Basic Information:

  VIRBase ID:  

VHID00509618

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          CEMIP2:  NM_001135820     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	CEMIP2
miRBase Accession/Entrez ID	MIMAT0001581	23670
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	TMEM2

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CEMIP2	chr9:74356307(-) A-I      intronic chr9:74356651(-) A-I      intronic chr9:74322937(-) A-I      intronic chr9:74322935(-) A-I      intronic chr9:74321830(-) A-I      intronic chr9:74321779(-) A-I      intronic chr9:74321069(-) A-I      intronic chr9:74302730(-) A-I      intronic chr9:74356843(-) A-I      intronic chr9:74356326(-) A-I      intronic chr9:74321063(-) A-I      intronic chr9:74321062(-) A-I      intronic chr9:74356290(-) A-I      intronic chr9:74321123(-) A-I      intronic chr9:74320981(-) A-I      intronic chr9:74320979(-) A-I      intronic chr9:74320901(-) A-I      intronic chr9:74356291(-) A-I      intronic chr9:74303411(-) A-I      intronic chr9:74303416(-) A-I      intronic chr9:74303433(-) A-I      intronic chr9:74306123(-) A-I      intronic chr9:74306127(-) A-I      intronic chr9:74306132(-) A-I      intronic chr9:74306137(-) A-I      intronic chr9:74306163(-) A-I      intronic chr9:74321855(-) A-I      intronic chr9:74356289(-) A-I      intronic chr9:74356254(-) A-I      intronic chr9:74356251(-) A-I      intronic chr9:74302865(-) A-I      intronic chr9:74302870(-) A-I      intronic chr9:74302878(-) A-I      intronic chr9:74353307(-) A-I      intronic chr9:74344528(-) A-I      intronic chr9:74317111(-) A-I      intronic chr9:74317079(-) A-I      intronic chr9:74317074(-) A-I      intronic chr9:74302884(-) A-I      intronic chr9:74316289(-) A-I      intronic chr9:74316286(-) A-I      intronic chr9:74316259(-) A-I      intronic chr9:74316199(-) A-I      intronic chr9:74316189(-) A-I      intronic chr9:74316160(-) A-I      intronic chr9:74316159(-) A-I      intronic chr9:74316154(-) A-I      intronic chr9:74316133(-) A-I      intronic chr9:74317066(-) A-I      intronic chr9:74307742(-) A-I      intronic chr9:74306290(-) A-I      intronic chr9:74303583(-) A-I      intronic chr9:74303550(-) A-I      intronic chr9:74303005(-) A-I      intronic chr9:74302864(-) A-I      intronic chr9:74303401(-) A-I      intronic chr9:74302699(-) A-I      intronic chr9:74302523(-) A-I      intronic chr9:74344478(-) A-I      intronic chr9:74344051(-) A-I      intronic chr9:74344045(-) A-I      intronic chr9:74344023(-) A-I      intronic chr9:74343077(-) A-I      intronic chr9:74303397(-) A-I      intronic chr9:74343031(-) A-I      intronic chr9:74323055(-) A-I      intronic chr9:74303410(-) A-I      intronic chr9:74322981(-) A-I      intronic chr9:74321919(-) A-I      intronic chr9:74322979(-) A-I      intronic chr9:74302526(-) A-I      intronic chr9:74303599(-) A-I      intronic chr9:74302880(-) A-I      intronic chr9:74321914(-) A-I      intronic chr9:74302897(-) A-I      intronic chr9:74344508(-) A-I      intronic chr9:74316198(-) A-I      intronic chr9:74322913(-) A-I      intronic chr9:74302553(-) A-I      intronic chr9:74343286(-) A-I      intronic chr9:74309115(-) A-I      intronic chr9:74344029(-) A-I      intronic chr9:74317140(-) A-I      intronic chr9:74343815(-) A-I      intronic chr9:74321915(-) A-I      intronic chr9:74333668(-) A-I      intronic chr9:74370628(-) A-I      intronic chr9:74356821(-) A-I      intronic chr9:74343037(-) A-I      intronic chr9:74359073(-) A-I      intronic chr9:74333666(-) A-I      intronic chr9:74302706(-) A-I      intronic chr9:74320960(-) A-I      intronic chr9:74343850(-) A-I      intronic chr9:74343392(-) A-I      intronic chr9:74365900(-) A-I      intronic chr9:74370262(-) A-I      intronic chr9:74322857(-) A-I      intronic chr9:74343786(-) A-I      intronic chr9:74322017(-) A-I      intronic chr9:74316294(-) A-I      intronic chr9:74351919(-) A-I      intronic chr9:74344037(-) A-I      intronic chr9:74321836(-) A-I      intronic chr9:74302500(-) A-I      intronic chr9:74321023(-) A-I      intronic chr9:74344472(-) A-I      intronic chr9:74344279(-) A-I      intronic chr9:74356286(-) A-I      intronic chr9:74344346(-) A-I      intronic chr9:74302889(-) A-I      intronic chr9:74333631(-) A-I      intronic chr9:74348943(-) A-I      intronic chr9:74343840(-) A-I      intronic chr9:74306114(-) A-I      intronic chr9:74303443(-) A-I      intronic chr9:74344354(-) A-I      intronic chr9:74348942(-) A-I      intronic chr9:74343949(-) A-I      intronic chr9:74321873(-) A-I      intronic chr9:74302527(-) A-I      intronic chr9:74359088(-) A-I      intronic chr9:74321841(-) A-I      intronic chr9:74322921(-) A-I      intronic chr9:74302991(-) A-I      intronic chr9:74317143(-) A-I      intronic chr9:74303064(-) A-I      intronic chr9:74310369(-) A-I      intronic chr9:74307707(-) A-I      intronic chr9:74321882(-) A-I      intronic chr9:74309318(-) A-I      intronic chr9:74344028(-) A-I      intronic chr9:74310328(-) A-I      intronic chr9:74321840(-) A-I      intronic chr9:74302470(-) A-I      intronic

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	CEMIP2	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: CEMIP2

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.