Detail Information

Basic Information:


  VIRBase ID:  

VHID00509502

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           ZFYVE26:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p ZFYVE26
miRBase
Accession/Entrez ID		 MIMAT0001581 23503
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - FYVE-CENT//SPG15

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ZFYVE26
chr14:68225522(-) A-I      intronic
chr14:68199390(-) A-I      intronic
chr14:68227411(-) A-I      intronic
chr14:68209771(-) A-I      intronic
chr14:68199431(-) A-I      intronic
chr14:68227414(-) A-I      intronic
chr14:68209725(-) A-I      intronic
chr14:68199383(-) A-I      intronic
chr14:68225521(-) A-I      intronic
chr14:68209753(-) A-I      intronic
chr14:68199399(-) A-I      intronic
chr14:68203847(-) A-I      intronic
chr14:68225789(-) A-I      intronic
chr14:68224635(-) A-I      intronic
chr14:68199554(-) A-I      intronic
chr14:68209961(-) A-I      intronic
chr14:68210096(-) A-I      intronic
chr14:68226078(-) A-I      intronic
chr14:68198627(-) A-I      intronic
chr14:68198761(-) A-I      intronic
chr14:68246157(-) A-I      intronic
chr14:68224630(-) A-I      intronic
chr14:68226315(-) A-I      intronic
chr14:68198762(-) A-I      intronic
chr14:68225425(-) A-I      intronic
chr14:68225850(-) A-I      intronic
chr14:68209733(-) A-I      intronic
chr14:68225918(-) A-I      intronic
chr14:68225838(-) A-I      intronic
chr14:68224696(-) A-I      intronic
chr14:68246769(-) A-I      intronic
chr14:68209805(-) A-I      intronic
chr14:68227350(-) A-I      intronic
chr14:68246171(-) A-I      intronic
chr14:68225547(-) A-I      intronic
chr14:68246233(-) A-I      intronic
chr14:68224570(-) A-I      intronic
chr14:68225438(-) A-I      intronic
chr14:68226192(-) A-I      intronic
chr14:68224547(-) A-I      intronic
chr14:68225491(-) A-I      intronic
chr14:68199321(-) A-I      intronic
chr14:68226178(-) A-I      intronic
chr14:68225501(-) A-I      intronic
chr14:68246649(-) A-I      intronic
chr14:68224524(-) A-I      intronic
chr14:68199438(-) A-I      intronic
chr14:68246277(-) A-I      intronic
chr14:68246296(-) A-I      intronic
chr14:68225598(-) A-I      intronic
chr14:68246284(-) A-I      intronic
chr14:68226281(-) A-I      intronic
chr14:68246760(-) A-I      intronic
chr14:68224499(-) A-I      intronic
chr14:68212563(-) A-I      intronic
chr14:68261622(-) A-I      intronic
chr14:68225558(-) A-I      intronic
chr14:68225792(-) A-I      intronic
chr14:68198069(-) A-I      intronic
chr14:68261660(-) A-I      intronic
chr14:68198043(-) A-I      intronic
chr14:68197999(-) A-I      intronic
chr14:68197997(-) A-I      intronic
chr14:68269838(-) A-I      intronic
chr14:68209571(-) A-I      intronic
chr14:68204559(-) A-I      intronic
chr14:68227388(-) A-I      intronic
chr14:68199498(-) A-I      intronic
chr14:68226175(-) A-I      intronic
chr14:68246155(-) A-I      intronic
chr14:68210002(-) A-I      intronic
chr14:68259517(-) A-I      intronic
chr14:68269902(-) A-I      intronic
chr14:68209624(-) A-I      intronic
chr14:68226257(-) A-I      intronic
chr14:68246167(-) A-I      intronic
chr14:68225767(-) A-I      intronic
chr14:68225517(-) A-I      intronic
chr14:68225485(-) A-I      intronic
chr14:68220946(-) A-I      intronic
chr14:68225631(-) A-I      intronic
chr14:68246240(-) A-I      intronic
chr14:68209730(-) A-I      intronic
chr14:68209685(-) A-I      intronic
chr14:68209787(-) A-I      intronic
chr14:68198626(-) A-I      intronic
chr14:68246123(-) A-I      intronic
chr14:68225520(-) A-I      intronic
chr14:68227369(-) A-I      intronic
chr14:68246290(-) A-I      intronic
chr14:68204978(-) A-I      intronic
chr14:68246768(-) A-I      intronic
chr14:68210145(-) A-I      intronic
chr14:68246727(-) A-I      intronic
chr14:68209729(-) A-I      intronic
chr14:68224469(-) A-I      intronic
chr14:68209642(-) A-I      intronic
chr14:68203864(-) A-I      intronic
chr14:68225846(-) A-I      intronic
chr14:68209829(-) A-I      intronic
chr14:68203817(-) A-I      intronic
chr14:68225490(-) A-I      intronic
chr14:68225608(-) A-I      intronic
chr14:68210073(-) A-I      intronic
chr14:68226289(-) A-I      intronic
chr14:68199386(-) A-I      intronic
chr14:68273805(-) A-I      intronic
chr14:68225837(-) A-I      intronic
chr14:68209721(-) A-I      intronic
chr14:68225840(-) A-I      intronic
chr14:68259384(-) A-I      intronic
chr14:68225557(-) A-I      intronic
chr14:68209754(-) A-I      intronic
chr14:68225712(-) A-I      intronic
chr14:68210125(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED ZFYVE26
chr14:68262981(-) A-I intron -    15342557
chr14:68262986(-) A-I intron -    15342557
chr14:68263036(-) A-I intron -    15342557
chr14:68263039(-) A-I intron -    15342557
chr14:68263045(-) A-I intron -    15342557
chr14:68263091(-) A-I intron -    15342557
chr14:68263099(-) A-I intron -    15342557
chr14:68263100(-) A-I intron -    15342557
chr14:68263101(-) A-I intron -    15342557
chr14:68263105(-) A-I intron -    15342557
chr14:68263116(-) A-I intron -    15342557
chr14:68263118(-) A-I intron -    15342557
chr14:68263122(-) A-I intron -    15342557
chr14:68263126(-) A-I intron -    15342557
chr14:68263136(-) A-I intron -    15342557
chr14:68263150(-) A-I intron -    15342557
chr14:68263155(-) A-I intron -    15342557
chr14:68263169(-) A-I intron -    15342557
chr14:68263202(-) A-I intron -    15342557
chr14:68263424(-) A-I intron -    15342557
chr14:68263425(-) A-I intron -    15342557
chr14:68263477(-) A-I intron -    15342557
chr14:68263486(-) A-I intron -    15342557
chr14:68263503(-) A-I intron -    15342557
chr14:68263506(-) A-I intron -    15342557
chr14:68263582(-) A-I intron -    15342557
chr14:68263583(-) A-I intron -    15342557
chr14:68263617(-) A-I intron -    15342557
chr14:68263643(-) A-I intron -    15342557
chr14:68225520(-) A-G intron -    22484847
chr14:68263202(-) A-G intron -    22484847
chr14:68263583(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ZFYVE26
chr14:68213267-68213268(-) m6A 3'UTR//intron       27773535
chr14:68213306-68213307(-) m6A 3'UTR//intron       27773535
chr14:68213317-68213318(-) m6A 3'UTR//intron       27773535
chr14:68213345-68213346(-) m6A 3'UTR//intron       27773535
chr14:68213376-68213377(-) m6A 3'UTR//intron       24981863//27773535
chr14:68213406-68213407(-) m6A 3'UTR//intron       24981863//27773535
chr14:68213442-68213443(-) m6A 3'UTR//intron       24981863//27773535
chr14:68213499-68213500(-) m6A 3'UTR//intron       24981863//27773535
chr14:68213617-68213618(-) m6A 3'UTR//intron       24981863
chr14:68213625-68213626(-) m6A 3'UTR//intron       24981863
chr14:68213636-68213637(-) m6A 3'UTR//intron       24981863
chr14:68214988-68214989(-) m6A 3'UTR//exon//intron       24209618//25456834//24981863//27773535//27371828//22608085
chr14:68215018-68215019(-) m6A 3'UTR//exon//intron       24209618//25456834//24981863//27773535//27371828//22608085
chr14:68215059-68215060(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//28052920//27371828//22608085
chr14:68215130-68215131(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085
chr14:68215219-68215220(-) m6A 3'UTR//CDS//exon//intron       24209618//25456834//24981863//27371828//27773536//22575960//22608085
chr14:68215293-68215294(-) m6A 3'UTR//CDS//exon//intron       27773535//22608085
chr14:68215329-68215330(-) m6A 3'UTR//CDS//exon//intron       27773535
chr14:68227932-68227933(-) m6A 3'UTR//intron       24284625//27773535//22608085
chr14:68227939-68227940(-) m6A 3'UTR//intron       24284625//24981863//27773535//22608085
chr14:68228006-68228007(-) m6A CDS//intron       24284625//25456834//24981863//27773535//22608085
chr14:68228026-68228027(-) m6A CDS//intron       24284625//25456834//24981863//27773535//22608085
chr14:68228070-68228071(-) m6A CDS//intron       24284625//25456834//24981863//27773535//22608085
chr14:68228076-68228077(-) m6A CDS//intron       24284625//25456834//24981863//27773535//22608085
chr14:68228203-68228204(-) m6A 3'UTR//CDS//exon       27773535
chr14:68228268-68228269(-) m6A 3'UTR//CDS//exon       27773535
chr14:68241780-68241781(-) m6A 3'UTR//CDS//exon       -
chr14:68244329-68244330(-) m6A 3'UTR//CDS//exon       27773535
chr14:68244914-68244915(-) m6A 3'UTR//CDS//exon       27773535
chr14:68249785-68249786(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22608085
chr14:68249854-68249855(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//22608085
chr14:68249875-68249876(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//22608085
chr14:68249987-68249988(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//22608085
chr14:68250026-68250027(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//22608085
chr14:68250036-68250037(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//22608085
chr14:68250132-68250133(-) m6A 3'UTR//CDS//exon       24284625//24209618//27773535
chr14:68251849-68251850(-) m6A 3'UTR//CDS//exon       27773536
chr14:68251878-68251879(-) m6A 3'UTR//CDS//exon       27773536
chr14:68251888-68251889(-) m6A 3'UTR//CDS//exon       27773536
chr14:68251907-68251908(-) m6A 3'UTR//CDS//exon       27773536
chr14:68251985-68251986(-) m6A 3'UTR//CDS//exon       24284625//27773536
chr14:68262985-68262986(-) m6A exon//intron       24981863
chr14:68264406-68264407(-) m6A 3'UTR//CDS//exon       27371828//27773536
chr14:68264761-68264762(-) m6A 3'UTR//CDS//exon       27371828//27773536
chr14:68264815-68264816(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//27371828//27773536//22608085
chr14:68264971-68264972(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22608085
chr14:68264978-68264979(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22608085
chr14:68265014-68265015(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085
chr14:68265060-68265061(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085
chr14:68265185-68265186(-) m6A 3'UTR//CDS//exon       24284625//24981863//22608085
chr14:68265248-68265249(-) m6A 3'UTR//CDS//exon       24284625//24981863//22608085
chr14:68268842-68268843(-) m6A CDS//exon//intron       27773535
chr14:68268857-68268858(-) m6A CDS//exon//intron       27773535
chr14:68268866-68268867(-) m6A CDS//exon//intron       27773535
chr14:68268893-68268894(-) m6A CDS//exon//intron       27773535
chr14:68274255-68274256(-) m6A CDS//exon       25456834//27773536//22608085
chr14:68274274-68274275(-) m6A CDS//exon       25456834//24981863//27773536//22608085
chr14:68274310-68274311(-) m6A CDS//exon       25456834//24981863//27371828//27773536//22608085
chr14:68274330-68274331(-) m6A CDS//exon       25456834//24981863//27371828//22608085
chr14:68274416-68274417(-) m6A CDS//exon       25456834//24981863//27371828//22608085
chr14:68282742-68282743(-) m6A 5'UTR//exon       24981863
chr14:68283294-68283295(-) m6A 5'UTR//exon       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate ZFYVE26
Chromatin K562 cells     -
Cytosol K562 cells     -
Exosome Blood     -
Membrane K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: ZFYVE26

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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