Basic Information:

  VIRBase ID:  

VHID00509305

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          XPO6:  NM_001270940     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	XPO6
miRBase Accession/Entrez ID	MIMAT0001581	23214
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	EXP6//RANBP20

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	XPO6	chr16:28180055(-) A-I      intronic chr16:28147701(-) A-I      intronic chr16:28147669(-) A-I      intronic chr16:28179584(-) A-I      intronic chr16:28179742(-) A-I      intronic chr16:28180173(-) A-I      intronic chr16:28129864(-) A-I      intronic chr16:28129861(-) A-I      intronic chr16:28129860(-) A-I      intronic chr16:28177679(-) A-I      intronic chr16:28147745(-) A-I      intronic chr16:28153234(-) A-I      intronic chr16:28179562(-) A-I      intronic chr16:28147720(-) A-I      intronic chr16:28147719(-) A-I      intronic chr16:28147718(-) A-I      intronic chr16:28131341(-) A-I      intronic chr16:28131342(-) A-I      intronic chr16:28131345(-) A-I      intronic chr16:28131359(-) A-I      intronic chr16:28177717(-) A-I      intronic chr16:28177758(-) A-I      intronic chr16:28179747(-) A-I      intronic chr16:28211377(-) A-I      intronic chr16:28134512(-) A-I      intronic chr16:28133771(-) A-I      intronic chr16:28133698(-) A-I      intronic chr16:28131385(-) A-I      intronic chr16:28131370(-) A-I      intronic chr16:28131369(-) A-I      intronic chr16:28211395(-) A-I      intronic chr16:28177775(-) A-I      intronic chr16:28153194(-) A-I      intronic chr16:28134515(-) A-I      intronic chr16:28134526(-) A-I      intronic chr16:28134565(-) A-I      intronic chr16:28134656(-) A-I      intronic chr16:28134671(-) A-I      intronic chr16:28147673(-) A-I      intronic chr16:28147787(-) A-I      intronic chr16:28153114(-) A-I      intronic chr16:28153123(-) A-I      intronic chr16:28153159(-) A-I      intronic chr16:28154016(-) A-I      intronic chr16:28154069(-) A-I      intronic chr16:28154070(-) A-I      intronic chr16:28154072(-) A-I      intronic chr16:28173975(-) A-I      intronic chr16:28176532(-) A-I      intronic chr16:28176536(-) A-I      intronic chr16:28177706(-) A-I      intronic chr16:28179554(-) A-I      intronic chr16:28179602(-) A-I      intronic chr16:28179756(-) A-I      intronic chr16:28179924(-) A-I      intronic chr16:28180006(-) A-I      intronic chr16:28180038(-) A-I      intronic chr16:28180051(-) A-I      intronic chr16:28189723(-) A-I      intronic chr16:28189777(-) A-I      intronic chr16:28190612(-) A-I      intronic chr16:28190617(-) A-I      intronic chr16:28196674(-) A-I      intronic chr16:28196681(-) A-I      intronic chr16:28196682(-) A-I      intronic chr16:28197805(-) A-I      intronic chr16:28197814(-) A-I      intronic chr16:28197856(-) A-I      intronic chr16:28210239(-) A-I      intronic chr16:28210260(-) A-I      intronic chr16:28210378(-) A-I      intronic chr16:28210423(-) A-I      intronic chr16:28210814(-) A-I      intronic chr16:28210816(-) A-I      intronic chr16:28210879(-) A-I      intronic chr16:28210889(-) A-I      intronic chr16:28211020(-) A-I      intronic chr16:28211160(-) A-I      intronic chr16:28210262(-) A-I      intronic chr16:28147678(-) A-I      intronic chr16:28210221(-) A-I      intronic chr16:28190018(-) A-I      intronic chr16:28154030(-) A-I      intronic chr16:28196650(-) A-I      intronic chr16:28153092(-) A-I      intronic chr16:28221338(-) A-I      intronic chr16:28179543(-) A-I      intronic chr16:28210220(-) A-I      intronic chr16:28180209(-) A-I      intronic chr16:28210222(-) A-I      intronic chr16:28198108(-) A-I      intronic chr16:28210310(-) A-I      intronic chr16:28179762(-) A-I      intronic chr16:28177753(-) A-I      intronic chr16:28154068(-) A-I      intronic chr16:28134701(-) A-I      intronic chr16:28174076(-) A-I      intronic chr16:28179692(-) A-I      intronic chr16:28147760(-) A-I      intronic chr16:28153169(-) A-I      intronic chr16:28210720(-) A-I      intronic chr16:28210339(-) A-I      intronic chr16:28180039(-) A-I      intronic chr16:28180087(-) A-I      intronic chr16:28210764(-) A-I      intronic chr16:28180224(-) A-I      intronic chr16:28131295(-) A-I      intronic chr16:28188103(-) A-I      intronic chr16:28180215(-) A-I      intronic chr16:28198065(-) A-I      intronic chr16:28179601(-) A-I      intronic chr16:28179588(-) A-I      intronic chr16:28196581(-) A-I      intronic chr16:28211394(-) A-I      intronic chr16:28180163(-) A-I      intronic chr16:28131445(-) A-I      intronic chr16:28189717(-) A-I      intronic chr16:28179704(-) A-I      intronic chr16:28131412(-) A-I      intronic chr16:28176316(-) A-I      intronic chr16:28179795(-) A-I      intronic chr16:28179553(-) A-I      intronic chr16:28211915(-) A-I      intronic chr16:28197786(-) A-I      intronic chr16:28147679(-) A-I      intronic chr16:28159144(-) A-I      intronic chr16:28210766(-) A-I      intronic chr16:28134708(-) A-I      intronic chr16:28189879(-) A-I      intronic chr16:28147813(-) A-I      intronic chr16:28179561(-) A-I      intronic chr16:28180037(-) A-I      intronic chr16:28133868(-) A-I      intronic chr16:28179721(-) A-I      intronic chr16:28113896(-) A-I      intronic chr16:28179798(-) A-I      intronic chr16:28180034(-) A-I      intronic chr16:28133817(-) A-I      intronic chr16:28154985(-) A-I      intronic chr16:28210248(-) A-I      intronic chr16:28111562(-) A-I      intronic chr16:28179589(-) A-I      intronic chr16:28210353(-) A-I      intronic chr16:28159111(-) A-I      intronic chr16:28129877(-) A-I      intronic chr16:28210870(-) A-I      intronic chr16:28180047(-) A-I      intronic chr16:28180020(-) A-I      intronic chr16:28111446(-) A-I      intronic chr16:28154071(-) A-I      intronic chr16:28192941(-) A-I      intronic chr16:28189887(-) A-I      intronic chr16:28179632(-) A-I      intronic chr16:28198132(-) A-I      intronic chr16:28180076(-) A-I      intronic chr16:28197942(-) A-I      intronic chr16:28180144(-) A-I      intronic chr16:28211025(-) A-I      intronic chr16:28189885(-) A-I      intronic chr16:28179595(-) A-I      intronic chr16:28211365(-) A-I      intronic chr16:28154088(-) A-I      intronic chr16:28211026(-) A-I      intronic chr16:28179682(-) A-I      intronic chr16:28133751(-) A-I      intronic chr16:28217611(-) A-I      intronic chr16:28190222(-) A-I      intronic chr16:28180168(-) A-I      intronic chr16:28210235(-) A-I      intronic chr16:28179609(-) A-I      intronic chr16:28134591(-) A-I      intronic chr16:28210352(-) A-I      intronic chr16:28211137(-) A-I      intronic chr16:28189884(-) A-I      intronic chr16:28211355(-) A-I      intronic chr16:28211138(-) A-I      intronic chr16:28179549(-) A-I      intronic chr16:28133806(-) A-I      intronic chr16:28179695(-) A-I      intronic chr16:28179752(-) A-I      intronic chr16:28211908(-) A-I      intronic chr16:28147814(-) A-I      intronic chr16:28179988(-) A-I      intronic chr16:28201770(-) A-I      intronic chr16:28182534(-) A-I      intronic chr16:28170469(-) A-I      intronic chr16:28179991(-) A-I      intronic chr16:28176531(-) A-I      intronic chr16:28179680(-) A-I      intronic chr16:28179754(-) A-I      intronic chr16:28118948(-) A-I      NonSyn:Asn->Asp chr16:28210765(-) A-I      intronic chr16:28133812(-) A-I      intronic chr16:28180061(-) A-I      intronic chr16:28210285(-) A-I      intronic chr16:28197928(-) A-I      intronic chr16:28179571(-) A-I      intronic chr16:28179958(-) A-I      intronic chr16:28154006(-) A-I      intronic chr16:28173916(-) A-I      intronic chr16:28177714(-) A-I      intronic chr16:28113893(-) A-I      intronic chr16:28129909(-) A-I      intronic chr16:28199519(-) A-I      intronic chr16:28179934(-) A-I      intronic chr16:28179736(-) A-I      intronic chr16:28154065(-) A-I      intronic chr16:28212086(-) A-I      intronic chr16:28147608(-) A-I      intronic chr16:28210208(-) A-I      intronic chr16:28212068(-) A-I      intronic chr16:28153218(-) A-I      intronic chr16:28134674(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	XPO6	chr16:28118948(-) A-I exon CDS    19478186 chr16:28179798(-) A-I intron -    22327324 chr16:28180163(-) A-I intron -    22327324 chr16:28180215(-) A-I intron -    22327324 chr16:28180224(-) A-I intron -    22327324 chr16:28210208(-) A-I intron -    22028664 chr16:28210220(-) A-I intron -    22028664 chr16:28210221(-) A-I intron -    22028664 chr16:28210222(-) A-I intron -    22028664 chr16:28210235(-) A-I intron -    22028664 chr16:28210262(-) A-I intron -    22028664 chr16:28210285(-) A-I intron -    22028664 chr16:28210310(-) A-I intron -    22028664 chr16:28210339(-) A-I intron -    22028664 chr16:28210353(-) A-I intron -    22028664 chr16:28179752(-) A-G intron -    22484847 chr16:28179795(-) A-G intron -    22484847 chr16:28179798(-) A-G intron -    22484847 chr16:28179991(-) A-G intron -    22484847 chr16:28180034(-) A-G intron -    22484847 chr16:28180037(-) A-G intron -    22484847 chr16:28180087(-) A-G intron -    22484847 chr16:28180163(-) A-G intron -    22484847 chr16:28180215(-) A-G intron -    22484847 chr16:28180224(-) A-G intron -    22484847 chr16:28210720(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	XPO6	chr16:28109347-28109348(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085 chr16:28109394-28109395(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr16:28109472-28109473(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr16:28109531-28109532(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085 chr16:28109569-28109570(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr16:28109833-28109834(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr16:28109839-28109840(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr16:28109900-28109901(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr16:28112480-28112481(-) m6A 3'UTR//intron       24284625 chr16:28113199-28113200(-) m6A CDS//exon       27773535 chr16:28113221-28113222(-) m6A CDS//exon       24284625//27773535 chr16:28113257-28113258(-) m6A CDS//exon       24284625//27773535 chr16:28123271-28123272(-) m6A 3'UTR//CDS//intron       22575960 chr16:28143707-28143708(-) m6A CDS//exon       27371828 chr16:28146550-28146551(-) m6A CDS//exon       24981863//27371828//22575960 chr16:28146607-28146608(-) Y CDS//exon       26075521 chr16:28164178-28164179(-) m6A exon//intron       27773535//22608085 chr16:28167273-28167274(-) m6A exon//intron       24284625//24981863//22608085 chr16:28167473-28167474(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr16:28167523-28167524(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr16:28167537-28167538(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr16:28167598-28167599(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr16:28167804-28167805(-) m6A CDS//exon       27773535 chr16:28192341-28192342(-) m1A 5'UTR//CDS//intron       26863410 chr16:28222723-28222724(-) m6A 5'UTR       - chr16:28222756-28222757(-) m6A 5'UTR       - chr16:28222768-28222769(-) m6A 5'UTR       - chr16:28222787-28222788(-) m6A 5'UTR       - chr16:28222951-28222952(-) Y 5'UTR       26075521 chr16:28223158-28223159(-) m6A 5'UTR       25456834//24981863//27371828//27773536//22575960

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	XPO6	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: XPO6

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.