Basic Information:

  VIRBase ID:  

VHID00509525

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          MMD:  NM_012329     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	MMD
miRBase Accession/Entrez ID	MIMAT0001581	23531
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	MMA//MMD1//PAQR11

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MMD	chr17:53483893(-) A-I      intronic chr17:53475134(-) A-I      intronic chr17:53486222(-) A-I      intronic chr17:53477833(-) A-I      intronic chr17:53474601(-) A-I      intronic chr17:53482729(-) A-I      intronic chr17:53477847(-) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MMD	chr17:53471027-53471028(-) m6A 3'UTR       27773535 chr17:53471042-53471043(-) m6A 3'UTR       27773535 chr17:53471103-53471104(-) m6A 3'UTR       27773535 chr17:53471213-53471214(-) m6A 3'UTR       27773535 chr17:53471426-53471427(-) m6A 3'UTR       24981863 chr17:53471431-53471432(-) m6A 3'UTR       24981863 chr17:53471454-53471455(-) m6A 3'UTR       24981863 chr17:53471465-53471466(-) m6A 3'UTR       24981863 chr17:53497667-53497668(-) m6A exon//intron       24209618//27371828//22608085 chr17:53497670-53497671(-) Am exon//intron       - chr17:53497687-53497688(-) m6A exon//intron       24209618//22608085 chr17:53497709-53497710(-) m6A exon//intron       24209618//24981863//22608085 chr17:53497742-53497743(-) m6A exon//intron       24209618//24981863//22608085 chr17:53497814-53497815(-) m6A exon//intron       27773536//22608085 chr17:53499161-53499162(-) m6A 5'UTR       24981863//27371828//27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	MMD	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleus HCC cell line (HepG2)     - Ribosome HEK-293 cells     22199352 Ribosome-free cytosol Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: MMD

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.