76005635-76005636(-) m6A CDS       24981863 chr6:76022306-76022307(-) m6A CDS//exon       24981863 chr6:76022356-76022357(-) m6A CDS//exon       24981863//27773535 chr6:76022418-76022419(-) m6A CDS//exon       25456834//24981863//27773535 chr6:76022444-76022445(-) m6A CDS//exon       25456834//24981863//27773535 chr6:76022545-76022546(-) m6A CDS//exon       24981863//27773535 chr6:76022576-76022577(-) m6A CDS//exon       24981863//27773535 chr6:76022655-76022656(-) m6A CDS//exon       27773535 chr6:76023340-76023341(-) m6A CDS//exon       24981863 chr6:76023391-76023392(-) m6A CDS//exon       24981863 chr6:76023426-76023427(-) m6A CDS//exon       24981863//27773535 chr6:76023432-76023433(-) m6A CDS//exon       24981863//27773535 chr6:76023542-76023543(-) m6A CDS//exon       24981863//27773535 chr6:76023555-76023556(-) m6A CDS//exon       24981863//27773535 chr6:76023581-76023582(-) m6A CDS//exon       24981863 chr6:76023633-76023634(-) m6A CDS//exon       24981863 chr6:76023654-76023655(-) m6A CDS//exon       24981863 chr6:76023750-76023751(-) m6A CDS//exon       24981863//27773535 chr6:76023879-76023880(-) m6A CDS//exon       24981863 chr6:76023888-76023889(-) m6A CDS//exon       24981863 chr6:76023909-76023910(-) m6A CDS//exon       24981863//27773535 chr6:76023939-76023940(-) m6A CDS//exon       24981863//27773535 chr6:76023963-76023964(-) m6A CDS//exon       24981863//27773535 chr6:76023987-76023988(-) m6A CDS//exon       24981863//27773535 chr6:76024153-76024154(-) m6A CDS//exon       24981863 chr6:76024165-76024166(-) m6A CDS//exon       24981863 chr6:76024245-76024246(-) m6A CDS//exon       24981863 chr6:76024281-76024282(-) m6A CDS//exon       24981863 chr6:76024302-76024303(-) m6A CDS//exon       24981863 chr6:76024349-76024350(-) m6A CDS//exon       24981863 chr6:76024429-76024430(-) m6A CDS//exon       24981863//27773535 chr6:76024473-76024474(-) m6A CDS//exon       27773535 chr6:76024505-76024506(-) m6A CDS//exon       27773535 chr6:76024587-76024588(-) m6A CDS//exon       24981863 chr6:76024635-76024636(-) m6A CDS//exon       24981863 chr6:76024642-76024643(-) m6A CDS//exon       24981863 chr6:76024672-76024673(-) m6A CDS//exon       24981863 chr6:76063316-76063317(-) m6A CDS       24981863 chr6:76124452-76124453(-) m6A CDS       24981863 chr6:76124483-76124484(-) m6A CDS       24981863 chr6:76124507-76124508(-) m6A CDS       24981863 chr6:76124528-76124529(-) m6A CDS       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	FILIP1	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: FILIP1

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.