Basic Information:
VIRBase ID: VHID00509780
Virus: Human herpesvirus 5 strain AD169
Host: Homo sapiens
Confidence Score: 0.7903
Interaction Type: Virus-Host interaction
Predicted Binding:
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Interactor Information:
Interactor1
Interactor2
Symbol
hcmv-miR-US25-1-5p
CLIC4
miRBase Accession/Entrez ID
MIMAT0001581
25932
Organism
Human herpesvirus 5 strain AD169
Homo sapiens
Category
miRNA
mRNA
Alias
-
CLIC4L//H1//huH1//MTCLIC//p64H1
RNA Editing:
Resource
Symbol
Editing Position
Change
Genetic Region
RADAR
CLIC4
Resource
Symbol
Editing Position
Change
SeqReg
exReg
PMID
DARNED
CLIC4
RNA Modification:
Resource
Symbol
ModificationPosition
Type
Genomic Context
PMID
RMBase
CLIC4
RNA Localization:
Resource
Symbol
Subcellular Localization
Tissue or Cell Line
PMID
RNALocate
CLIC4
Interaction Network (The top 100 interactions) :
Interactor1: hcmv-miR-US25-1-5p
Interactor2: CLIC4
Evidence Support:
Strong-Evidence
RISC-IP
Prediction-Evidence
miRanda//PITA
Support Database
ViRBase//VmiReg
References:
PMID
20585629
Target region
5'UTR
Source
ViRBase//VmiReg
Interactor1 expression
None
Tissue or cell line
HEK293 cells
Interactor2 expression
None
Description
Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.