Basic Information:

  VIRBase ID:  

VHID00509408

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          ARHGEF12:  NM_001198665     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	ARHGEF12
miRBase Accession/Entrez ID	MIMAT0001581	23365
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	LARG//PRO2792

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ARHGEF12	chr11:120221879(+) A-I      intronic chr11:120304409(+) A-I      intronic chr11:120304447(+) A-I      intronic chr11:120304431(+) A-I      intronic chr11:120304445(+) A-I      intronic chr11:120265557(+) A-I      intronic chr11:120221852(+) A-I      intronic chr11:120304432(+) A-I      intronic chr11:120221873(+) A-I      intronic chr11:120320227(+) A-I      intronic chr11:120320221(+) A-I      intronic chr11:120228436(+) A-I      intronic chr11:120228421(+) A-I      intronic chr11:120228420(+) A-I      intronic chr11:120228418(+) A-I      intronic chr11:120228310(+) A-I      intronic chr11:120228302(+) A-I      intronic chr11:120222445(+) A-I      intronic chr11:120222443(+) A-I      intronic chr11:120221984(+) A-I      intronic chr11:120221881(+) A-I      intronic chr11:120221880(+) A-I      intronic chr11:120221851(+) A-I      intronic chr11:120296125(+) A-I      intronic chr11:120239869(+) A-I      intronic chr11:120239052(+) A-I      intronic chr11:120304588(+) A-I      intronic chr11:120316336(+) A-I      intronic chr11:120320365(+) A-I      intronic chr11:120298156(+) A-I      intronic chr11:120265125(+) A-I      intronic chr11:120320841(+) A-I      intronic chr11:120237605(+) A-I      intronic chr11:120259785(+) A-I      intronic chr11:120239977(+) A-I      intronic chr11:120297792(+) A-I      intronic chr11:120231341(+) A-I      intronic chr11:120265566(+) A-I      intronic chr11:120237129(+) A-I      intronic chr11:120238494(+) A-I      intronic chr11:120239032(+) A-I      intronic chr11:120309604(+) A-I      intronic chr11:120253594(+) A-I      intronic chr11:120214773(+) A-I      intronic chr11:120228365(+) A-I      intronic chr11:120238204(+) A-I      intronic chr11:120265088(+) A-I      intronic chr11:120320261(+) A-I      intronic chr11:120321952(+) A-I      intronic chr11:120296198(+) A-I      intronic chr11:120298310(+) A-I      intronic chr11:120298150(+) A-I      intronic chr11:120298178(+) A-I      intronic chr11:120265675(+) A-I      intronic chr11:120253754(+) A-I      intronic chr11:120297817(+) A-I      intronic chr11:120239086(+) A-I      intronic chr11:120265707(+) A-I      intronic chr11:120265708(+) A-I      intronic chr11:120221077(+) A-I      intronic chr11:120231337(+) A-I      intronic chr11:120298306(+) A-I      intronic chr11:120265646(+) A-I      intronic chr11:120352538(+) A-I      intronic chr11:120352533(+) A-I      intronic chr11:120328088(+) A-I      intronic chr11:120328079(+) A-I      intronic chr11:120328076(+) A-I      intronic chr11:120322122(+) A-I      intronic chr11:120322029(+) A-I      intronic chr11:120321043(+) A-I      intronic chr11:120320962(+) A-I      intronic chr11:120320328(+) A-I      intronic chr11:120320293(+) A-I      intronic chr11:120320246(+) A-I      intronic chr11:120320226(+) A-I      intronic chr11:120320198(+) A-I      intronic chr11:120320192(+) A-I      intronic chr11:120320181(+) A-I      intronic chr11:120320155(+) A-I      intronic chr11:120306293(+) A-I      intronic chr11:120306288(+) A-I      intronic chr11:120306287(+) A-I      intronic chr11:120298216(+) A-I      intronic chr11:120298165(+) A-I      intronic chr11:120297868(+) A-I      intronic chr11:120297787(+) A-I      intronic chr11:120297666(+) A-I      intronic chr11:120296286(+) A-I      intronic chr11:120265753(+) A-I      intronic chr11:120265571(+) A-I      intronic chr11:120265503(+) A-I      intronic chr11:120265143(+) A-I      intronic chr11:120265140(+) A-I      intronic chr11:120265021(+) A-I      intronic chr11:120259646(+) A-I      intronic chr11:120259615(+) A-I      intronic chr11:120244666(+) A-I      intronic chr11:120244646(+) A-I      intronic chr11:120242077(+) A-I      intronic chr11:120240035(+) A-I      intronic chr11:120240018(+) A-I      intronic chr11:120240010(+) A-I      intronic chr11:120239950(+) A-I      intronic chr11:120239942(+) A-I      intronic chr11:120239938(+) A-I      intronic chr11:120239114(+) A-I      intronic chr11:120239015(+) A-I      intronic chr11:120238979(+) A-I      intronic chr11:120238554(+) A-I      intronic chr11:120238550(+) A-I      intronic chr11:120238451(+) A-I      intronic chr11:120238431(+) A-I      intronic chr11:120238128(+) A-I      intronic chr11:120237572(+) A-I      intronic chr11:120237571(+) A-I      intronic chr11:120237559(+) A-I      intronic chr11:120237528(+) A-I      intronic chr11:120236836(+) A-I      intronic chr11:120236819(+) A-I      intronic chr11:120236816(+) A-I      intronic chr11:120236814(+) A-I      intronic chr11:120236789(+) A-I      intronic chr11:120236752(+) A-I      intronic chr11:120233688(+) A-I      intronic chr11:120233632(+) A-I      intronic chr11:120233631(+) A-I      intronic chr11:120233560(+) A-I      intronic chr11:120233555(+) A-I      intronic chr11:120221926(+) A-I      intronic chr11:120233554(+) A-I      intronic chr11:120231241(+) A-I      intronic chr11:120231231(+) A-I      intronic chr11:120231126(+) A-I      intronic chr11:120230062(+) A-I      intronic chr11:120338219(+) A-I      intronic chr11:120230971(+) A-I      intronic chr11:120264960(+) A-I      intronic chr11:120304516(+) A-I      intronic chr11:120238997(+) A-I      intronic chr11:120301878(+) A-I      intronic chr11:120265581(+) A-I      intronic chr11:120264947(+) A-I      intronic chr11:120296123(+) A-I      intronic chr11:120296097(+) A-I      intronic chr11:120238425(+) A-I      intronic chr11:120234753(+) A-I      intronic chr11:120238424(+) A-I      intronic chr11:120238335(+) A-I      intronic chr11:120273961(+) A-I      intronic chr11:120320258(+) A-I      intronic chr11:120231125(+) A-I      intronic chr11:120320378(+) A-I      intronic chr11:120298157(+) A-I      intronic chr11:120298119(+) A-I      intronic chr11:120298391(+) A-I      intronic chr11:120214890(+) A-I      intronic chr11:120352733(+) A-I      intronic chr11:120234292(+) A-I      intronic chr11:120231374(+) A-I      intronic chr11:120239087(+) A-I      intronic chr11:120298179(+) A-I      intronic chr11:120240112(+) A-I      intronic chr11:120265114(+) A-I      intronic chr11:120298211(+) A-I      intronic chr11:120304654(+) A-I      intronic chr11:120297784(+) A-I      intronic chr11:120353200(+) A-I      intronic chr11:120238560(+) A-I      intronic chr11:120296204(+) A-I      intronic chr11:120265639(+) A-I      intronic chr11:120274055(+) A-I      intronic chr11:120259649(+) A-I      intronic chr11:120265170(+) A-I      intronic chr11:120265729(+) A-I      intronic chr11:120238518(+) A-I      intronic chr11:120298302(+) A-I      intronic chr11:120230027(+) A-I      intronic chr11:120265511(+) A-I      intronic chr11:120236718(+) A-I      intronic chr11:120320297(+) A-I      intronic chr11:120265529(+) A-I      intronic chr11:120320825(+) A-I      intronic chr11:120296258(+) A-I      intronic chr11:120216157(+) A-I      intronic chr11:120221871(+) A-I      intronic chr11:120297679(+) A-I      intronic chr11:120320193(+) A-I      intronic chr11:120320830(+) A-I      intronic chr11:120230896(+) A-I      intronic chr11:120344245(+) A-I      intronic chr11:120238552(+) A-I      intronic chr11:120338221(+) A-I      intronic chr11:120235686(+) A-I      intronic chr11:120231214(+) A-I      intronic chr11:120259763(+) A-I      intronic chr11:120238464(+) A-I      intronic chr11:120264999(+) A-I      intronic chr11:120231364(+) A-I      intronic chr11:120304547(+) A-I      intronic chr11:120227069(+) A-I      intronic chr11:120239907(+) A-I      intronic chr11:120226295(+) A-I      intronic chr11:120235731(+) A-I      intronic chr11:120309836(+) A-I      intronic chr11:120230914(+) A-I      intronic chr11:120214876(+) A-I      intronic chr11:120216265(+) A-I      intronic chr11:120238347(+) A-I      intronic chr11:120352517(+) A-I      intronic chr11:120237522(+) A-I      intronic chr11:120354404(+) A-I      intronic chr11:120320898(+) A-I      intronic chr11:120226309(+) A-I      intronic chr11:120322027(+) A-I      intronic chr11:120298241(+) A-I      intronic chr11:120222038(+) A-I      intronic chr11:120235622(+) A-I      intronic chr11:120231244(+) A-I      intronic chr11:120265638(+) A-I      intronic chr11:120240038(+) A-I      intronic chr11:120231219(+) A-I      intronic chr11:120240076(+) A-I      intronic chr11:120274064(+) A-I      intronic chr11:120237483(+) A-I      intronic chr11:120215964(+) A-I      intronic chr11:120237578(+) A-I      intronic chr11:120320368(+) A-I      intronic chr11:120226289(+) A-I      intronic chr11:120344253(+) A-I      intronic chr11:120265046(+) A-I      intronic chr11:120238214(+) A-I      intronic chr11:120259711(+) A-I      intronic chr11:120237523(+) A-I      intronic chr11:120298269(+) A-I      intronic chr11:120239955(+) A-I      intronic chr11:120354074(+) A-I      intronic chr11:120265565(+) A-I      intronic chr11:120238498(+) A-I      intronic chr11:120230059(+) A-I      intronic chr11:120235635(+) A-I      intronic chr11:120214924(+) A-I      intronic chr11:120298210(+) A-I      intronic chr11:120230140(+) A-I      intronic chr11:120297796(+) A-I      intronic chr11:120238530(+) A-I      intronic chr11:120214925(+) A-I      intronic chr11:120304436(+) A-I      intronic chr11:120214881(+) A-I      intronic chr11:120273960(+) A-I      intronic chr11:120231133(+) A-I      intronic chr11:120230037(+) A-I      intronic chr11:120265520(+) A-I      intronic chr11:120295886(+) A-I      intronic chr11:120229957(+) A-I      intronic chr11:120237102(+) A-I      intronic chr11:120227803(+) A-I      intronic chr11:120265059(+) A-I      intronic chr11:120265645(+) A-I      intronic chr11:120316457(+) A-I      intronic chr11:120320287(+) A-I      intronic chr11:120230151(+) A-I      intronic chr11:120253733(+) A-I      intronic chr11:120231195(+) A-I      intronic chr11:120222309(+) A-I      intronic chr11:120297837(+) A-I      intronic chr11:120253696(+) A-I      intronic chr11:120253701(+) A-I      intronic chr11:120320245(+) A-I      intronic chr11:120222380(+) A-I      intronic chr11:120238989(+) A-I      intronic chr11:120238531(+) A-I      intronic chr11:120230972(+) A-I      intronic chr11:120227124(+) A-I      intronic chr11:120239072(+) A-I      intronic chr11:120265754(+) A-I      intronic chr11:120304410(+) A-I      intronic chr11:120221929(+) A-I      intronic chr11:120231301(+) A-I      intronic chr11:120237548(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ARHGEF12	chr11:120214876(+) A-I intron -    15342557 chr11:120214881(+) A-I intron -    15342557 chr11:120214890(+) A-I intron -    15342557 chr11:120214924(+) A-I intron -    15342557 chr11:120214925(+) A-I intron -    15342557 chr11:120215964(+) A-I intron -    15342557 chr11:120297784(+) A-I intron -    15258596 chr11:120297792(+) A-I intron -    15258596 chr11:120298157(+) A-I intron -    15258596 chr11:120265646(+) A-G intron -    22484847 chr11:120296123(+) A-G intron -    22484847 chr11:120297679(+) A-G intron -    22484847 chr11:120297837(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ARHGEF12	chr11:120207719-120207720(+) m6A 5'UTR       - chr11:120207839-120207840(+) m6A 5'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:120207932-120207933(+) m6A 5'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:120276841-120276842(+) m6A 5'UTR//CDS//exon       - chr11:120278463-120278464(+) m6A 5'UTR//CDS//exon       - chr11:120278537-120278538(+) m6A exon//intron       - chr11:120300210-120300211(+) m6A CDS//exon       24981863 chr11:120300444-120300445(+) m6A CDS//exon       24981863 chr11:120300488-120300489(+) m6A CDS//exon       24981863 chr11:120302505-120302506(+) m6A CDS//exon       22575960 chr11:120302516-120302517(+) m6A CDS//exon       22575960 chr11:120302542-120302543(+) m6A CDS//exon       22575960 chr11:120302569-120302570(+) m6A CDS//exon       - chr11:120308059-120308060(+) m6A CDS//exon       - chr11:120308076-120308077(+) m6A CDS//exon       - chr11:120317674-120317675(+) m6A CDS//exon       24981863 chr11:120317704-120317705(+) m6A CDS//exon       24981863 chr11:120317721-120317722(+) m6A CDS//exon       24981863 chr11:120317727-120317728(+) m6A CDS//exon       24981863 chr11:120317753-120317754(+) m6A CDS//exon       24981863 chr11:120317764-120317765(+) m6A CDS//exon       24981863 chr11:120319207-120319208(+) m6A exon//intron       24981863 chr11:120319232-120319233(+) m6A exon//intron       24981863 chr11:120319240-120319241(+) m6A exon//intron       24981863 chr11:120319251-120319252(+) m6A exon//intron       24981863 chr11:120319885-120319886(+) m6A CDS//exon       24981863 chr11:120319897-120319898(+) m6A CDS//exon       24981863 chr11:120322293-120322294(+) m6A CDS//exon       22575960 chr11:120322301-120322302(+) m6A CDS//exon       22575960 chr11:120322342-120322343(+) m6A CDS//exon       22575960 chr11:120340089-120340090(+) m6A CDS//exon       24981863 chr11:120343787-120343788(+) Y CDS//exon       26075521 chr11:120348904-120348905(+) m6A CDS//exon       - chr11:120348970-120348971(+) m6A CDS//exon       24981863 chr11:120348985-120348986(+) m6A CDS//exon       - chr11:120348993-120348994(+) Cm CDS//exon       - chr11:120349001-120349002(+) m6A CDS//exon       - chr11:120350731-120350732(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:120350757-120350758(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:120350778-120350779(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:120350797-120350798(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:120350834-120350835(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:120350850-120350851(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:120350856-120350857(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:120350889-120350890(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:120350927-120350928(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:120350971-120350972(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:120351971-120351972(+) m6A CDS       24284625//24209618//24981863//22608085 chr11:120355902-120355903(+) m6A 3'UTR       24284625 chr11:120356210-120356211(+) m6A 3'UTR       24981863 chr11:120356744-120356745(+) m6A 3'UTR       24981863 chr11:120359567-120359568(+) m6A 3'UTR       27773535 chr11:120359649-120359650(+) m6A 3'UTR       27773535 chr11:120359671-120359672(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ARHGEF12	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Insoluble cytoplasm K562 cells     - Membrane HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: ARHGEF12

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.