Detail Information

Basic Information:


  VIRBase ID:  

VHID00508741

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           CCNI:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p CCNI
miRBase
Accession/Entrez ID		 MIMAT0001581 10983
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - CCNI1//CYC1//CYI

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR CCNI
chr4:77976428(-) A-I      NonSyn:Met->Val
chr4:77986020(-) A-I      ncRNA
chr4:77986075(-) A-I      ncRNA
chr4:77986046(-) A-I      ncRNA
chr4:77986025(-) A-I      ncRNA
chr4:77986008(-) A-I      ncRNA
chr4:77986002(-) A-I      ncRNA
chr4:77976433(-) A-I      NonSyn:His->Arg
chr4:77985969(-) A-I      ncRNA
chr4:77976405(-) A-I      Syn:Gln->Gln
chr4:77985965(-) A-I      ncRNA
chr4:77985948(-) A-I      ncRNA
chr4:77976371(-) A-I      NonSyn:Ser->Gly
chr4:77985918(-) A-I      ncRNA
chr4:77976418(-) A-I      NonSyn:Asn->Ser
chr4:77987027(-) A-I      intronic
chr4:77987192(-) A-I      intronic
chr4:77987207(-) A-I      intronic
chr4:77988752(-) A-I      intronic
chr4:77988755(-) A-I      intronic
chr4:77985339(-) A-I      intronic
chr4:77985357(-) A-I      intronic
chr4:77987070(-) A-I      intronic
chr4:77987130(-) A-I      intronic
chr4:77987132(-) A-I      intronic
chr4:77987168(-) A-I      intronic
chr4:77987171(-) A-I      intronic
chr4:77987210(-) A-I      intronic
chr4:77991243(-) A-I      intronic
chr4:77991268(-) A-I      intronic
chr4:77991273(-) A-I      intronic
chr4:77982891(-) A-I      intronic
chr4:77982899(-) A-I      intronic
chr4:77980681(-) A-I      intronic
chr4:77991287(-) A-I      intronic
chr4:77980333(-) A-I      intronic
chr4:77983502(-) A-I      intronic
chr4:77983499(-) A-I      intronic
chr4:77985232(-) A-I      intronic
chr4:77983515(-) A-I      intronic
chr4:77980348(-) A-I      intronic
chr4:77980354(-) A-I      intronic
chr4:77980656(-) A-I      intronic
chr4:77980670(-) A-I      intronic
chr4:77983027(-) A-I      intronic
chr4:77980689(-) A-I      intronic
chr4:77980699(-) A-I      intronic
chr4:77980755(-) A-I      intronic
chr4:77980763(-) A-I      intronic
chr4:77976668(-) A-I      intronic
chr4:77976708(-) A-I      intronic
chr4:77976768(-) A-I      intronic
chr4:77976790(-) A-I      intronic
chr4:77977832(-) A-I      intronic
chr4:77977854(-) A-I      intronic
chr4:77983601(-) A-I      intronic
chr4:77986996(-) A-I      intronic
chr4:77987197(-) A-I      intronic
chr4:77977950(-) A-I      intronic
chr4:77980787(-) A-I      intronic
chr4:77985229(-) A-I      intronic
chr4:77985223(-) A-I      intronic
chr4:77985215(-) A-I      intronic
chr4:77985178(-) A-I      intronic
chr4:77984705(-) A-I      intronic
chr4:77982947(-) A-I      intronic
chr4:77978011(-) A-I      intronic
chr4:77984675(-) A-I      intronic
chr4:77978017(-) A-I      intronic
chr4:77984661(-) A-I      intronic
chr4:77984653(-) A-I      intronic
chr4:77980795(-) A-I      intronic
chr4:77978025(-) A-I      intronic
chr4:77979283(-) A-I      intronic
chr4:77979291(-) A-I      intronic
chr4:77979422(-) A-I      intronic
chr4:77981915(-) A-I      intronic
chr4:77981923(-) A-I      intronic
chr4:77981924(-) A-I      intronic
chr4:77976884(-) A-I      intronic
chr4:77982920(-) A-I      intronic
chr4:77976788(-) A-I      intronic
chr4:77982934(-) A-I      intronic
chr4:77976813(-) A-I      intronic
chr4:77983028(-) A-I      intronic
chr4:77982951(-) A-I      intronic
chr4:77983006(-) A-I      intronic
chr4:77983088(-) A-I      intronic
chr4:77982997(-) A-I      intronic
chr4:77976748(-) A-I      intronic
chr4:77976784(-) A-I      intronic
chr4:77986005(-) A-I      ncRNA
chr4:77976793(-) A-I      intronic
chr4:77976744(-) A-I      intronic
chr4:77977864(-) A-I      intronic
chr4:77982990(-) A-I      intronic
chr4:77982987(-) A-I      intronic
chr4:77976757(-) A-I      intronic
chr4:77985929(-) A-I      ncRNA
chr4:77988736(-) A-I      intronic
chr4:77985930(-) A-I      ncRNA
chr4:77977878(-) A-I      intronic
chr4:77983017(-) A-I      intronic
chr4:77983101(-) A-I      intronic
chr4:77985900(-) A-I      ncRNA
chr4:77976824(-) A-I      intronic
chr4:77985944(-) A-I      ncRNA
chr4:77982991(-) A-I      intronic
chr4:77982961(-) A-I      intronic
chr4:77988130(-) A-I      intronic
chr4:77976852(-) A-I      intronic
chr4:77976847(-) A-I      intronic
chr4:77976833(-) A-I      intronic
chr4:77983000(-) A-I      intronic
chr4:77982992(-) A-I      intronic
chr4:77987087(-) A-I      intronic
chr4:77985333(-) A-I      intronic
chr4:77989222(-) A-I      intronic
chr4:77985313(-) A-I      intronic
chr4:77989248(-) A-I      intronic
chr4:77982059(-) A-I      intronic
chr4:77985151(-) A-I      intronic
chr4:77985176(-) A-I      intronic
chr4:77987002(-) A-I      intronic
chr4:77981916(-) A-I      intronic
chr4:77989150(-) A-I      intronic
chr4:77983661(-) A-I      intronic
chr4:77977973(-) A-I      intronic
chr4:77988772(-) A-I      intronic
chr4:77982955(-) A-I      intronic
chr4:77981799(-) A-I      intronic
chr4:77990319(-) A-I      intronic
chr4:77982078(-) A-I      intronic
chr4:77976798(-) A-I      intronic
chr4:77988887(-) A-I      intronic
chr4:77988854(-) A-I      intronic
chr4:77987167(-) A-I      intronic
chr4:77987202(-) A-I      intronic
chr4:77985173(-) A-I      intronic
chr4:77983596(-) A-I      intronic
chr4:77988699(-) A-I      intronic
chr4:77987240(-) A-I      intronic
chr4:77985296(-) A-I      intronic
chr4:77984678(-) A-I      intronic
chr4:77979399(-) A-I      intronic
chr4:77979336(-) A-I      intronic
chr4:77976799(-) A-I      intronic
chr4:77991309(-) A-I      intronic
chr4:77987008(-) A-I      intronic
chr4:77985284(-) A-I      intronic
chr4:77988693(-) A-I      intronic
chr4:77984589(-) A-I      intronic
chr4:77991225(-) A-I      intronic
chr4:77970797(-) A-I      intronic
chr4:77987056(-) A-I      intronic
chr4:77983516(-) A-I      intronic
chr4:77985150(-) A-I      intronic
chr4:77990406(-) A-I      intronic
chr4:77977858(-) A-I      intronic
chr4:77979342(-) A-I      intronic
chr4:77988782(-) A-I      intronic
chr4:77979245(-) A-I      intronic
chr4:77977940(-) A-I      intronic
chr4:77976683(-) A-I      intronic
chr4:77988302(-) A-I      intronic
chr4:77989250(-) A-I      intronic
chr4:77989218(-) A-I      intronic
chr4:77983547(-) A-I      intronic
chr4:77988740(-) A-I      intronic
chr4:77990327(-) A-I      intronic
chr4:77983517(-) A-I      intronic
chr4:77987159(-) A-I      intronic
chr4:77976823(-) A-I      intronic
chr4:77976796(-) A-I      intronic
chr4:77979380(-) A-I      intronic
chr4:77970659(-) A-I      intronic
chr4:77987191(-) A-I      intronic
chr4:77983094(-) A-I      intronic
chr4:77979396(-) A-I      intronic
chr4:77989209(-) A-I      intronic
chr4:77977871(-) A-I      intronic
chr4:77989080(-) A-I      intronic
chr4:77988811(-) A-I      intronic
chr4:77977946(-) A-I      intronic
chr4:77982919(-) A-I      intronic
chr4:77985160(-) A-I      intronic
chr4:77981756(-) A-I      intronic
chr4:77977881(-) A-I      intronic
chr4:77981873(-) A-I      intronic
chr4:77981713(-) A-I      intronic
chr4:77985925(-) A-I      ncRNA
chr4:77986106(-) A-I      ncRNA
chr4:77986011(-) A-I      ncRNA
chr4:77986000(-) A-I      ncRNA
chr4:77986065(-) A-I      ncRNA
chr4:77985996(-) A-I      ncRNA
chr4:77985939(-) A-I      ncRNA
chr4:77986026(-) A-I      ncRNA
chr4:77986010(-) A-I      ncRNA
chr4:77986007(-) A-I      ncRNA
chr4:77986083(-) A-I      ncRNA
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED CCNI
chr4:77979680(-) A-I exon CDS    19478186   //21960545
chr4:77983094(-) A-I intron -    22028664   //22327324
chr4:77976744(-) A-I intron -    22028664
chr4:77976748(-) A-I intron -    22028664
chr4:77976757(-) A-I intron -    22028664
chr4:77976784(-) A-I intron -    22028664
chr4:77976788(-) A-I intron -    22028664
chr4:77976793(-) A-I intron -    22028664
chr4:77976796(-) A-I intron -    22028664
chr4:77976813(-) A-I intron -    22028664
chr4:77976823(-) A-I intron -    22028664
chr4:77976824(-) A-I intron -    22028664
chr4:77976833(-) A-I intron -    22028664
chr4:77976847(-) A-I intron -    22028664
chr4:77976852(-) A-I intron -    22028664
chr4:77976884(-) A-I intron -    22028664
chr4:77982919(-) A-I intron -    22028664
chr4:77982920(-) A-I intron -    22028664
chr4:77982934(-) A-I intron -    22028664
chr4:77982951(-) A-I intron -    22028664
chr4:77982955(-) A-I intron -    22028664
chr4:77982961(-) A-I intron -    22028664
chr4:77982987(-) A-I intron -    22028664
chr4:77982990(-) A-I intron -    22028664
chr4:77982991(-) A-I intron -    22028664
chr4:77982992(-) A-I intron -    22028664
chr4:77982997(-) A-I intron -    22028664
chr4:77983000(-) A-I intron -    22028664
chr4:77983006(-) A-I intron -    22028664
chr4:77983017(-) A-I intron -    22028664
chr4:77983028(-) A-I intron -    22028664
chr4:77983088(-) A-I intron -    22028664
chr4:77983095(-) A-I intron -    22028664
chr4:77983101(-) A-I intron -    22028664
chr4:77980220(-) A-I intron -    21960545
chr4:77987056(-) A-I intron -    21960545
chr4:77997047(-) C-T intron -    21725310
chr4:77976617(-) G-A intron -    22484847
chr4:77977878(-) A-G intron -    22484847
chr4:77977946(-) A-G intron -    22484847
chr4:77977973(-) A-G intron -    22484847
chr4:77982955(-) A-G intron -    22484847
chr4:77983094(-) A-G intron -    22484847
chr4:77983596(-) A-G intron -    22484847
chr4:77983651(-) A-G intron -    22484847
chr4:77985150(-) A-G intron -    22484847
chr4:77985151(-) A-G intron -    22484847
chr4:77985173(-) A-G intron -    22484847
chr4:77986011(-) A-G intron -    22484847
chr4:77986014(-) A-G intron -    22484847
chr4:77987008(-) A-G intron -    22484847
chr4:77987056(-) A-G intron -    22484847
chr4:77987096(-) A-G intron -    22484847
chr4:77987191(-) A-G intron -    22484847
chr4:77987202(-) A-G intron -    22484847
chr4:77987240(-) A-G intron -    22484847
chr4:77988746(-) A-G intron -    22484847
chr4:77988817(-) C-A intron -    22484847
chr4:77989080(-) A-G intron -    22484847
chr4:77991308(-) A-G intron -    22484847
chr4:77991309(-) A-G intron -    22484847
chr4:77993659(-) T-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CCNI
chr4:77968552-77968553(-) m6A 3'UTR       26404942
chr4:77968622-77968623(-) m6A 3'UTR       26404942
chr4:77968913-77968914(-) m6A 3'UTR       26404942
chr4:77968959-77968960(-) m6A 3'UTR       26404942
chr4:77969134-77969135(-) m6A 3'UTR       26404942
chr4:77969145-77969146(-) m6A 3'UTR       26404942
chr4:77969180-77969181(-) m6A 3'UTR       24981863//26404942
chr4:77969234-77969235(-) m6A 3'UTR       24981863//26404942
chr4:77969308-77969309(-) Am 3'UTR       -
chr4:77969314-77969315(-) m6A 3'UTR       24981863//26404942
chr4:77969332-77969333(-) m6A 3'UTR       24981863//26404942
chr4:77969342-77969343(-) m6A 3'UTR       24981863//26404942
chr4:77969416-77969417(-) m6A CDS       24981863//26404942
chr4:77969425-77969426(-) m6A CDS       24981863//26404942
chr4:77969550-77969551(-) m6A CDS       24981863//26404942
chr4:77969630-77969631(-) m6A CDS       24981863//26404942//22575960
chr4:77969642-77969643(-) m6A CDS       24981863//26404942//22575960
chr4:77977189-77977190(-) Gm 3'UTR//CDS//exon       -
chr4:77979709-77979710(-) m6A CDS//exon//intron       -
chr4:77979740-77979741(-) m6A CDS//exon//intron       -
chr4:77985928-77985929(-) m6A exon//intron       -
chr4:77995963-77995964(-) m6A 5'UTR//intron       24981863
chr4:77996429-77996430(-) m6A 5'UTR//intron       24981863
chr4:77996465-77996466(-) m6A 5'UTR//intron       24981863
chr4:77996866-77996867(-) m6A 5'UTR       27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate CCNI
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleoplasm K562 cells     -
Nucleus K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: CCNI

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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