Detail Information

Basic Information:


  VIRBase ID:  

VHID00509297

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           ARL6IP1:      

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Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p ARL6IP1
miRBase
Accession/Entrez ID		 MIMAT0001581 23204
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - AIP1//ARL6IP//ARMER//SPG61

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ARL6IP1
chr16:18810528(-) A-I      intronic
chr16:18805412(-) A-I      intronic
chr16:18811347(-) A-I      intronic
chr16:18810571(-) A-I      intronic
chr16:18811344(-) A-I      intronic
chr16:18806488(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ARL6IP1
chr16:18803028-18803029(-) Y 3'UTR       25219674
chr16:18803373-18803374(-) m6A 3'UTR       26404942
chr16:18804355-18804356(-) m6A 3'UTR       22575960
chr16:18804433-18804434(-) m6A 3'UTR       22575960
chr16:18810129-18810130(-) m6A 5'UTR//CDS//exon       22575960
chr16:18810146-18810147(-) m6A 5'UTR//CDS//exon       22575960
chr16:18812583-18812584(-) m6A 5'UTR//intron       22575960
chr16:18812804-18812805(-) m6A 5'UTR//exon       22575960
chr16:18812836-18812837(-) m6A 5'UTR//exon       22575960

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate ARL6IP1
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|K562 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: ARL6IP1

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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