Basic Information:

  VIRBase ID:  

VHID00509154

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          STK38L:  NM_015000     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	STK38L
miRBase Accession/Entrez ID	MIMAT0001581	23012
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	NDR2

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	STK38L	chr12:27465011(+) A-I      intronic chr12:27464952(+) A-I      intronic chr12:27464913(+) A-I      intronic chr12:27428410(+) A-I      intronic chr12:27467187(+) A-I      intronic chr12:27467223(+) A-I      intronic chr12:27466501(+) A-I      intronic chr12:27467245(+) A-I      intronic chr12:27467255(+) A-I      intronic chr12:27424813(+) A-I      intronic chr12:27426941(+) A-I      intronic chr12:27465965(+) A-I      intronic chr12:27427065(+) A-I      intronic chr12:27428346(+) A-I      intronic chr12:27428377(+) A-I      intronic chr12:27428396(+) A-I      intronic chr12:27454317(+) A-I      intronic chr12:27454318(+) A-I      intronic chr12:27454321(+) A-I      intronic chr12:27427059(+) A-I      intronic chr12:27454322(+) A-I      intronic chr12:27454394(+) A-I      intronic chr12:27454400(+) A-I      intronic chr12:27454405(+) A-I      intronic chr12:27454454(+) A-I      intronic chr12:27455734(+) A-I      intronic chr12:27455784(+) A-I      intronic chr12:27455803(+) A-I      intronic chr12:27455839(+) A-I      intronic chr12:27456931(+) A-I      intronic chr12:27456993(+) A-I      intronic chr12:27465927(+) A-I      intronic chr12:27466030(+) A-I      intronic chr12:27466536(+) A-I      intronic chr12:27466551(+) A-I      intronic chr12:27467079(+) A-I      intronic chr12:27467105(+) A-I      intronic chr12:27467109(+) A-I      intronic chr12:27467120(+) A-I      intronic chr12:27467148(+) A-I      intronic chr12:27415985(+) A-I      intronic chr12:27415534(+) A-I      intronic chr12:27467299(+) A-I      intronic chr12:27467305(+) A-I      intronic chr12:27415540(+) A-I      intronic chr12:27415571(+) A-I      intronic chr12:27415633(+) A-I      intronic chr12:27415763(+) A-I      intronic chr12:27415871(+) A-I      intronic chr12:27415958(+) A-I      intronic chr12:27466389(+) A-I      intronic chr12:27422715(+) A-I      intronic chr12:27422845(+) A-I      intronic chr12:27422856(+) A-I      intronic chr12:27423540(+) A-I      intronic chr12:27424694(+) A-I      intronic chr12:27424762(+) A-I      intronic chr12:27424772(+) A-I      intronic chr12:27465997(+) A-I      intronic chr12:27428453(+) A-I      intronic chr12:27466392(+) A-I      intronic chr12:27440132(+) A-I      intronic chr12:27441067(+) A-I      intronic chr12:27466358(+) A-I      intronic chr12:27457107(+) A-I      intronic chr12:27459861(+) A-I      intronic chr12:27447203(+) A-I      intronic chr12:27415831(+) A-I      intronic chr12:27466018(+) A-I      intronic chr12:27466060(+) A-I      intronic chr12:27415836(+) A-I      intronic chr12:27451200(+) A-I      intronic chr12:27415511(+) A-I      intronic chr12:27440998(+) A-I      intronic chr12:27466464(+) A-I      intronic chr12:27447768(+) A-I      intronic chr12:27455685(+) A-I      intronic chr12:27447773(+) A-I      intronic chr12:27457013(+) A-I      intronic chr12:27428456(+) A-I      intronic chr12:27454331(+) A-I      intronic chr12:27415817(+) A-I      intronic chr12:27466590(+) A-I      intronic chr12:27457007(+) A-I      intronic chr12:27466454(+) A-I      intronic chr12:27451265(+) A-I      intronic chr12:27451133(+) A-I      intronic chr12:27447901(+) A-I      intronic chr12:27466499(+) A-I      intronic chr12:27415531(+) A-I      intronic chr12:27467133(+) A-I      intronic chr12:27415587(+) A-I      intronic chr12:27447365(+) A-I      intronic chr12:27466481(+) A-I      intronic chr12:27451261(+) A-I      intronic chr12:27465918(+) A-I      intronic chr12:27466513(+) A-I      intronic chr12:27473261(+) A-I      intronic chr12:27467213(+) A-I      intronic chr12:27424822(+) A-I      intronic chr12:27420300(+) A-I      intronic chr12:27428452(+) A-I      intronic chr12:27415783(+) A-I      intronic chr12:27459864(+) A-I      intronic chr12:27422797(+) A-I      intronic chr12:27466027(+) A-I      intronic chr12:27415832(+) A-I      intronic chr12:27466480(+) A-I      intronic chr12:27403785(+) A-I      intronic chr12:27447710(+) A-I      intronic chr12:27464877(+) A-I      intronic chr12:27456933(+) A-I      intronic chr12:27457112(+) A-I      intronic chr12:27466588(+) A-I      intronic chr12:27466021(+) A-I      intronic chr12:27454461(+) A-I      intronic chr12:27428381(+) A-I      intronic chr12:27415563(+) A-I      intronic chr12:27447877(+) A-I      intronic chr12:27428546(+) A-I      intronic chr12:27457017(+) A-I      intronic chr12:27467259(+) A-I      intronic chr12:27464997(+) A-I      intronic chr12:27467244(+) A-I      intronic chr12:27415553(+) A-I      intronic chr12:27459774(+) A-I      intronic chr12:27466319(+) A-I      intronic chr12:27467275(+) A-I      intronic chr12:27415782(+) A-I      intronic chr12:27447191(+) A-I      intronic chr12:27467100(+) A-I      intronic chr12:27424816(+) A-I      intronic chr12:27451146(+) A-I      intronic chr12:27466568(+) A-I      intronic chr12:27451225(+) A-I      intronic chr12:27466444(+) A-I      intronic chr12:27466070(+) A-I      intronic chr12:27459697(+) A-I      intronic chr12:27466456(+) A-I      intronic chr12:27451330(+) A-I      intronic chr12:27415495(+) A-I      intronic chr12:27447180(+) A-I      intronic chr12:27466126(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	STK38L	chr12:27451133(+) A-I intron -    15258596 chr12:27451146(+) A-I intron -    15258596 chr12:27451200(+) A-I intron -    15258596 chr12:27476394(+) T-G intron -    21725310 chr12:27478128(+) A-C intron -    21725310 chr12:27415563(+) A-G intron -    22484847 chr12:27466027(+) A-G intron -    22484847 chr12:27466060(+) A-G intron -    22484847 chr12:27466126(+) A-G intron -    22484847 chr12:27466358(+) A-G intron -    22484847 chr12:27466454(+) A-G intron -    22484847 chr12:27467259(+) A-G intron -    22484847 chr12:27467275(+) A-G intron -    22484847 chr12:27400768(+) G-T intron -    22484847 chr12:27403785(+) A-G intron -    22484847 chr12:27403950(+) G-A intron -    22484847 chr12:27415495(+) A-G intron -    22484847 chr12:27415511(+) A-G intron -    22484847 chr12:27415531(+) A-G intron -    22484847 chr12:27415553(+) A-G intron -    22484847 chr12:27415587(+) A-G intron -    22484847 chr12:27415783(+) A-G intron -    22484847 chr12:27415817(+) A-G intron -    22484847 chr12:27415831(+) A-G intron -    22484847 chr12:27415832(+) A-G intron -    22484847 chr12:27415877(+) G-A intron -    22484847 chr12:27422797(+) A-G intron -    22484847 chr12:27424816(+) A-G intron -    22484847 chr12:27424822(+) A-G intron -    22484847 chr12:27426943(+) C-T intron -    22484847 chr12:27428452(+) A-G intron -    22484847 chr12:27428453(+) A-G intron -    22484847 chr12:27428456(+) A-G intron -    22484847 chr12:27447174(+) T-C intron -    22484847 chr12:27447180(+) A-G intron -    22484847 chr12:27447203(+) A-G intron -    22484847 chr12:27447365(+) A-G intron -    22484847 chr12:27447901(+) A-G intron -    22484847 chr12:27451225(+) A-G intron -    22484847 chr12:27451265(+) A-G intron -    22484847 chr12:27454331(+) A-G intron -    22484847 chr12:27454461(+) A-G intron -    22484847 chr12:27459692(+) T-A intron -    22484847 chr12:27464877(+) A-G intron -    22484847 chr12:27464997(+) A-G intron -    22484847 chr12:27465918(+) A-G intron -    22484847 chr12:27465992(+) T-C intron -    22484847 chr12:27465997(+) A-G intron -    22484847 chr12:27466018(+) A-G intron -    22484847 chr12:27466021(+) A-G intron -    22484847 chr12:27466070(+) A-G intron -    22484847 chr12:27466392(+) A-G intron -    22484847 chr12:27466456(+) A-G intron -    22484847 chr12:27466464(+) A-G intron -    22484847 chr12:27466481(+) A-G intron -    22484847 chr12:27466499(+) A-G intron -    22484847 chr12:27466513(+) A-G intron -    22484847 chr12:27466568(+) A-G intron -    22484847 chr12:27467244(+) A-G intron -    22484847 chr12:27467353(+) G-A intron -    22484847 chr12:27471752(+) G-A intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	STK38L	chr12:27450782-27450783(+) m6A CDS//exon       24981863 chr12:27450808-27450809(+) m6A exon//intron       24981863 chr12:27450853-27450854(+) m6A exon//intron       24981863 chr12:27461307-27461308(+) m6A 3'UTR//CDS//intron       24981863 chr12:27461331-27461332(+) m6A 3'UTR//CDS//intron       24981863 chr12:27461336-27461337(+) m6A 3'UTR//CDS//intron       24981863 chr12:27470286-27470287(+) m6A 3'UTR//CDS       24981863 chr12:27470322-27470323(+) m6A 3'UTR//CDS       24981863 chr12:27470939-27470940(+) m6A 3'UTR//CDS//exon       24981863 chr12:27472280-27472281(+) m6A 3'UTR//CDS//exon       24981863 chr12:27475276-27475277(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22608085 chr12:27475281-27475282(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22608085 chr12:27475296-27475297(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22608085 chr12:27475419-27475420(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22608085 chr12:27475538-27475539(+) m6A 3'UTR//exon       24284625//24209618//24981863//22608085 chr12:27475637-27475638(+) m6A 3'UTR       24284625//24981863//22608085 chr12:27475712-27475713(+) m6A 3'UTR       24284625//24981863//22608085 chr12:27475742-27475743(+) m6A 3'UTR       24284625//24981863//22608085 chr12:27476030-27476031(+) m6A 3'UTR       27773535 chr12:27476550-27476551(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	STK38L	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleoplasm K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: STK38L

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.