Basic Information:

  VIRBase ID:  

VHID00508798

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          WWP1:  NM_007013     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	WWP1
miRBase Accession/Entrez ID	MIMAT0001581	11059
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	AIP5//hSDRP1//Tiul1

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	WWP1	chr8:87415586(+) A-I      intronic chr8:87476035(+) A-I      intronic chr8:87399845(+) A-I      intronic chr8:87476050(+) A-I      intronic chr8:87476043(+) A-I      intronic chr8:87394824(+) A-I      intronic chr8:87415573(+) A-I      intronic chr8:87370805(+) A-I      intronic chr8:87394837(+) A-I      intronic chr8:87394839(+) A-I      intronic chr8:87476040(+) A-I      intronic chr8:87477690(+) A-I      intronic chr8:87399987(+) A-I      intronic chr8:87387104(+) A-I      intronic chr8:87414534(+) A-I      intronic chr8:87476028(+) A-I      intronic chr8:87475732(+) A-I      intronic chr8:87475697(+) A-I      intronic chr8:87475685(+) A-I      intronic chr8:87363626(+) A-I      intronic chr8:87363624(+) A-I      intronic chr8:87399982(+) A-I      intronic chr8:87363611(+) A-I      intronic chr8:87387131(+) A-I      intronic chr8:87475653(+) A-I      intronic chr8:87463358(+) A-I      intronic chr8:87463264(+) A-I      intronic chr8:87463263(+) A-I      intronic chr8:87415556(+) A-I      intronic chr8:87463262(+) A-I      intronic chr8:87459535(+) A-I      intronic chr8:87442767(+) A-I      intronic chr8:87387177(+) A-I      intronic chr8:87388669(+) A-I      intronic chr8:87421537(+) A-I      intronic chr8:87421592(+) A-I      intronic chr8:87421602(+) A-I      intronic chr8:87421855(+) A-I      intronic chr8:87394766(+) A-I      intronic chr8:87399975(+) A-I      intronic chr8:87399962(+) A-I      intronic chr8:87399872(+) A-I      intronic chr8:87399854(+) A-I      intronic chr8:87476848(+) A-I      intronic chr8:87406775(+) A-I      intronic chr8:87406758(+) A-I      intronic chr8:87395851(+) A-I      intronic chr8:87476815(+) A-I      intronic chr8:87476163(+) A-I      intronic chr8:87476159(+) A-I      intronic chr8:87476128(+) A-I      intronic chr8:87399926(+) A-I      intronic chr8:87421969(+) A-I      intronic chr8:87442565(+) A-I      intronic chr8:87421970(+) A-I      intronic chr8:87421995(+) A-I      intronic chr8:87476034(+) A-I      intronic chr8:87421947(+) A-I      intronic chr8:87421943(+) A-I      intronic chr8:87421940(+) A-I      intronic chr8:87421939(+) A-I      intronic chr8:87476884(+) A-I      intronic chr8:87476849(+) A-I      intronic chr8:87477702(+) A-I      intronic chr8:87399805(+) A-I      intronic chr8:87395860(+) A-I      intronic chr8:87394877(+) A-I      intronic chr8:87477704(+) A-I      intronic chr8:87394856(+) A-I      intronic chr8:87394787(+) A-I      intronic chr8:87394775(+) A-I      intronic chr8:87409064(+) A-I      intronic chr8:87421543(+) A-I      intronic chr8:87405657(+) A-I      intronic chr8:87442697(+) A-I      intronic chr8:87421516(+) A-I      intronic chr8:87422009(+) A-I      intronic chr8:87463385(+) A-I      intronic chr8:87371006(+) A-I      intronic chr8:87476824(+) A-I      intronic chr8:87376888(+) A-I      intronic chr8:87442639(+) A-I      intronic chr8:87398545(+) A-I      intronic chr8:87463186(+) A-I      intronic chr8:87399871(+) A-I      intronic chr8:87399936(+) A-I      intronic chr8:87399881(+) A-I      intronic chr8:87372024(+) A-I      intronic chr8:87451685(+) A-I      intronic chr8:87476205(+) A-I      intronic chr8:87442596(+) A-I      intronic chr8:87376924(+) A-I      intronic chr8:87475616(+) A-I      intronic chr8:87476928(+) A-I      intronic chr8:87477703(+) A-I      intronic chr8:87476125(+) A-I      intronic chr8:87476277(+) A-I      intronic chr8:87451686(+) A-I      intronic chr8:87451318(+) A-I      intronic chr8:87376885(+) A-I      intronic chr8:87399868(+) A-I      intronic chr8:87442359(+) A-I      intronic chr8:87475636(+) A-I      intronic chr8:87421888(+) A-I      intronic chr8:87399958(+) A-I      intronic chr8:87476179(+) A-I      intronic chr8:87476219(+) A-I      intronic chr8:87365986(+) A-I      intronic chr8:87451689(+) A-I      intronic chr8:87405555(+) A-I      intronic chr8:87475796(+) A-I      intronic chr8:87475665(+) A-I      intronic chr8:87477824(+) A-I      intronic chr8:87477782(+) A-I      intronic chr8:87434047(+) A-I      intronic chr8:87405497(+) A-I      intronic chr8:87399792(+) A-I      intronic chr8:87451608(+) A-I      intronic chr8:87376921(+) A-I      intronic chr8:87476874(+) A-I      intronic chr8:87475735(+) A-I      intronic chr8:87360577(+) A-I      intronic chr8:87476830(+) A-I      intronic chr8:87463386(+) A-I      intronic chr8:87476278(+) A-I      intronic chr8:87475715(+) A-I      intronic chr8:87414615(+) A-I      intronic chr8:87451317(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	WWP1	chr8:87476277(+) A-I intron -    22327324 chr8:87394744(+) A-I intron -    21960545 chr8:87394766(+) A-I intron -    21960545 chr8:87395824(+) A-I intron -    21960545 chr8:87405606(+) A-I intron -    21960545 chr8:87406737(+) A-I intron -    21960545 chr8:87406812(+) A-I intron -    21960545 chr8:87407791(+) A-I intron -    21960545 chr8:87407811(+) A-I intron -    21960545 chr8:87407836(+) A-I intron -    21960545 chr8:87407851(+) A-I intron -    21960545 chr8:87408881(+) A-I intron -    21960545 chr8:87448407(+) A-I intron -    21960545 chr8:87449171(+) A-I intron -    21960545 chr8:87449217(+) A-I intron -    21960545 chr8:87451622(+) A-I intron -    21960545 chr8:87475653(+) A-I intron -    21960545 chr8:87475665(+) A-I intron -    21960545 chr8:87476824(+) A-I intron -    21960545 chr8:87476874(+) A-I intron -    21960545 chr8:87477704(+) A-I intron -    21960545 chr8:87477708(+) A-I intron -    21960545 chr8:87477724(+) A-I intron -    21960545 chr8:87371006(+) A-G intron -    22484847 chr8:87394751(+) A-G intron -    22484847 chr8:87395745(+) C-G intron -    22484847 chr8:87400497(+) C-T intron -    22484847 chr8:87414615(+) A-G intron -    22484847 chr8:87442301(+) A-G intron -    22484847 chr8:87442359(+) A-G intron -    22484847 chr8:87442411(+) T-C intron -    22484847 chr8:87442596(+) A-G intron -    22484847 chr8:87442697(+) A-G intron -    22484847 chr8:87444917(+) A-G intron -    22484847 chr8:87473059(+) G-T intron -    22484847 chr8:87473092(+) G-A intron -    22484847 chr8:87475567(+) A-G intron -    22484847 chr8:87475636(+) A-G intron -    22484847 chr8:87475665(+) A-G intron -    22484847 chr8:87475723(+) T-C intron -    22484847 chr8:87476125(+) A-G intron -    22484847 chr8:87476205(+) A-G intron -    22484847 chr8:87476277(+) A-G intron -    22484847 chr8:87476824(+) A-G intron -    22484847 chr8:87476830(+) A-G intron -    22484847 chr8:87477786(+) T-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	WWP1	chr8:87410586-87410587(+) m6A CDS//exon       24981863 chr8:87410595-87410596(+) m6A CDS//exon       24981863 chr8:87410609-87410610(+) m6A CDS//exon       24981863 chr8:87410629-87410630(+) m6A CDS//exon       24981863 chr8:87410687-87410688(+) m6A CDS//exon       24981863 chr8:87447906-87447907(+) m6A CDS//exon       - chr8:87450827-87450828(+) m6A CDS//exon       - chr8:87479229-87479230(+) m6A 3'UTR//intron       22608085 chr8:87479273-87479274(+) m6A 3'UTR//intron       24981863//27773535//22608085 chr8:87479362-87479363(+) m6A 3'UTR//intron       24981863//22608085 chr8:87479394-87479395(+) m6A 3'UTR//intron       24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	WWP1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: WWP1

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.