Basic Information:

  VIRBase ID:  

VHID00509073

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          ZHX2:  NM_014943     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	ZHX2
miRBase Accession/Entrez ID	MIMAT0001581	22882
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	AFR1//RAF

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ZHX2	chr8:123932299(+) A-I      intronic chr8:123932285(+) A-I      intronic chr8:123895078(+) A-I      intronic chr8:123895050(+) A-I      intronic chr8:123895030(+) A-I      intronic chr8:123895025(+) A-I      intronic chr8:123892934(+) A-I      intronic chr8:123892914(+) A-I      intronic chr8:123892907(+) A-I      intronic chr8:123892474(+) A-I      intronic chr8:123892473(+) A-I      intronic chr8:123892447(+) A-I      intronic chr8:123892433(+) A-I      intronic chr8:123892410(+) A-I      intronic chr8:123892292(+) A-I      intronic chr8:123892281(+) A-I      intronic chr8:123892265(+) A-I      intronic chr8:123891546(+) A-I      intronic chr8:123891539(+) A-I      intronic chr8:123886703(+) A-I      intronic chr8:123882810(+) A-I      intronic chr8:123932364(+) A-I      intronic chr8:123932391(+) A-I      intronic chr8:123932420(+) A-I      intronic chr8:123932435(+) A-I      intronic chr8:123933351(+) A-I      intronic chr8:123933402(+) A-I      intronic chr8:123933415(+) A-I      intronic chr8:123933426(+) A-I      intronic chr8:123933451(+) A-I      intronic chr8:123933456(+) A-I      intronic chr8:123933524(+) A-I      intronic chr8:123933571(+) A-I      intronic chr8:123933891(+) A-I      intronic chr8:123939557(+) A-I      intronic chr8:123939612(+) A-I      intronic chr8:123939614(+) A-I      intronic chr8:123941649(+) A-I      intronic chr8:123941741(+) A-I      intronic chr8:123942939(+) A-I      intronic chr8:123950805(+) A-I      intronic chr8:123950815(+) A-I      intronic chr8:123951065(+) A-I      intronic chr8:123953250(+) A-I      intronic chr8:123953286(+) A-I      intronic chr8:123953412(+) A-I      intronic chr8:123961495(+) A-I      intronic chr8:123813923(+) A-I      intronic chr8:123880615(+) A-I      intronic chr8:123812226(+) A-I      intronic chr8:123810911(+) A-I      intronic chr8:123803082(+) A-I      intronic chr8:123803030(+) A-I      intronic chr8:123802947(+) A-I      intronic chr8:123900851(+) A-I      intronic chr8:123920633(+) A-I      intronic chr8:123892929(+) A-I      intronic chr8:123953270(+) A-I      intronic chr8:123880613(+) A-I      intronic chr8:123879261(+) A-I      intronic chr8:123877574(+) A-I      intronic chr8:123877552(+) A-I      intronic chr8:123877507(+) A-I      intronic chr8:123877497(+) A-I      intronic chr8:123877387(+) A-I      intronic chr8:123850934(+) A-I      intronic chr8:123840096(+) A-I      intronic chr8:123840095(+) A-I      intronic chr8:123839538(+) A-I      intronic chr8:123839395(+) A-I      intronic chr8:123839380(+) A-I      intronic chr8:123814474(+) A-I      intronic chr8:123862307(+) A-I      intronic chr8:123814432(+) A-I      intronic chr8:123814403(+) A-I      intronic chr8:123813961(+) A-I      intronic chr8:123812357(+) A-I      intronic chr8:123812347(+) A-I      intronic chr8:123812330(+) A-I      intronic chr8:123812254(+) A-I      intronic chr8:123880625(+) A-I      intronic chr8:123880637(+) A-I      intronic chr8:123892924(+) A-I      intronic chr8:123880786(+) A-I      intronic chr8:123880819(+) A-I      intronic chr8:123813931(+) A-I      intronic chr8:123880879(+) A-I      intronic chr8:123880885(+) A-I      intronic chr8:123880910(+) A-I      intronic chr8:123882683(+) A-I      intronic chr8:123932336(+) A-I      intronic chr8:123882686(+) A-I      intronic chr8:123882758(+) A-I      intronic chr8:123882782(+) A-I      intronic chr8:123882790(+) A-I      intronic chr8:123981075(+) A-I      intronic chr8:123980936(+) A-I      intronic chr8:123980929(+) A-I      intronic chr8:123932358(+) A-I      intronic chr8:123891631(+) A-I      intronic chr8:123932312(+) A-I      intronic chr8:123962017(+) A-I      intronic chr8:123961972(+) A-I      intronic chr8:123891579(+) A-I      intronic chr8:123950848(+) A-I      intronic chr8:123813731(+) A-I      intronic chr8:123886584(+) A-I      intronic chr8:123972641(+) A-I      intronic chr8:123823482(+) A-I      intronic chr8:123933803(+) A-I      intronic chr8:123810888(+) A-I      intronic chr8:123892286(+) A-I      intronic chr8:123951017(+) A-I      intronic chr8:123968188(+) A-I      intronic chr8:123840273(+) A-I      intronic chr8:123941704(+) A-I      intronic chr8:123895114(+) A-I      intronic chr8:123895178(+) A-I      intronic chr8:123834172(+) A-I      intronic chr8:123803121(+) A-I      intronic chr8:123814504(+) A-I      intronic chr8:123942992(+) A-I      intronic chr8:123813856(+) A-I      intronic chr8:123933592(+) A-I      intronic chr8:123810830(+) A-I      intronic chr8:123920579(+) A-I      intronic chr8:123882807(+) A-I      intronic chr8:123892324(+) A-I      intronic chr8:123933336(+) A-I      intronic chr8:123972517(+) A-I      intronic chr8:123972631(+) A-I      intronic chr8:123950891(+) A-I      intronic chr8:123949900(+) A-I      intronic chr8:123953288(+) A-I      intronic chr8:123839539(+) A-I      intronic chr8:123840232(+) A-I      intronic chr8:123968214(+) A-I      intronic chr8:123892849(+) A-I      intronic chr8:123882866(+) A-I      intronic chr8:123949839(+) A-I      intronic chr8:123873151(+) A-I      intronic chr8:123950002(+) A-I      intronic chr8:123839385(+) A-I      intronic chr8:123810863(+) A-I      intronic chr8:123892465(+) A-I      intronic chr8:123933461(+) A-I      intronic chr8:123839388(+) A-I      intronic chr8:123941673(+) A-I      intronic chr8:123814380(+) A-I      intronic chr8:123814367(+) A-I      intronic chr8:123886702(+) A-I      intronic chr8:123951087(+) A-I      intronic chr8:123812167(+) A-I      intronic chr8:123932504(+) A-I      intronic chr8:123840151(+) A-I      intronic chr8:123961820(+) A-I      intronic chr8:123892487(+) A-I      intronic chr8:123839463(+) A-I      intronic chr8:123941668(+) A-I      intronic chr8:123962055(+) A-I      intronic chr8:123932403(+) A-I      intronic chr8:123933422(+) A-I      intronic chr8:123892341(+) A-I      intronic chr8:123813832(+) A-I      intronic chr8:123882757(+) A-I      intronic chr8:123966677(+) A-I      intronic chr8:123880629(+) A-I      intronic chr8:123810768(+) A-I      intronic chr8:123950096(+) A-I      intronic chr8:123900861(+) A-I      intronic chr8:123839352(+) A-I      intronic chr8:123900902(+) A-I      intronic chr8:123892772(+) A-I      intronic chr8:123813724(+) A-I      intronic chr8:123920712(+) A-I      intronic chr8:123941835(+) A-I      intronic chr8:123962013(+) A-I      intronic chr8:123839384(+) A-I      intronic chr8:123880662(+) A-I      intronic chr8:123953408(+) A-I      intronic chr8:123813922(+) A-I      intronic chr8:123955459(+) A-I      intronic chr8:123880705(+) A-I      intronic chr8:123814576(+) A-I      intronic chr8:123881104(+) A-I      intronic chr8:123839340(+) A-I      intronic chr8:123891563(+) A-I      intronic chr8:123892939(+) A-I      intronic chr8:123972639(+) A-I      intronic chr8:123882614(+) A-I      intronic chr8:123812133(+) A-I      intronic chr8:123972657(+) A-I      intronic chr8:123981217(+) A-I      intronic chr8:123881667(+) A-I      intronic chr8:123881054(+) A-I      intronic chr8:123839567(+) A-I      intronic chr8:123933463(+) A-I      intronic chr8:123814488(+) A-I      intronic chr8:123895060(+) A-I      intronic chr8:123812363(+) A-I      intronic chr8:123921416(+) A-I      intronic chr8:123813905(+) A-I      intronic chr8:123810823(+) A-I      intronic chr8:123949851(+) A-I      intronic chr8:123882741(+) A-I      intronic chr8:123891629(+) A-I      intronic chr8:123803027(+) A-I      intronic chr8:123840278(+) A-I      intronic chr8:123892785(+) A-I      intronic chr8:123882799(+) A-I      intronic chr8:123810770(+) A-I      intronic chr8:123892329(+) A-I      intronic chr8:123810861(+) A-I      intronic chr8:123834073(+) A-I      intronic chr8:123816631(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ZHX2	chr8:123862253(+) A-G intron -    22484847 chr8:123862310(+) A-G intron -    22484847 chr8:123862343(+) A-G intron -    22484847 chr8:123863387(+) A-G intron -    22484847 chr8:123802916(+) A-G intron -    22484847 chr8:123812133(+) A-G intron -    22484847 chr8:123812363(+) A-G intron -    22484847 chr8:123813731(+) A-G intron -    22484847 chr8:123813905(+) A-G intron -    22484847 chr8:123814367(+) A-G intron -    22484847 chr8:123814380(+) A-G intron -    22484847 chr8:123814407(+) A-G intron -    22484847 chr8:123814488(+) A-G intron -    22484847 chr8:123814504(+) A-G intron -    22484847 chr8:123814576(+) A-G intron -    22484847 chr8:123828211(+) A-T intron -    22484847 chr8:123839384(+) A-G intron -    22484847 chr8:123839385(+) A-G intron -    22484847 chr8:123840079(+) A-G intron -    22484847 chr8:123840102(+) A-G intron -    22484847 chr8:123840242(+) A-G intron -    22484847 chr8:123840249(+) A-G intron -    22484847 chr8:123840278(+) A-G intron -    22484847 chr8:123880629(+) A-G intron -    22484847 chr8:123880662(+) A-G intron -    22484847 chr8:123880793(+) A-G intron -    22484847 chr8:123881054(+) A-G intron -    22484847 chr8:123882741(+) A-G intron -    22484847 chr8:123882757(+) A-G intron -    22484847 chr8:123886702(+) A-G intron -    22484847 chr8:123891563(+) A-G intron -    22484847 chr8:123891579(+) A-G intron -    22484847 chr8:123891629(+) A-G intron -    22484847 chr8:123892231(+) A-G intron -    22484847 chr8:123892286(+) A-G intron -    22484847 chr8:123892324(+) A-G intron -    22484847 chr8:123892465(+) A-G intron -    22484847 chr8:123892487(+) A-G intron -    22484847 chr8:123892772(+) A-G intron -    22484847 chr8:123892785(+) A-G intron -    22484847 chr8:123892789(+) A-G intron -    22484847 chr8:123892804(+) A-G intron -    22484847 chr8:123892845(+) T-C intron -    22484847 chr8:123892920(+) A-G intron -    22484847 chr8:123892939(+) A-G intron -    22484847 chr8:123895060(+) A-G intron -    22484847 chr8:123895114(+) A-G intron -    22484847 chr8:123895178(+) A-G intron -    22484847 chr8:123918929(+) G-T intron -    22484847 chr8:123920460(+) A-G intron -    22484847 chr8:123920536(+) T-C intron -    22484847 chr8:123920537(+) T-C intron -    22484847 chr8:123920577(+) T-C intron -    22484847 chr8:123920579(+) A-G intron -    22484847 chr8:123920600(+) T-C intron -    22484847 chr8:123921416(+) A-G intron -    22484847 chr8:123921478(+) T-C intron -    22484847 chr8:123921491(+) T-C intron -    22484847 chr8:123921545(+) T-C intron -    22484847 chr8:123921551(+) T-C intron -    22484847 chr8:123933336(+) A-G intron -    22484847 chr8:123933422(+) A-G intron -    22484847 chr8:123933461(+) A-G intron -    22484847 chr8:123933463(+) A-G intron -    22484847 chr8:123933567(+) A-G intron -    22484847 chr8:123941717(+) T-C intron -    22484847 chr8:123950963(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZHX2	chr8:123875664-123875665(+) m6A 5'UTR//intron       24981863 chr8:123963600-123963601(+) m6A 5'UTR       24981863//22608085 chr8:123963606-123963607(+) m6A 5'UTR       24284625//24981863//27773535//22608085 chr8:123963613-123963614(+) m6A 5'UTR       24284625//24981863//27773535//22608085 chr8:123963741-123963742(+) m6A 5'UTR       24284625//24209618//25456834//24981863//27773535//22608085 chr8:123963792-123963793(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22608085 chr8:123963809-123963810(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr8:123963832-123963833(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr8:123963883-123963884(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr8:123963899-123963900(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr8:123963907-123963908(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr8:123963968-123963969(+) m6A CDS       24284625//25456834//24981863//27773535//22608085 chr8:123964015-123964016(+) m6A CDS       24284625//24981863//22608085 chr8:123964197-123964198(+) m6A CDS       24981863//22608085 chr8:123964208-123964209(+) m6A CDS       24981863//22608085 chr8:123964221-123964222(+) m6A CDS       24981863//22608085 chr8:123964263-123964264(+) m6A CDS       24981863//22608085 chr8:123964299-123964300(+) m6A CDS       25456834//24981863//22608085 chr8:123964322-123964323(+) m6A CDS       25456834//24981863//22575960//22608085 chr8:123964378-123964379(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr8:123964392-123964393(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr8:123964411-123964412(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr8:123964433-123964434(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr8:123964459-123964460(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr8:123964469-123964470(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr8:123964869-123964870(+) m6A CDS       24981863 chr8:123964970-123964971(+) m6A CDS       24284625//24981863 chr8:123965000-123965001(+) m6A CDS       24284625//24981863 chr8:123965088-123965089(+) m6A CDS       24284625//24981863 chr8:123965275-123965276(+) m6A CDS       24981863//22608085 chr8:123965329-123965330(+) m6A CDS       24981863//22608085 chr8:123965358-123965359(+) m6A CDS       25456834//24981863//22608085 chr8:123965386-123965387(+) m6A CDS       25456834//24981863//22608085 chr8:123965423-123965424(+) m6A CDS       25456834//24981863//22608085 chr8:123965445-123965446(+) m6A CDS       25456834//24981863//22608085 chr8:123965503-123965504(+) m6A CDS       25456834//22608085 chr8:123965513-123965514(+) m6A CDS       25456834//22608085 chr8:123965663-123965664(+) m6A CDS       22608085 chr8:123965697-123965698(+) m6A CDS       25456834//24981863//22608085 chr8:123965742-123965743(+) m6A CDS       25456834//24981863//22608085 chr8:123965757-123965758(+) m6A CDS       25456834//24981863//22608085 chr8:123965785-123965786(+) m6A CDS       24284625//25456834//24981863//27773535//22608085 chr8:123965808-123965809(+) m6A CDS       24284625//25456834//24981863//27773535//22608085 chr8:123965891-123965892(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr8:123965947-123965948(+) m6A CDS       24284625//25456834//24981863//27773535//22575960//22608085 chr8:123965971-123965972(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr8:123966022-123966023(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr8:123966058-123966059(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr8:123966212-123966213(+) m6A CDS       24209618//24981863//22608085 chr8:123966226-123966227(+) m6A CDS       24209618//22608085 chr8:123966264-123966265(+) m6A 3'UTR       22608085 chr8:123985495-123985496(+) m6A 3'UTR       - chr8:123985591-123985592(+) m6A 3'UTR       24981863 chr8:123985659-123985660(+) m6A 3'UTR       24981863 chr8:123986562-123986563(+) m6A 3'UTR       24981863 chr8:123986570-123986571(+) m6A 3'UTR       24981863 chr8:123986599-123986600(+) m6A 3'UTR       24981863 chr8:123986683-123986684(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ZHX2	Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleus HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: ZHX2

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.