Basic Information:

  VIRBase ID:  

VHID00510077

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          RNF11:  NM_014372     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	RNF11
miRBase Accession/Entrez ID	MIMAT0001581	26994
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	CGI-123//SID1669

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	RNF11	chr1:51717592(+) A-I      intronic chr1:51719097(+) A-I      intronic chr1:51717564(+) A-I      intronic chr1:51737145(+) A-I      3'UTR chr1:51719084(+) A-I      intronic chr1:51712543(+) A-I      intronic chr1:51712089(+) A-I      intronic chr1:51733506(+) A-I      intronic chr1:51717600(+) A-I      intronic chr1:51717599(+) A-I      intronic chr1:51712085(+) A-I      intronic chr1:51711325(+) A-I      intronic chr1:51719101(+) A-I      intronic chr1:51719120(+) A-I      intronic chr1:51733555(+) A-I      intronic chr1:51733574(+) A-I      intronic chr1:51733586(+) A-I      intronic chr1:51720397(+) A-I      intronic chr1:51735319(+) A-I      intronic chr1:51735048(+) A-I      intronic chr1:51733683(+) A-I      intronic chr1:51733520(+) A-I      intronic chr1:51733482(+) A-I      intronic chr1:51732754(+) A-I      intronic chr1:51731617(+) A-I      intronic chr1:51729892(+) A-I      intronic chr1:51729881(+) A-I      intronic chr1:51729866(+) A-I      intronic chr1:51729697(+) A-I      intronic chr1:51727666(+) A-I      intronic chr1:51721071(+) A-I      intronic chr1:51721049(+) A-I      intronic chr1:51720417(+) A-I      intronic chr1:51720409(+) A-I      intronic chr1:51720398(+) A-I      intronic chr1:51720396(+) A-I      intronic chr1:51720382(+) A-I      intronic chr1:51720260(+) A-I      intronic chr1:51719542(+) A-I      intronic chr1:51719091(+) A-I      intronic chr1:51718707(+) A-I      intronic chr1:51718624(+) A-I      intronic chr1:51718554(+) A-I      intronic chr1:51718197(+) A-I      intronic chr1:51718109(+) A-I      intronic chr1:51717671(+) A-I      intronic chr1:51717647(+) A-I      intronic chr1:51717644(+) A-I      intronic chr1:51717640(+) A-I      intronic chr1:51717631(+) A-I      intronic chr1:51717591(+) A-I      intronic chr1:51717589(+) A-I      intronic chr1:51718592(+) A-I      intronic chr1:51712090(+) A-I      intronic chr1:51712048(+) A-I      intronic chr1:51711839(+) A-I      intronic chr1:51711826(+) A-I      intronic chr1:51711806(+) A-I      intronic chr1:51711758(+) A-I      intronic chr1:51711754(+) A-I      intronic chr1:51711752(+) A-I      intronic chr1:51711383(+) A-I      intronic chr1:51711224(+) A-I      intronic chr1:51711086(+) A-I      intronic chr1:51709272(+) A-I      intronic chr1:51709250(+) A-I      intronic chr1:51705348(+) A-I      intronic chr1:51712988(+) A-I      intronic chr1:51717552(+) A-I      intronic chr1:51717565(+) A-I      intronic chr1:51712151(+) A-I      intronic chr1:51712148(+) A-I      intronic chr1:51712251(+) A-I      intronic chr1:51712267(+) A-I      intronic chr1:51712552(+) A-I      intronic chr1:51709240(+) A-I      intronic chr1:51727710(+) A-I      intronic chr1:51712965(+) A-I      intronic chr1:51706877(+) A-I      intronic chr1:51733421(+) A-I      intronic chr1:51710764(+) A-I      intronic chr1:51711253(+) A-I      intronic chr1:51709339(+) A-I      intronic chr1:51719528(+) A-I      intronic chr1:51711761(+) A-I      intronic chr1:51711308(+) A-I      intronic chr1:51719134(+) A-I      intronic chr1:51718981(+) A-I      intronic chr1:51711045(+) A-I      intronic chr1:51719596(+) A-I      intronic chr1:51729693(+) A-I      intronic chr1:51715003(+) A-I      intronic chr1:51729692(+) A-I      intronic chr1:51708349(+) A-I      intronic chr1:51732826(+) A-I      intronic chr1:51712100(+) A-I      intronic chr1:51727312(+) A-I      intronic chr1:51732791(+) A-I      intronic chr1:51721018(+) A-I      intronic chr1:51713193(+) A-I      intronic chr1:51729882(+) A-I      intronic chr1:51711887(+) A-I      intronic chr1:51721019(+) A-I      intronic chr1:51711322(+) A-I      intronic chr1:51711270(+) A-I      intronic chr1:51711780(+) A-I      intronic chr1:51712347(+) A-I      intronic chr1:51736171(+) A-I      intronic chr1:51711027(+) A-I      intronic chr1:51730945(+) A-I      intronic chr1:51713158(+) A-I      intronic chr1:51732761(+) A-I      intronic chr1:51712547(+) A-I      intronic chr1:51712982(+) A-I      intronic chr1:51712273(+) A-I      intronic chr1:51712575(+) A-I      intronic chr1:51727692(+) A-I      intronic chr1:51712570(+) A-I      intronic chr1:51729648(+) A-I      intronic chr1:51714058(+) A-I      intronic chr1:51721097(+) A-I      intronic chr1:51721061(+) A-I      intronic chr1:51711858(+) A-I      intronic chr1:51731604(+) A-I      intronic chr1:51718091(+) A-I      intronic chr1:51720261(+) A-I      intronic chr1:51733456(+) A-I      intronic chr1:51732758(+) A-I      intronic chr1:51710881(+) A-I      intronic chr1:51714981(+) A-I      intronic chr1:51711666(+) A-I      intronic chr1:51711986(+) A-I      intronic chr1:51713005(+) A-I      intronic chr1:51709313(+) A-I      intronic chr1:51728283(+) A-I      intronic chr1:51712014(+) A-I      intronic chr1:51717658(+) A-I      intronic chr1:51736134(+) A-I      intronic chr1:51711087(+) A-I      intronic chr1:51712116(+) A-I      intronic chr1:51717518(+) A-I      intronic chr1:51732772(+) A-I      intronic chr1:51733542(+) A-I      intronic chr1:51711682(+) A-I      intronic chr1:51718678(+) A-I      intronic chr1:51731593(+) A-I      intronic chr1:51719535(+) A-I      intronic chr1:51719052(+) A-I      intronic chr1:51712274(+) A-I      intronic chr1:51720370(+) A-I      intronic chr1:51710897(+) A-I      intronic chr1:51733583(+) A-I      intronic chr1:51712338(+) A-I      intronic chr1:51719158(+) A-I      intronic chr1:51711025(+) A-I      intronic chr1:51736165(+) A-I      intronic chr1:51730946(+) A-I      intronic chr1:51727761(+) A-I      intronic chr1:51732800(+) A-I      intronic chr1:51729907(+) A-I      intronic chr1:51717699(+) A-I      intronic chr1:51711384(+) A-I      intronic chr1:51732748(+) A-I      intronic chr1:51717590(+) A-I      intronic chr1:51717478(+) A-I      intronic chr1:51721020(+) A-I      intronic chr1:51732839(+) A-I      intronic chr1:51721098(+) A-I      intronic chr1:51728697(+) A-I      intronic chr1:51718628(+) A-I      intronic chr1:51718703(+) A-I      intronic chr1:51732784(+) A-I      intronic chr1:51718638(+) A-I      intronic chr1:51717617(+) A-I      intronic chr1:51732836(+) A-I      intronic chr1:51717345(+) A-I      intronic chr1:51727644(+) A-I      intronic chr1:51708056(+) A-I      intronic chr1:51729832(+) A-I      intronic chr1:51708382(+) A-I      intronic chr1:51719048(+) A-I      intronic chr1:51711676(+) A-I      intronic chr1:51706954(+) A-I      intronic chr1:51712957(+) A-I      intronic chr1:51718681(+) A-I      intronic chr1:51711683(+) A-I      intronic chr1:51712150(+) A-I      intronic chr1:51717704(+) A-I      intronic chr1:51711756(+) A-I      intronic chr1:51733532(+) A-I      intronic chr1:51714964(+) A-I      intronic chr1:51712126(+) A-I      intronic chr1:51713017(+) A-I      intronic chr1:51711263(+) A-I      intronic chr1:51712565(+) A-I      intronic chr1:51712908(+) A-I      intronic chr1:51712668(+) A-I      intronic chr1:51719110(+) A-I      intronic chr1:51735042(+) A-I      intronic chr1:51719074(+) A-I      intronic chr1:51720268(+) A-I      intronic chr1:51727501(+) A-I      intronic chr1:51735047(+) A-I      intronic chr1:51729818(+) A-I      intronic chr1:51735028(+) A-I      intronic chr1:51711699(+) A-I      intronic chr1:51732790(+) A-I      intronic chr1:51711790(+) A-I      intronic chr1:51711817(+) A-I      intronic chr1:51717586(+) A-I      intronic chr1:51712184(+) A-I      intronic chr1:51719013(+) A-I      intronic chr1:51720264(+) A-I      intronic chr1:51718625(+) A-I      intronic chr1:51729808(+) A-I      intronic chr1:51712144(+) A-I      intronic chr1:51718964(+) A-I      intronic chr1:51728263(+) A-I      intronic chr1:51719600(+) A-I      intronic chr1:51735023(+) A-I      intronic chr1:51733451(+) A-I      intronic chr1:51713027(+) A-I      intronic chr1:51712065(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	RNF11	chr1:51719596(+) A-I intron -    21960545 chr1:51704443(+) C-A intron -    22484847 chr1:51708349(+) A-G intron -    22484847 chr1:51710881(+) A-G intron -    22484847 chr1:51711025(+) A-G intron -    22484847 chr1:51711027(+) A-G intron -    22484847 chr1:51711045(+) A-G intron -    22484847 chr1:51711253(+) A-G intron -    22484847 chr1:51711263(+) A-G intron -    22484847 chr1:51711270(+) A-G intron -    22484847 chr1:51711308(+) A-G intron -    22484847 chr1:51711322(+) A-G intron -    22484847 chr1:51711384(+) A-G intron -    22484847 chr1:51711676(+) A-G intron -    22484847 chr1:51711682(+) A-G intron -    22484847 chr1:51711683(+) A-G intron -    22484847 chr1:51711756(+) A-G intron -    22484847 chr1:51711817(+) A-G intron -    22484847 chr1:51711887(+) A-G intron -    22484847 chr1:51711986(+) A-G intron -    22484847 chr1:51712100(+) A-G intron -    22484847 chr1:51712126(+) A-G intron -    22484847 chr1:51712273(+) A-G intron -    22484847 chr1:51712338(+) A-G intron -    22484847 chr1:51712347(+) A-G intron -    22484847 chr1:51713126(+) G-T intron -    22484847 chr1:51713158(+) A-G intron -    22484847 chr1:51713193(+) A-G intron -    22484847 chr1:51715003(+) A-G intron -    22484847 chr1:51717478(+) A-G intron -    22484847 chr1:51719528(+) A-G intron -    22484847 chr1:51719535(+) A-G intron -    22484847 chr1:51720261(+) A-G intron -    22484847 chr1:51720264(+) A-G intron -    22484847 chr1:51720268(+) A-G intron -    22484847 chr1:51727501(+) A-G intron -    22484847 chr1:51727761(+) A-G intron -    22484847 chr1:51730887(+) A-G intron -    22484847 chr1:51730945(+) A-G intron -    22484847 chr1:51730946(+) A-G intron -    22484847 chr1:51731593(+) A-G intron -    22484847 chr1:51732658(+) A-G intron -    22484847 chr1:51732748(+) A-G intron -    22484847 chr1:51732772(+) A-G intron -    22484847 chr1:51732784(+) A-G intron -    22484847 chr1:51732791(+) A-G intron -    22484847 chr1:51732826(+) A-G intron -    22484847 chr1:51732836(+) A-G intron -    22484847 chr1:51733542(+) A-G intron -    22484847 chr1:51733583(+) A-G intron -    22484847 chr1:51735023(+) A-G intron -    22484847 chr1:51735047(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RNF11	chr1:51702358-51702359(+) m6A 5'UTR//exon       24284625//24981863 chr1:51702435-51702436(+) m6A CDS//exon       24284625 chr1:51735629-51735630(+) m6A CDS//exon//intron       24284625 chr1:51735669-51735670(+) m6A CDS//exon//intron       24284625//24209618//24981863//22608085 chr1:51735701-51735702(+) m6A CDS//exon//intron       24284625//24209618//24981863//22575960//22608085 chr1:51736842-51736843(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr1:51736857-51736858(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr1:51736899-51736900(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr1:51736985-51736986(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr1:51737023-51737024(+) m6A 3'UTR//exon       24284625//24209618//24981863//22575960//22608085 chr1:51738507-51738508(+) m6A 3'UTR       27773535 chr1:51738643-51738644(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	RNF11	Chromatin K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     - Ribosome-free cytosol Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: RNF11

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.