Basic Information:

  VIRBase ID:  

VHID00509839

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          PLEKHG3:  NM_001308147     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	PLEKHG3
miRBase Accession/Entrez ID	MIMAT0001581	26030
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	ARHGEF43//KIAA0599

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PLEKHG3	chr14:65202181(+) A-I      intronic chr14:65202217(+) A-I      intronic chr14:65201580(+) A-I      intronic chr14:65202224(+) A-I      intronic chr14:65202207(+) A-I      intronic chr14:65200045(+) A-I      intronic chr14:65200032(+) A-I      intronic chr14:65202052(+) A-I      intronic chr14:65202262(+) A-I      intronic chr14:65201630(+) A-I      intronic chr14:65202129(+) A-I      intronic chr14:65202165(+) A-I      intronic chr14:65202189(+) A-I      intronic chr14:65202201(+) A-I      intronic chr14:65201718(+) A-I      intronic chr14:65202148(+) A-I      intronic chr14:65202237(+) A-I      intronic chr14:65202248(+) A-I      intronic chr14:65202134(+) A-I      intronic chr14:65202128(+) A-I      intronic chr14:65202083(+) A-I      intronic chr14:65202260(+) A-I      intronic chr14:65201584(+) A-I      intronic chr14:65202256(+) A-I      intronic chr14:65190319(+) A-I      intronic chr14:65178392(+) A-I      intronic chr14:65202185(+) A-I      intronic chr14:65202274(+) A-I      intronic chr14:65202205(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PLEKHG3	chr14:65197548-65197549(+) m6A CDS//exon       24284625 chr14:65197575-65197576(+) m6A CDS//exon       24284625 chr14:65198183-65198184(+) m6A CDS//exon       24284625 chr14:65198465-65198466(+) m6A CDS//exon       24284625 chr14:65198818-65198819(+) m6A CDS//exon       24284625 chr14:65198837-65198838(+) m6A CDS//exon       24284625 chr14:65198842-65198843(+) m6A CDS//exon       24284625 chr14:65198873-65198874(+) m6A CDS//exon       24284625 chr14:65202400-65202401(+) Am intron       - chr14:65203580-65203581(+) m6A CDS//exon       24209618 chr14:65204052-65204053(+) m6A exon//intron       25456834 chr14:65204751-65204752(+) m6A 5'UTR//intron       24284625//25456834//24981863 chr14:65207763-65207764(+) m6A CDS//exon       24284625//24209618 chr14:65207835-65207836(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr14:65207861-65207862(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr14:65207898-65207899(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr14:65207919-65207920(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr14:65207946-65207947(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr14:65208033-65208034(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr14:65208102-65208103(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr14:65208210-65208211(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr14:65208243-65208244(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr14:65208270-65208271(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr14:65208372-65208373(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22608085 chr14:65208387-65208388(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22608085 chr14:65208389-65208390(+) Am CDS//exon       - chr14:65208418-65208419(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22608085 chr14:65208478-65208479(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr14:65208489-65208490(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr14:65208525-65208526(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr14:65208559-65208560(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr14:65208607-65208608(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr14:65208630-65208631(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr14:65208978-65208979(+) m6A CDS//exon//intron       24284625//25456834//24981863//26404942//22608085 chr14:65209005-65209006(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//22608085 chr14:65209836-65209837(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr14:65209890-65209891(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr14:65210014-65210015(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr14:65210145-65210146(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr14:65210164-65210165(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr14:65210179-65210180(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr14:65210210-65210211(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr14:65210258-65210259(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr14:65210296-65210297(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr14:65210344-65210345(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr14:65210353-65210354(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr14:65210380-65210381(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr14:65210407-65210408(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr14:65210468-65210469(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//22608085 chr14:65210615-65210616(+) m6A 3'UTR//exon//intron       24284625 chr14:65210790-65210791(+) m6A 3'UTR//exon       24284625 chr14:65213447-65213448(+) m6A 3'UTR       24284625 chr14:65213475-65213476(+) m6A 3'UTR       24284625 chr14:65213510-65213511(+) m6A 3'UTR       24284625 chr14:65216178-65216179(+) m6A 3'UTR       - chr14:65216276-65216277(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	PLEKHG3	Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleus Colon cancer cells     24393600 Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: PLEKHG3

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.