Basic Information:

  VIRBase ID:  

VHID00509801

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          SH2B1:  NM_001145812     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	SH2B1
miRBase Accession/Entrez ID	MIMAT0001581	25970
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	PSM//SH2B

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SH2B1	chr16:28882218(+) A-I      intronic chr16:28882712(+) A-I      intronic chr16:28882699(+) A-I      intronic chr16:28882567(+) A-I      intronic chr16:28882735(+) A-I      intronic chr16:28882766(+) A-I      intronic chr16:28882561(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SH2B1	chr16:28874624-28874625(+) m6A 5'UTR//intron       25456834//27773536//22608085 chr16:28874632-28874633(+) m6A 5'UTR//intron       25456834//27773536//22608085 chr16:28874657-28874658(+) m6A 5'UTR//intron       25456834//27371828//27773536//22608085 chr16:28874867-28874868(+) m6A 5'UTR//intron       24284625//24981863//22608085 chr16:28875254-28875255(+) m6A 5'UTR//exon//intron       - chr16:28875271-28875272(+) m6A 5'UTR//intron       - chr16:28875277-28875278(+) m6A 5'UTR//intron       - chr16:28875283-28875284(+) m6A 5'UTR//intron       - chr16:28875409-28875410(+) m6A 5'UTR//intron       24284625//25456834//24981863//22608085 chr16:28875495-28875496(+) m6A 5'UTR//intron       24284625//25456834//24981863//22608085 chr16:28875570-28875571(+) m6A 5'UTR//intron       24284625//25456834//24981863//22608085 chr16:28875631-28875632(+) m6A 5'UTR//intron       25456834//24981863//22608085 chr16:28876508-28876509(+) m6A 5'UTR//intron       22608085 chr16:28876565-28876566(+) m6A 5'UTR//intron       24981863//22608085 chr16:28876634-28876635(+) m6A 5'UTR//intron       24981863//22608085 chr16:28876655-28876656(+) m6A 5'UTR//intron       24981863 chr16:28876930-28876931(+) m6A 5'UTR//intron       - chr16:28877533-28877534(+) m6A CDS//intron       24284625//24981863 chr16:28877797-28877798(+) m6A CDS//intron       24284625 chr16:28877937-28877938(+) m6A CDS//intron       24284625//25456834//24981863//22608085 chr16:28877973-28877974(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22608085 chr16:28878004-28878005(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr16:28878036-28878037(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr16:28878050-28878051(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr16:28878087-28878088(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr16:28878110-28878111(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr16:28878519-28878520(+) m6A 5'UTR//intron       - chr16:28878702-28878703(+) m6A 5'UTR//CDS//intron       24284625 chr16:28878724-28878725(+) Cm CDS//intron       - chr16:28878736-28878737(+) m6A CDS//intron       24284625 chr16:28880356-28880357(+) m6A CDS//intron       24284625 chr16:28880580-28880581(+) m6A CDS//exon//intron       24284625 chr16:28880602-28880603(+) m6A CDS//exon//intron       24284625 chr16:28880608-28880609(+) m6A CDS//exon//intron       24284625 chr16:28880659-28880660(+) m6A CDS//exon//intron       24284625 chr16:28880672-28880673(+) m6A CDS//exon//intron       24284625 chr16:28883121-28883122(+) m6A CDS//exon//intron       24284625 chr16:28883188-28883189(+) m6A CDS//exon//intron       24284625 chr16:28883233-28883234(+) m6A CDS//exon//intron       24284625 chr16:28883246-28883247(+) m6A CDS//exon//intron       24284625 chr16:28883283-28883284(+) m6A CDS//exon//intron       - chr16:28883294-28883295(+) m6A CDS//exon//intron       - chr16:28883909-28883910(+) Y CDS//intron       25219674//26075521 chr16:28884804-28884805(+) m6A 3'UTR//CDS//exon       24284625//25456834//24981863 chr16:28884817-28884818(+) m6A 3'UTR//CDS//exon       24284625//25456834//24981863//27371828 chr16:28885170-28885171(+) m6A 3'UTR       24284625 chr16:28885208-28885209(+) m6A 3'UTR       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	SH2B1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: SH2B1

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.