Detail Information

Basic Information:


  VIRBase ID:  

VHID00509121

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           SHANK2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p SHANK2
miRBase
Accession/Entrez ID		 MIMAT0001581 22941
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - AUTS17//CORTBP1//CTTNBP1//ProSAP1//SHANK//SPANK-3

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR SHANK2
chr11:70840643(-) A-I      intronic
chr11:70436184(-) A-I      intronic
chr11:70902134(-) A-I      intronic
chr11:70788240(-) A-I      intronic
chr11:70460664(-) A-I      intronic
chr11:70640844(-) A-I      intronic
chr11:70653852(-) A-I      intronic
chr11:70621395(-) A-I      intronic
chr11:70530570(-) A-I      intronic
chr11:70499985(-) A-I      intronic
chr11:70499907(-) A-I      intronic
chr11:70498864(-) A-I      intronic
chr11:70498807(-) A-I      intronic
chr11:70498667(-) A-I      intronic
chr11:70487339(-) A-I      intronic
chr11:70487333(-) A-I      intronic
chr11:70628381(-) A-I      intronic
chr11:70438119(-) A-I      intronic
chr11:70437374(-) A-I      intronic
chr11:70437357(-) A-I      intronic
chr11:70437190(-) A-I      intronic
chr11:70436069(-) A-I      intronic
chr11:70402599(-) A-I      intronic
chr11:70436046(-) A-I      intronic
chr11:70436045(-) A-I      intronic
chr11:70436014(-) A-I      intronic
chr11:70436002(-) A-I      intronic
chr11:70435151(-) A-I      intronic
chr11:70617226(-) A-I      intronic
chr11:70435127(-) A-I      intronic
chr11:70654633(-) A-I      intronic
chr11:70889850(-) A-I      intronic
chr11:70487231(-) A-I      intronic
chr11:70435038(-) A-I      intronic
chr11:70435023(-) A-I      intronic
chr11:70907143(-) A-I      intronic
chr11:70435020(-) A-I      intronic
chr11:70433970(-) A-I      intronic
chr11:70433964(-) A-I      intronic
chr11:70433956(-) A-I      intronic
chr11:70433954(-) A-I      intronic
chr11:70433925(-) A-I      intronic
chr11:70433912(-) A-I      intronic
chr11:70433907(-) A-I      intronic
chr11:70433902(-) A-I      intronic
chr11:70402618(-) A-I      intronic
chr11:70433901(-) A-I      intronic
chr11:70402610(-) A-I      intronic
chr11:70641738(-) A-I      intronic
chr11:70435031(-) A-I      intronic
chr11:70403065(-) A-I      intronic
chr11:70401825(-) A-I      intronic
chr11:70618526(-) A-I      intronic
chr11:70930816(-) A-I      intronic
chr11:70928199(-) A-I      intronic
chr11:70928196(-) A-I      intronic
chr11:70928060(-) A-I      intronic
chr11:70907399(-) A-I      intronic
chr11:70907362(-) A-I      intronic
chr11:70786425(-) A-I      intronic
chr11:70786424(-) A-I      intronic
chr11:70764857(-) A-I      intronic
chr11:70764749(-) A-I      intronic
chr11:70764743(-) A-I      intronic
chr11:70641790(-) A-I      intronic
chr11:70641667(-) A-I      intronic
chr11:70640934(-) A-I      intronic
chr11:70640933(-) A-I      intronic
chr11:70401633(-) A-I      intronic
chr11:70640831(-) A-I      intronic
chr11:70640830(-) A-I      intronic
chr11:70640829(-) A-I      intronic
chr11:70640818(-) A-I      intronic
chr11:70640731(-) A-I      intronic
chr11:70640730(-) A-I      intronic
chr11:70640723(-) A-I      intronic
chr11:70640303(-) A-I      intronic
chr11:70640246(-) A-I      intronic
chr11:70640220(-) A-I      intronic
chr11:70621525(-) A-I      intronic
chr11:70621406(-) A-I      intronic
chr11:70393530(-) A-I      intronic
chr11:70620657(-) A-I      intronic
chr11:70361251(-) A-I      intronic
chr11:70361230(-) A-I      intronic
chr11:70620652(-) A-I      intronic
chr11:70621349(-) A-I      intronic
chr11:70361203(-) A-I      intronic
chr11:70620623(-) A-I      intronic
chr11:70618362(-) A-I      intronic
chr11:70617076(-) A-I      intronic
chr11:70618488(-) A-I      intronic
chr11:70575534(-) A-I      intronic
chr11:70617077(-) A-I      intronic
chr11:70617127(-) A-I      intronic
chr11:70928174(-) A-I      intronic
chr11:70918364(-) A-I      intronic
chr11:70754068(-) A-I      intronic
chr11:70885817(-) A-I      intronic
chr11:70840563(-) A-I      intronic
chr11:70620581(-) A-I      intronic
chr11:70692466(-) A-I      intronic
chr11:70840656(-) A-I      intronic
chr11:70753989(-) A-I      intronic
chr11:70754084(-) A-I      intronic
chr11:70641753(-) A-I      intronic
chr11:70839888(-) A-I      intronic
chr11:70753971(-) A-I      intronic
chr11:70663937(-) A-I      intronic
chr11:70753985(-) A-I      intronic
chr11:70840572(-) A-I      intronic
chr11:70641680(-) A-I      intronic
chr11:70640800(-) A-I      intronic
chr11:70617102(-) A-I      intronic
chr11:70640791(-) A-I      intronic
chr11:70929383(-) A-I      intronic
chr11:70620600(-) A-I      intronic
chr11:70598306(-) A-I      intronic
chr11:70640264(-) A-I      intronic
chr11:70547679(-) A-I      intronic
chr11:70617154(-) A-I      intronic
chr11:70643681(-) A-I      intronic
chr11:70530582(-) A-I      intronic
chr11:70617230(-) A-I      intronic
chr11:70864836(-) A-I      intronic
chr11:70617097(-) A-I      intronic
chr11:70907429(-) A-I      intronic
chr11:70754049(-) A-I      intronic
chr11:70918401(-) A-I      intronic
chr11:70839868(-) A-I      intronic
chr11:70736847(-) A-I      intronic
chr11:70618433(-) A-I      intronic
chr11:70529956(-) A-I      intronic
chr11:70929438(-) A-I      intronic
chr11:70931121(-) A-I      intronic
chr11:70918366(-) A-I      intronic
chr11:70753950(-) A-I      intronic
chr11:70617194(-) A-I      intronic
chr11:70618429(-) A-I      intronic
chr11:70837838(-) A-I      intronic
chr11:70640342(-) A-I      intronic
chr11:70617274(-) A-I      intronic
chr11:70617178(-) A-I      intronic
chr11:70641649(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED SHANK2
chr11:70617097(-) A-I intron -    15342557
chr11:70617102(-) A-I intron -    15342557
chr11:70617154(-) A-I intron -    15342557
chr11:70617178(-) A-I intron -    15342557
chr11:70617194(-) A-I intron -    15342557
chr11:70617226(-) A-I intron -    15342557
chr11:70617230(-) A-I intron -    15342557
chr11:70617274(-) A-I intron -    15342557
chr11:70618429(-) A-I intron -    15342557
chr11:70618433(-) A-I intron -    15342557
chr11:70618488(-) A-I intron -    15342557
chr11:70618526(-) A-I intron -    15342557
chr11:70753950(-) A-I intron -    15342557
chr11:70753971(-) A-I intron -    15342557
chr11:70753985(-) A-I intron -    15342557
chr11:70753989(-) A-I intron -    15342557
chr11:70754084(-) A-I intron -    15342557
chr11:70935766(-) A-I exon 5'UTR    15342557
chr11:70641649(-) A-I intron -    21960545

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SHANK2
chr11:70314008-70314009(-) m6A 3'UTR       27773535
chr11:70314046-70314047(-) m6A 3'UTR       27773535
chr11:70314110-70314111(-) m6A 3'UTR       27773535
chr11:70315647-70315648(-) m6A 3'UTR//exon       27773535
chr11:70315831-70315832(-) m6A 3'UTR//exon       27773535
chr11:70315906-70315907(-) m6A 3'UTR//exon       27773535
chr11:70316974-70316975(-) m6A 3'UTR//exon       27773535
chr11:70316979-70316980(-) m6A 3'UTR//exon       27773535
chr11:70316985-70316986(-) m6A 3'UTR//exon       27773535
chr11:70317035-70317036(-) m6A 3'UTR//exon       27773535
chr11:70317051-70317052(-) m6A 3'UTR//exon       27773535
chr11:70317089-70317090(-) m6A 3'UTR//exon       27773535
chr11:70317699-70317700(-) m6A 3'UTR//exon       27773535
chr11:70317713-70317714(-) m6A 3'UTR//exon       27773535
chr11:70317718-70317719(-) m6A 3'UTR//exon       27773535
chr11:70317740-70317741(-) m6A 3'UTR//exon       27773535
chr11:70318591-70318592(-) m6A 3'UTR//exon       27773535
chr11:70318620-70318621(-) m6A 3'UTR//exon       27773535
chr11:70318751-70318752(-) m6A 3'UTR//exon       25456834//27773535
chr11:70318801-70318802(-) m6A 3'UTR//exon       25456834//24981863//27773535
chr11:70318910-70318911(-) m6A 3'UTR//exon       25456834//24981863//27773535
chr11:70318948-70318949(-) m6A 3'UTR//exon       25456834//24981863//27773535
chr11:70318980-70318981(-) m6A 3'UTR//CDS//exon       25456834//24981863//27773535
chr11:70318991-70318992(-) m6A 3'UTR//CDS//exon       25456834//24981863//27773535
chr11:70319010-70319011(-) m6A 3'UTR//CDS//exon       25456834//24981863//26404942//27773535//22575960
chr11:70319052-70319053(-) m6A 3'UTR//CDS//exon       25456834//24981863//26404942//27773535//22575960//22608085
chr11:70319067-70319068(-) m6A 3'UTR//CDS//exon       25456834//24981863//26404942//27773535//22575960//22608085
chr11:70319097-70319098(-) m6A 3'UTR//CDS//exon       25456834//24981863//26404942//27773535//22608085
chr11:70319117-70319118(-) m6A 3'UTR//CDS//exon       25456834//24981863//26404942//27773535
chr11:70319127-70319128(-) m6A 3'UTR//CDS//exon       25456834//24981863//26404942//27773535
chr11:70319159-70319160(-) m6A 3'UTR//CDS//exon       25456834//24981863//26404942//27773535
chr11:70319164-70319165(-) m6A 3'UTR//CDS//exon       25456834//24981863//26404942//27773535
chr11:70319180-70319181(-) m6A 3'UTR//CDS//exon       25456834//24981863//27773535
chr11:70319256-70319257(-) m6A 3'UTR//CDS//exon       25456834//24981863//27773535
chr11:70319362-70319363(-) m6A 3'UTR//CDS//exon       25456834//24981863//27773535
chr11:70319370-70319371(-) m6A 3'UTR//CDS//exon       25456834//24981863//27773535
chr11:70319413-70319414(-) m6A 3'UTR//CDS//exon       25456834//24981863//27773535
chr11:70319422-70319423(-) m6A 3'UTR//CDS//exon       25456834//24981863//27773535
chr11:70319653-70319654(-) m6A exon//intron       -
chr11:70331462-70331463(-) m6A CDS//intron       25456834//24981863//27773535
chr11:70331493-70331494(-) m6A CDS//intron       25456834//24981863//27773535
chr11:70331514-70331515(-) m6A CDS//intron       24209618//25456834//24981863//27773535
chr11:70331596-70331597(-) m6A CDS//intron       25456834//24981863//27773535
chr11:70331768-70331769(-) m6A CDS//intron       24981863//26404942//27773535
chr11:70331814-70331815(-) m6A CDS//intron       24981863//27773535
chr11:70331913-70331914(-) m6A CDS//intron       27773535
chr11:70331988-70331989(-) m6A CDS//intron       25456834//24981863//27773535
chr11:70332015-70332016(-) m6A CDS//intron       25456834//24981863//27773535
chr11:70332042-70332043(-) m6A CDS//intron       25456834//24981863//27773535
chr11:70332090-70332091(-) m6A CDS//intron       25456834//24981863//27773535
chr11:70332198-70332199(-) m6A CDS//intron       24981863//27773535
chr11:70332277-70332278(-) m6A CDS//intron       24981863//27773535
chr11:70332334-70332335(-) m6A CDS//intron       27773535
chr11:70332372-70332373(-) m6A CDS//intron       27773535
chr11:70332423-70332424(-) m6A CDS//intron       27773535
chr11:70332486-70332487(-) m6A CDS//intron       25456834//27773535
chr11:70332507-70332508(-) m6A CDS//intron       25456834//24981863//27773535
chr11:70332531-70332532(-) m6A CDS//intron       25456834//24981863//27773535
chr11:70332547-70332548(-) m6A CDS//intron       25456834//24981863//27773535
chr11:70332558-70332559(-) m6A CDS//intron       25456834//24981863//27773535
chr11:70332584-70332585(-) m6A CDS//intron       25456834//24981863//27773535
chr11:70332594-70332595(-) m6A CDS//intron       25456834//24981863//27773535
chr11:70332662-70332663(-) m6A CDS//intron       25456834//24981863//27773535
chr11:70332698-70332699(-) m6A CDS//intron       25456834//24981863//27773535
chr11:70332726-70332727(-) m6A CDS//intron       25456834//24981863//27773535
chr11:70332933-70332934(-) m6A CDS//intron       -
chr11:70332990-70332991(-) m6A CDS//intron       25456834
chr11:70333080-70333081(-) m6A CDS//intron       25456834
chr11:70333104-70333105(-) m6A CDS//intron       25456834
chr11:70333335-70333336(-) m6A CDS//intron       27773535
chr11:70333503-70333504(-) m6A CDS//intron       -
chr11:70333512-70333513(-) m6A CDS//intron       24981863
chr11:70333527-70333528(-) m6A CDS//intron       24981863
chr11:70333740-70333741(-) m6A CDS//intron       27773535
chr11:70333752-70333753(-) m6A CDS//intron       27773535
chr11:70514768-70514769(-) m6A 3'UTR//intron       27773535
chr11:70742614-70742615(-) m6A CDS//exon       27773535
chr11:70742625-70742626(-) m6A CDS//exon       27773535
chr11:70805731-70805732(-) m6A 3'UTR//CDS       27773535
chr11:70820992-70820993(-) m6A 3'UTR//CDS       27773535
chr11:70821027-70821028(-) m6A 3'UTR//CDS       27773535
chr11:70858278-70858279(-) m6A CDS       24981863//27773535
chr11:70858295-70858296(-) m6A CDS       24981863//27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate SHANK2
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Insoluble cytoplasm HCC cell line (HepG2)     -
Membrane HCC cell line (HepG2)     -
Nucleus HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: SHANK2

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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