Basic Information:

  VIRBase ID:  

VHID00509994

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          PPP1R14B:  NM_138689     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	PPP1R14B
miRBase Accession/Entrez ID	MIMAT0001581	26472
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	PHI-1//PLCB3N//PNG//SOM172

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PPP1R14B	chr11:64012144-64012145(-) m6A 3'UTR       27773535//27371828 chr11:64012188-64012189(-) m6A 3'UTR       27773535//27371828//22575960 chr11:64012271-64012272(-) m6A CDS       27773535//27371828//27773536//22575960 chr11:64012410-64012411(-) m6A CDS       27773535//27371828//27773536//22575960 chr11:64012712-64012713(-) m6A 5'UTR//CDS       27773535//27371828//27773536//22575960 chr11:64012741-64012742(-) m6A 5'UTR//CDS       27773535//27371828//27773536//22575960 chr11:64013538-64013539(-) m6A 5'UTR//intron       24981863 chr11:64014070-64014071(-) m6A CDS       24284625//24209618//27773536//22575960 chr11:64014137-64014138(-) m6A CDS       24284625//24209618//27773536 chr11:64014363-64014364(-) m6A 5'UTR       24209618//25456834//24981863 chr11:64014411-64014412(-) m6A 5'UTR       25456834

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	PPP1R14B	Exosome Blood     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: PPP1R14B

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.