Basic Information:

  VIRBase ID:  

VHID00509201

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          SWAP70:  NM_001297714     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	SWAP70
miRBase Accession/Entrez ID	MIMAT0001581	23075
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	HSPC321//SWAP-70

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SWAP70	chr11:9716720(+) A-I      intronic chr11:9743205(+) A-I      intronic chr11:9743168(+) A-I      intronic chr11:9724203(+) A-I      intronic chr11:9743203(+) A-I      intronic chr11:9743204(+) A-I      intronic chr11:9743212(+) A-I      intronic chr11:9743148(+) A-I      intronic chr11:9721252(+) A-I      intronic chr11:9721250(+) A-I      intronic chr11:9721245(+) A-I      intronic chr11:9721243(+) A-I      intronic chr11:9721173(+) A-I      intronic chr11:9721169(+) A-I      intronic chr11:9721128(+) A-I      intronic chr11:9719092(+) A-I      intronic chr11:9719077(+) A-I      intronic chr11:9719039(+) A-I      intronic chr11:9718969(+) A-I      intronic chr11:9742546(+) A-I      intronic chr11:9718923(+) A-I      intronic chr11:9718503(+) A-I      intronic chr11:9716761(+) A-I      intronic chr11:9696625(+) A-I      intronic chr11:9724126(+) A-I      intronic chr11:9696097(+) A-I      intronic chr11:9716710(+) A-I      intronic chr11:9716626(+) A-I      intronic chr11:9696076(+) A-I      intronic chr11:9716660(+) A-I      intronic chr11:9716616(+) A-I      intronic chr11:9712747(+) A-I      intronic chr11:9766332(+) A-I      intronic chr11:9723061(+) A-I      intronic chr11:9763536(+) A-I      intronic chr11:9712739(+) A-I      intronic chr11:9712704(+) A-I      intronic chr11:9712674(+) A-I      intronic chr11:9712665(+) A-I      intronic chr11:9711972(+) A-I      intronic chr11:9711941(+) A-I      intronic chr11:9711926(+) A-I      intronic chr11:9711857(+) A-I      intronic chr11:9704809(+) A-I      intronic chr11:9732691(+) A-I      intronic chr11:9704783(+) A-I      intronic chr11:9704271(+) A-I      intronic chr11:9696567(+) A-I      intronic chr11:9696498(+) A-I      intronic chr11:9696334(+) A-I      intronic chr11:9696300(+) A-I      intronic chr11:9696146(+) A-I      intronic chr11:9696009(+) A-I      intronic chr11:9696007(+) A-I      intronic chr11:9695991(+) A-I      intronic chr11:9695710(+) A-I      intronic chr11:9695631(+) A-I      intronic chr11:9692562(+) A-I      intronic chr11:9692561(+) A-I      intronic chr11:9692507(+) A-I      intronic chr11:9692499(+) A-I      intronic chr11:9692474(+) A-I      intronic chr11:9692467(+) A-I      intronic chr11:9691528(+) A-I      intronic chr11:9691460(+) A-I      intronic chr11:9691436(+) A-I      intronic chr11:9691039(+) A-I      intronic chr11:9690977(+) A-I      intronic chr11:9749052(+) A-I      intronic chr11:9747033(+) A-I      intronic chr11:9690876(+) A-I      intronic chr11:9690814(+) A-I      intronic chr11:9747302(+) A-I      intronic chr11:9687819(+) A-I      intronic chr11:9687758(+) A-I      intronic chr11:9719104(+) A-I      intronic chr11:9694110(+) A-I      intronic chr11:9704673(+) A-I      intronic chr11:9704786(+) A-I      intronic chr11:9718531(+) A-I      intronic chr11:9747027(+) A-I      intronic chr11:9721201(+) A-I      intronic chr11:9734057(+) A-I      intronic chr11:9765649(+) A-I      intronic chr11:9734026(+) A-I      intronic chr11:9721130(+) A-I      intronic chr11:9766200(+) A-I      intronic chr11:9721289(+) A-I      intronic chr11:9764064(+) A-I      intronic chr11:9764050(+) A-I      intronic chr11:9764049(+) A-I      intronic chr11:9763904(+) A-I      intronic chr11:9759349(+) A-I      intronic chr11:9759345(+) A-I      intronic chr11:9759292(+) A-I      intronic chr11:9759267(+) A-I      intronic chr11:9770923(+) A-I      intronic chr11:9766406(+) A-I      intronic chr11:9766371(+) A-I      intronic chr11:9759262(+) A-I      intronic chr11:9759257(+) A-I      intronic chr11:9691413(+) A-I      intronic chr11:9766335(+) A-I      intronic chr11:9759234(+) A-I      intronic chr11:9766308(+) A-I      intronic chr11:9766299(+) A-I      intronic chr11:9766296(+) A-I      intronic chr11:9766294(+) A-I      intronic chr11:9747393(+) A-I      intronic chr11:9766293(+) A-I      intronic chr11:9747391(+) A-I      intronic chr11:9766290(+) A-I      intronic chr11:9746975(+) A-I      intronic chr11:9766279(+) A-I      intronic chr11:9741016(+) A-I      intronic chr11:9740702(+) A-I      intronic chr11:9722818(+) A-I      intronic chr11:9740697(+) A-I      intronic chr11:9740482(+) A-I      intronic chr11:9734076(+) A-I      intronic chr11:9734059(+) A-I      intronic chr11:9766208(+) A-I      intronic chr11:9740536(+) A-I      intronic chr11:9766205(+) A-I      intronic chr11:9734040(+) A-I      intronic chr11:9765716(+) A-I      intronic chr11:9734018(+) A-I      intronic chr11:9704933(+) A-I      intronic chr11:9726140(+) A-I      intronic chr11:9726021(+) A-I      intronic chr11:9765708(+) A-I      intronic chr11:9726006(+) A-I      intronic chr11:9726005(+) A-I      intronic chr11:9765694(+) A-I      intronic chr11:9724110(+) A-I      intronic chr11:9724059(+) A-I      intronic chr11:9704731(+) A-I      intronic chr11:9765675(+) A-I      intronic chr11:9740516(+) A-I      intronic chr11:9724018(+) A-I      intronic chr11:9722982(+) A-I      intronic chr11:9722953(+) A-I      intronic chr11:9721342(+) A-I      intronic chr11:9721282(+) A-I      intronic chr11:9765651(+) A-I      intronic chr11:9721272(+) A-I      intronic chr11:9716655(+) A-I      intronic chr11:9721256(+) A-I      intronic chr11:9771773(+) A-I      3'UTR chr11:9771732(+) A-I      3'UTR chr11:9771698(+) A-I      3'UTR chr11:9771816(+) A-I      3'UTR chr11:9771767(+) A-I      3'UTR chr11:9771768(+) A-I      3'UTR chr11:9771843(+) A-I      3'UTR chr11:9771890(+) A-I      3'UTR chr11:9740398(+) A-I      intronic chr11:9693962(+) A-I      intronic chr11:9724230(+) A-I      intronic chr11:9712005(+) A-I      intronic chr11:9740586(+) A-I      intronic chr11:9766438(+) A-I      intronic chr11:9747356(+) A-I      intronic chr11:9763984(+) A-I      intronic chr11:9691473(+) A-I      intronic chr11:9694142(+) A-I      intronic chr11:9704973(+) A-I      intronic chr11:9696395(+) A-I      intronic chr11:9712630(+) A-I      intronic chr11:9742463(+) A-I      intronic chr11:9748680(+) A-I      intronic chr11:9718959(+) A-I      intronic chr11:9721147(+) A-I      intronic chr11:9722819(+) A-I      intronic chr11:9721251(+) A-I      intronic chr11:9734063(+) A-I      intronic chr11:9740952(+) A-I      intronic chr11:9740775(+) A-I      intronic chr11:9696082(+) A-I      intronic chr11:9740399(+) A-I      intronic chr11:9704814(+) A-I      intronic chr11:9726123(+) A-I      intronic chr11:9740877(+) A-I      intronic chr11:9719064(+) A-I      intronic chr11:9691514(+) A-I      intronic chr11:9704692(+) A-I      intronic chr11:9763541(+) A-I      intronic chr11:9724061(+) A-I      intronic chr11:9691515(+) A-I      intronic chr11:9717491(+) A-I      intronic chr11:9732509(+) A-I      intronic chr11:9704883(+) A-I      intronic chr11:9719347(+) A-I      intronic chr11:9721253(+) A-I      intronic chr11:9748749(+) A-I      intronic chr11:9722813(+) A-I      intronic chr11:9717443(+) A-I      intronic chr11:9687726(+) A-I      intronic chr11:9691554(+) A-I      intronic chr11:9731256(+) A-I      intronic chr11:9695503(+) A-I      intronic chr11:9724477(+) A-I      intronic chr11:9734013(+) A-I      intronic chr11:9724058(+) A-I      intronic chr11:9704404(+) A-I      intronic chr11:9748814(+) A-I      intronic chr11:9732669(+) A-I      intronic chr11:9740926(+) A-I      intronic chr11:9690879(+) A-I      intronic chr11:9688494(+) A-I      intronic chr11:9734025(+) A-I      intronic chr11:9724516(+) A-I      intronic chr11:9732703(+) A-I      intronic chr11:9696369(+) A-I      intronic chr11:9734031(+) A-I      intronic chr11:9695628(+) A-I      intronic chr11:9740690(+) A-I      intronic chr11:9732697(+) A-I      intronic chr11:9695473(+) A-I      intronic chr11:9691544(+) A-I      intronic chr11:9712604(+) A-I      intronic chr11:9691524(+) A-I      intronic chr11:9734080(+) A-I      intronic chr11:9721220(+) A-I      intronic chr11:9747258(+) A-I      intronic chr11:9763983(+) A-I      intronic chr11:9747348(+) A-I      intronic chr11:9726120(+) A-I      intronic chr11:9704798(+) A-I      intronic chr11:9718506(+) A-I      intronic chr11:9696468(+) A-I      intronic chr11:9759189(+) A-I      intronic chr11:9704888(+) A-I      intronic chr11:9719465(+) A-I      intronic chr11:9734506(+) A-I      intronic chr11:9716721(+) A-I      intronic chr11:9704446(+) A-I      intronic chr11:9712545(+) A-I      intronic chr11:9742543(+) A-I      intronic chr11:9766344(+) A-I      intronic chr11:9740497(+) A-I      intronic chr11:9696612(+) A-I      intronic chr11:9704365(+) A-I      intronic chr11:9696018(+) A-I      intronic chr11:9704324(+) A-I      intronic chr11:9704411(+) A-I      intronic chr11:9712606(+) A-I      intronic chr11:9740825(+) A-I      intronic chr11:9695657(+) A-I      intronic chr11:9718934(+) A-I      intronic chr11:9691580(+) A-I      intronic chr11:9696100(+) A-I      intronic chr11:9712004(+) A-I      intronic chr11:9696106(+) A-I      intronic chr11:9716762(+) A-I      intronic chr11:9721249(+) A-I      intronic chr11:9695559(+) A-I      intronic chr11:9764067(+) A-I      intronic chr11:9716665(+) A-I      intronic chr11:9718577(+) A-I      intronic chr11:9747299(+) A-I      intronic chr11:9691499(+) A-I      intronic chr11:9771777(+) A-I      3'UTR chr11:9771709(+) A-I      3'UTR chr11:9771699(+) A-I      3'UTR chr11:9771741(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SWAP70	chr11:9720731(+) A-I intron -    21960545 chr11:9724058(+) A-I intron -    21960545 chr11:9724059(+) A-I intron -    21960545 chr11:9724477(+) A-G intron -    22484847 chr11:9724516(+) A-G intron -    22484847 chr11:9734080(+) A-G intron -    22484847 chr11:9696100(+) A-G intron -    22484847 chr11:9718531(+) A-G intron -    22484847 chr11:9740536(+) A-G intron -    22484847 chr11:9763536(+) A-G intron -    22484847 chr11:9763983(+) A-G intron -    22484847 chr11:9763984(+) A-G intron -    22484847 chr11:9771698(+) A-G intron -    22484847 chr11:9771732(+) A-G intron -    22484847 chr11:9771767(+) A-G intron -    22484847 chr11:9771768(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SWAP70	chr11:9746260-9746261(+) m6A 3'UTR//CDS//exon       22608085 chr11:9746269-9746270(+) m6A 3'UTR//CDS//exon       24981863//26404942//22608085 chr11:9746320-9746321(+) m6A 3'UTR//CDS//exon       24981863//26404942//22608085 chr11:9746344-9746345(+) m6A 3'UTR//CDS//exon       24981863//26404942//27773535//22608085 chr11:9746364-9746365(+) m6A 3'UTR//CDS//exon       24981863//26404942//27773535//22608085 chr11:9746372-9746373(+) m6A 3'UTR//CDS//exon       24981863//26404942//27773535//22608085 chr11:9746407-9746408(+) m6A 3'UTR//CDS//exon       24981863//26404942//27773535//22608085 chr11:9754151-9754152(+) m6A 3'UTR//CDS//exon       24981863 chr11:9754175-9754176(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863 chr11:9754184-9754185(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863 chr11:9754205-9754206(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863 chr11:9759761-9759762(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863 chr11:9759813-9759814(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863 chr11:9759824-9759825(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863 chr11:9761732-9761733(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863 chr11:9761747-9761748(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863 chr11:9761771-9761772(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863 chr11:9761777-9761778(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863 chr11:9761809-9761810(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863 chr11:9761849-9761850(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863 chr11:9761871-9761872(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863 chr11:9761913-9761914(+) m6A exon//intron       24284625//24209618//24981863 chr11:9762039-9762040(+) m6A exon//intron       25456834//24981863 chr11:9762048-9762049(+) m6A exon//intron       25456834//24981863 chr11:9762093-9762094(+) m6A exon//intron       25456834 chr11:9763436-9763437(+) m6A exon//intron       - chr11:9763474-9763475(+) m6A exon//intron       24209618//24981863 chr11:9769437-9769438(+) m6A CDS//intron       24209618//24981863//22575960 chr11:9769477-9769478(+) m6A CDS//intron       24284625//24209618//24981863//22575960 chr11:9769527-9769528(+) m6A CDS//intron       24284625//24209618//24981863//22575960 chr11:9769571-9769572(+) Tm CDS//intron       - chr11:9770669-9770670(+) m6A CDS//intron       24284625//24209618//24981863//27773535 chr11:9770685-9770686(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085 chr11:9770725-9770726(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085 chr11:9771419-9771420(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085 chr11:9771444-9771445(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22608085 chr11:9771468-9771469(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22608085 chr11:9771488-9771489(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:9771505-9771506(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:9771582-9771583(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:9771591-9771592(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:9771708-9771709(+) m6A 3'UTR//intron       24981863 chr11:9771877-9771878(+) m6A 3'UTR       24284625//24981863 chr11:9771890-9771891(+) m6A 3'UTR       24284625//24981863 chr11:9771895-9771896(+) m6A 3'UTR       24284625//24981863 chr11:9771900-9771901(+) m6A 3'UTR       24284625//24981863 chr11:9771905-9771906(+) m6A 3'UTR       24284625//24981863 chr11:9771910-9771911(+) m6A 3'UTR       24284625//24981863 chr11:9771918-9771919(+) m6A 3'UTR       24284625//24981863 chr11:9772209-9772210(+) m6A 3'UTR       24981863 chr11:9772268-9772269(+) m6A 3'UTR       24981863 chr11:9772999-9773000(+) m6A 3'UTR       26404942 chr11:9773857-9773858(+) m6A 3'UTR       24284625 chr11:9773894-9773895(+) m6A 3'UTR       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	SWAP70	Cytosol HCC cell line (HepG2)|HeLa-S3 cells     - Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: SWAP70

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.