Basic Information:

  VIRBase ID:  

VHID00509390

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          SZT2:  NM_001365999     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	SZT2
miRBase Accession/Entrez ID	MIMAT0001581	23334
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	C1orf84//DEE18//EIEE18//KIAA0467//KICS1//SZT2A//SZT2B

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SZT2	chr1:43899052(+) A-I      intronic chr1:43876068(+) A-I      3'UTR chr1:43876079(+) A-I      3'UTR chr1:43876138(+) A-I      3'UTR chr1:43903651(+) A-I      intronic chr1:43903676(+) A-I      intronic chr1:43876071(+) A-I      3'UTR chr1:43876115(+) A-I      3'UTR chr1:43865888(+) A-I      intronic chr1:43865735(+) A-I      intronic chr1:43865728(+) A-I      intronic chr1:43870805(+) A-I      intronic chr1:43865689(+) A-I      intronic chr1:43865679(+) A-I      intronic chr1:43865633(+) A-I      intronic chr1:43871807(+) A-I      intronic chr1:43865213(+) A-I      intronic chr1:43866649(+) A-I      intronic chr1:43865696(+) A-I      intronic chr1:43856726(+) A-I      intronic chr1:43862951(+) A-I      intronic chr1:43860444(+) A-I      intronic chr1:43857661(+) A-I      intronic chr1:43856761(+) A-I      intronic chr1:43856864(+) A-I      intronic chr1:43856810(+) A-I      intronic chr1:43863328(+) A-I      intronic chr1:43863324(+) A-I      intronic chr1:43862991(+) A-I      intronic chr1:43862983(+) A-I      intronic chr1:43864489(+) A-I      intronic chr1:43863340(+) A-I      intronic chr1:43862975(+) A-I      intronic chr1:43870804(+) A-I      intronic chr1:43869798(+) A-I      intronic chr1:43869671(+) A-I      intronic chr1:43866786(+) A-I      intronic chr1:43872021(+) A-I      3'UTR chr1:43876004(+) A-I      3'UTR chr1:43876167(+) A-I      3'UTR chr1:43875995(+) A-I      3'UTR chr1:43876051(+) A-I      3'UTR chr1:43876106(+) A-I      3'UTR chr1:43876176(+) A-I      3'UTR chr1:43876158(+) A-I      3'UTR chr1:43864686(+) A-I      intronic chr1:43864535(+) A-I      intronic chr1:43864692(+) A-I      intronic chr1:43864685(+) A-I      intronic chr1:43864726(+) A-I      intronic chr1:43864498(+) A-I      intronic chr1:43864536(+) A-I      intronic chr1:43864541(+) A-I      intronic chr1:43864640(+) A-I      intronic chr1:43864696(+) A-I      intronic chr1:43864620(+) A-I      intronic chr1:43864555(+) A-I      intronic chr1:43864701(+) A-I      intronic chr1:43864644(+) A-I      intronic chr1:43864630(+) A-I      intronic chr1:43864636(+) A-I      intronic chr1:43864733(+) A-I      intronic chr1:43864647(+) A-I      intronic chr1:43864533(+) A-I      intronic chr1:43864528(+) A-I      intronic chr1:43864714(+) A-I      intronic chr1:43864564(+) A-I      intronic chr1:43858292(+) A-I      intronic chr1:43861117(+) A-I      intronic chr1:43856937(+) A-I      intronic chr1:43875975(+) A-I      3'UTR chr1:43869817(+) A-I      intronic chr1:43865845(+) A-I      intronic chr1:43863299(+) A-I      intronic chr1:43858270(+) A-I      intronic chr1:43856739(+) A-I      intronic chr1:43860438(+) A-I      intronic chr1:43866796(+) A-I      intronic chr1:43866670(+) A-I      intronic chr1:43863047(+) A-I      intronic chr1:43862987(+) A-I      intronic chr1:43865846(+) A-I      intronic chr1:43864601(+) A-I      intronic chr1:43864503(+) A-I      intronic chr1:43903704(+) A-I      ncRNA chr1:43870951(+) A-I      intronic chr1:43866705(+) A-I      intronic chr1:43856865(+) A-I      intronic chr1:43864672(+) A-I      intronic chr1:43860429(+) A-I      intronic chr1:43903662(+) A-I      intronic chr1:43899438(+) A-I      intronic chr1:43861111(+) A-I      intronic chr1:43876105(+) A-I      3'UTR chr1:43903669(+) A-I      intronic chr1:43904011(+) A-I      intronic chr1:43862875(+) A-I      intronic chr1:43863462(+) A-I      intronic chr1:43904033(+) A-I      intronic chr1:43872004(+) A-I      3'UTR chr1:43875962(+) A-I      3'UTR chr1:43865873(+) A-I      intronic chr1:43869767(+) A-I      intronic chr1:43865394(+) A-I      intronic chr1:43903659(+) A-I      intronic chr1:43876021(+) A-I      3'UTR chr1:43860385(+) A-I      intronic chr1:43875969(+) A-I      3'UTR chr1:43863023(+) A-I      intronic chr1:43856800(+) A-I      intronic chr1:43903665(+) A-I      intronic chr1:43865743(+) A-I      intronic chr1:43875974(+) A-I      3'UTR chr1:43856821(+) A-I      intronic chr1:43863298(+) A-I      intronic chr1:43861082(+) A-I      intronic chr1:43860295(+) A-I      intronic chr1:43875946(+) A-I      3'UTR chr1:43862942(+) A-I      intronic chr1:43865736(+) A-I      intronic chr1:43866616(+) A-I      intronic chr1:43860469(+) A-I      intronic chr1:43862839(+) A-I      intronic chr1:43856940(+) A-I      intronic chr1:43863005(+) A-I      intronic chr1:43875968(+) A-I      3'UTR chr1:43862947(+) A-I      intronic chr1:43862948(+) A-I      intronic chr1:43875977(+) A-I      3'UTR chr1:43904085(+) A-I      intronic chr1:43869865(+) A-I      intronic chr1:43876036(+) A-I      3'UTR chr1:43871898(+) A-I      intronic chr1:43875990(+) A-I      3'UTR chr1:43865339(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SZT2	chr1:43904033(+) A-I intron -    22327324 chr1:43873011(+) A-I intron -    22327324 chr1:43883634(+) A-I intron -    22327324 chr1:43864498(+) A-I intron -    22028664 chr1:43864528(+) A-I intron -    22028664 chr1:43864533(+) A-I intron -    22028664 chr1:43864535(+) A-I intron -    22028664 chr1:43864536(+) A-I intron -    22028664 chr1:43864541(+) A-I intron -    22028664 chr1:43864555(+) A-I intron -    22028664 chr1:43864564(+) A-I intron -    22028664 chr1:43864620(+) A-I intron -    22028664 chr1:43864630(+) A-I intron -    22028664 chr1:43864636(+) A-I intron -    22028664 chr1:43864640(+) A-I intron -    22028664 chr1:43864644(+) A-I intron -    22028664 chr1:43864647(+) A-I intron -    22028664 chr1:43864685(+) A-I intron -    22028664 chr1:43864686(+) A-I intron -    22028664 chr1:43864692(+) A-I intron -    22028664 chr1:43864696(+) A-I intron -    22028664 chr1:43864701(+) A-I intron -    22028664 chr1:43864714(+) A-I intron -    22028664 chr1:43864726(+) A-I intron -    22028664 chr1:43864733(+) A-I intron -    22028664 chr1:43878066(+) A-I intron -    21960545 chr1:43878167(+) A-I intron -    21960545 chr1:43875995(+) A-G intron -    21725310 chr1:43883634(+) A-G intron -    22484847 chr1:43903659(+) A-G intron -    22484847 chr1:43903662(+) A-G intron -    22484847 chr1:43860429(+) A-G intron -    22484847 chr1:43860438(+) A-G intron -    22484847 chr1:43860469(+) A-G intron -    22484847 chr1:43862839(+) A-G intron -    22484847 chr1:43862875(+) A-G intron -    22484847 chr1:43862936(+) G-A intron -    22484847 chr1:43862987(+) A-G intron -    22484847 chr1:43863005(+) A-G intron -    22484847 chr1:43863299(+) A-G intron -    22484847 chr1:43863462(+) A-G intron -    22484847 chr1:43864503(+) A-G intron -    22484847 chr1:43865339(+) A-G intron -    22484847 chr1:43865394(+) A-G intron -    22484847 chr1:43865736(+) A-G intron -    22484847 chr1:43865743(+) A-G intron -    22484847 chr1:43870951(+) A-G intron -    22484847 chr1:43872937(+) A-G intron -    22484847 chr1:43872946(+) A-G intron -    22484847 chr1:43872966(+) A-G intron -    22484847 chr1:43873011(+) A-G intron -    22484847 chr1:43873012(+) A-G intron -    22484847 chr1:43873013(+) A-G intron -    22484847 chr1:43873067(+) A-G intron -    22484847 chr1:43873097(+) A-G intron -    22484847 chr1:43873099(+) A-G intron -    22484847 chr1:43873137(+) A-G intron -    22484847 chr1:43873243(+) A-G intron -    22484847 chr1:43873629(+) G-A intron -    22484847 chr1:43874004(+) A-G intron -    22484847 chr1:43874051(+) A-G intron -    22484847 chr1:43874073(+) A-G intron -    22484847 chr1:43874171(+) A-G intron -    22484847 chr1:43874172(+) A-G intron -    22484847 chr1:43874189(+) A-G intron -    22484847 chr1:43875946(+) A-G intron -    22484847 chr1:43877589(+) A-G intron -    22484847 chr1:43877634(+) A-G intron -    22484847 chr1:43878066(+) A-G intron -    22484847 chr1:43878084(+) A-G intron -    22484847 chr1:43878130(+) A-G intron -    22484847 chr1:43878167(+) A-G intron -    22484847 chr1:43878204(+) A-G intron -    22484847 chr1:43878231(+) A-G intron -    22484847 chr1:43878889(+) A-G intron -    22484847 chr1:43878892(+) A-G intron -    22484847 chr1:43878901(+) A-G intron -    22484847 chr1:43878933(+) A-G intron -    22484847 chr1:43878975(+) T-C intron -    22484847 chr1:43879901(+) A-G intron -    22484847 chr1:43899174(+) T-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SZT2	chr1:43855599-43855600(+) m6A 5'UTR//exon       24981863 chr1:43868854-43868855(+) m1A CDS//exon       26863196 chr1:43875598-43875599(+) m6A 3'UTR//exon//intron       24284625 chr1:43875608-43875609(+) m6A 3'UTR//exon//intron       24284625 chr1:43875639-43875640(+) m6A 3'UTR//exon//intron       24284625 chr1:43875648-43875649(+) m6A 3'UTR//exon//intron       24284625 chr1:43875706-43875707(+) m6A 3'UTR//exon//intron       24981863//22608085 chr1:43875728-43875729(+) m6A 3'UTR//exon//intron       24981863//22608085 chr1:43875740-43875741(+) m6A 3'UTR//exon//intron       24981863//22608085 chr1:43875749-43875750(+) m6A 3'UTR//exon//intron       24981863//22608085 chr1:43875761-43875762(+) m6A 3'UTR//exon//intron       24981863//22608085 chr1:43875787-43875788(+) m6A 3'UTR//exon//intron       24981863//22608085 chr1:43875811-43875812(+) m6A 3'UTR//exon//intron       24981863//22608085 chr1:43875829-43875830(+) m6A 3'UTR//exon//intron       24981863//22608085 chr1:43875859-43875860(+) m6A 3'UTR//exon//intron       24981863//22608085 chr1:43875887-43875888(+) m6A 3'UTR//exon//intron       22608085 chr1:43875892-43875893(+) m6A 3'UTR//exon//intron       22608085 chr1:43876736-43876737(+) Gm intron       - chr1:43886459-43886460(+) m6A CDS//exon       - chr1:43905599-43905600(+) m6A CDS       - chr1:43905627-43905628(+) m6A CDS       - chr1:43905707-43905708(+) m6A CDS       - chr1:43912665-43912666(+) m6A CDS//exon       - chr1:43912807-43912808(+) m6A CDS//exon       - chr1:43913217-43913218(+) m6A CDS//exon       - chr1:43913914-43913915(+) m6A CDS//exon       - chr1:43915822-43915823(+) m6A CDS//exon       24284625//24209618 chr1:43916053-43916054(+) m6A CDS//exon       24284625//24209618 chr1:43916136-43916137(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr1:43916159-43916160(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr1:43916164-43916165(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr1:43916224-43916225(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr1:43916259-43916260(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr1:43916327-43916328(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr1:43916341-43916342(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr1:43916368-43916369(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr1:43916396-43916397(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr1:43916469-43916470(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr1:43916570-43916571(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr1:43916583-43916584(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr1:43916610-43916611(+) Y 3'UTR//exon       26075521 chr1:43916670-43916671(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr1:43916771-43916772(+) m6A 3'UTR//exon       24284625//24209618//24981863//22608085 chr1:43916784-43916785(+) m6A 3'UTR//exon       24284625//24209618//24981863//22608085 chr1:43916815-43916816(+) m6A 3'UTR//exon       24284625//24209618//24981863 chr1:43917027-43917028(+) m6A 3'UTR//exon       27773535 chr1:43917140-43917141(+) m6A 3'UTR//exon       - chr1:43917193-43917194(+) m6A 3'UTR//exon       24981863 chr1:43917221-43917222(+) m6A 3'UTR//exon       24209618//24981863 chr1:43917231-43917232(+) m6A 3'UTR//exon       24209618//24981863 chr1:43917269-43917270(+) m6A 3'UTR//exon       24209618//24981863 chr1:43917333-43917334(+) m6A 3'UTR//exon       24981863 chr1:43917541-43917542(+) m6A 3'UTR//exon       27773535 chr1:43917575-43917576(+) m6A 3'UTR//exon       24981863//27773535 chr1:43917587-43917588(+) m6A 3'UTR//exon       24981863//27773535 chr1:43917840-43917841(+) m6A 3'UTR//exon       27773535 chr1:43917885-43917886(+) m6A 3'UTR//exon       27773535 chr1:43918005-43918006(+) m6A 3'UTR//exon       27773535//27371828//27773536 chr1:43918143-43918144(+) m6A 3'UTR//exon       24284625//27773535//27371828 chr1:43918181-43918182(+) m6A 3'UTR//exon       24284625//27773535 chr1:43918228-43918229(+) m6A 3'UTR//exon       24284625//24981863//27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	SZT2	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: SZT2

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.