Basic Information:

  VIRBase ID:  

VHID00508775

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          LILRB3:  NR_135495     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	LILRB3
miRBase Accession/Entrez ID	MIMAT0001581	11025
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	CD85A//HL9//ILT-5//ILT5//LILRA6//LIR-3//LIR3//PIR-B//PIRB

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	LILRB3	chr19:54720719-54720720(-) m6A 3'UTR       27371828 chr19:54720726-54720727(-) m6A 3'UTR       27371828 chr19:54720760-54720761(-) m6A 3'UTR       27371828 chr19:54720815-54720816(-) m6A 3'UTR       27371828 chr19:54720824-54720825(-) m6A 3'UTR       27371828 chr19:54720844-54720845(-) m6A 3'UTR       27371828 chr19:54720857-54720858(-) m6A 3'UTR       27371828 chr19:54720873-54720874(-) m6A 3'UTR       27371828 chr19:54720883-54720884(-) m6A 3'UTR       27371828 chr19:54720915-54720916(-) m6A 3'UTR       27371828 chr19:54720922-54720923(-) m6A 3'UTR       27371828 chr19:54720944-54720945(-) m6A 3'UTR       27371828 chr19:54721006-54721007(-) m6A 3'UTR//CDS//exon       27371828 chr19:54721194-54721195(-) m6A 3'UTR//CDS//exon       27371828 chr19:54721206-54721207(-) m6A 3'UTR//CDS//exon       27371828 chr19:54721224-54721225(-) m6A 3'UTR//CDS//exon       27371828 chr19:54721233-54721234(-) m6A 3'UTR//CDS//exon       27371828 chr19:54721295-54721296(-) m6A 3'UTR//CDS//exon       27371828 chr19:54721326-54721327(-) m6A 3'UTR//CDS//exon       27371828 chr19:54721372-54721373(-) m6A exon//intron       27371828 chr19:54721380-54721381(-) m6A exon//intron       27371828 chr19:54721415-54721416(-) m6A exon//intron       27371828 chr19:54722236-54722237(-) m6A 3'UTR//CDS//exon       27371828 chr19:54722251-54722252(-) m6A 3'UTR//CDS//exon       27371828 chr19:54722266-54722267(-) m6A 3'UTR//CDS//exon       27371828 chr19:54722473-54722474(-) m6A exon//intron       27371828 chr19:54722494-54722495(-) m6A exon//intron       27371828 chr19:54722518-54722519(-) m6A 3'UTR//CDS//exon       27371828 chr19:54722649-54722650(-) m6A 3'UTR//CDS//exon       27371828 chr19:54722662-54722663(-) m6A 3'UTR//CDS//exon       27371828 chr19:54722695-54722696(-) m6A 3'UTR//CDS//exon       - chr19:54722706-54722707(-) m6A 3'UTR//CDS//exon       - chr19:54722727-54722728(-) m6A exon//intron       - chr19:54723003-54723004(-) m6A 3'UTR//CDS//exon       - chr19:54723010-54723011(-) m6A 3'UTR//CDS//exon       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	LILRB3	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: LILRB3

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.