Detail Information

Basic Information:


  VIRBase ID:  

VHID00508708

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           KDELR1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p KDELR1
miRBase
Accession/Entrez ID		 MIMAT0001581 10945
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - ERD2//ERD2.1//HDEL//PM23

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR KDELR1
chr19:48889469(-) A-I      intronic
chr19:48889487(-) A-I      intronic
chr19:48892392(-) A-I      intronic
chr19:48892403(-) A-I      intronic
chr19:48892407(-) A-I      intronic
chr19:48892415(-) A-I      intronic
chr19:48892427(-) A-I      intronic
chr19:48892437(-) A-I      intronic
chr19:48892440(-) A-I      intronic
chr19:48892441(-) A-I      intronic
chr19:48892444(-) A-I      intronic
chr19:48892451(-) A-I      intronic
chr19:48889483(-) A-I      intronic
chr19:48889474(-) A-I      intronic
chr19:48888196(-) A-I      intronic
chr19:48888229(-) A-I      intronic
chr19:48891886(-) A-I      intronic
chr19:48891896(-) A-I      intronic
chr19:48890891(-) A-I      intronic
chr19:48890080(-) A-I      intronic
chr19:48890209(-) A-I      intronic
chr19:48890241(-) A-I      intronic
chr19:48890246(-) A-I      intronic
chr19:48890759(-) A-I      intronic
chr19:48888235(-) A-I      intronic
chr19:48888236(-) A-I      intronic
chr19:48888282(-) A-I      intronic
chr19:48891795(-) A-I      intronic
chr19:48889577(-) A-I      intronic
chr19:48889790(-) A-I      intronic
chr19:48889810(-) A-I      intronic
chr19:48889875(-) A-I      intronic
chr19:48889883(-) A-I      intronic
chr19:48889575(-) A-I      intronic
chr19:48889825(-) A-I      intronic
chr19:48890216(-) A-I      intronic
chr19:48889500(-) A-I      intronic
chr19:48889443(-) A-I      intronic
chr19:48889843(-) A-I      intronic
chr19:48890689(-) A-I      intronic
chr19:48889977(-) A-I      intronic
chr19:48890719(-) A-I      intronic
chr19:48890790(-) A-I      intronic
chr19:48890242(-) A-I      intronic
chr19:48890135(-) A-I      intronic
chr19:48889542(-) A-I      intronic
chr19:48890827(-) A-I      intronic
chr19:48889509(-) A-I      intronic
chr19:48889982(-) A-I      intronic
chr19:48888272(-) A-I      intronic
chr19:48890718(-) A-I      intronic
chr19:48889540(-) A-I      intronic
chr19:48890817(-) A-I      intronic
chr19:48890862(-) A-I      intronic
chr19:48889488(-) A-I      intronic
chr19:48890206(-) A-I      intronic
chr19:48888181(-) A-I      intronic
chr19:48890167(-) A-I      intronic
chr19:48889567(-) A-I      intronic
chr19:48890228(-) A-I      intronic
chr19:48889974(-) A-I      intronic
chr19:48889990(-) A-I      intronic
chr19:48889878(-) A-I      intronic
chr19:48890776(-) A-I      intronic
chr19:48890161(-) A-I      intronic
chr19:48889842(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED KDELR1
chr19:48889842(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase KDELR1
chr19:48885831-48885832(-) m6A 3'UTR       27773535
chr19:48885846-48885847(-) m6A 3'UTR       27773535
chr19:48885879-48885880(-) m6A 3'UTR       27773535
chr19:48886096-48886097(-) m6A 3'UTR       24981863//26404942//27773535
chr19:48886146-48886147(-) m6A 3'UTR       24981863//26404942//27773535
chr19:48886337-48886338(-) m6A 3'UTR       27773535
chr19:48886369-48886370(-) m6A 3'UTR       27773535
chr19:48886402-48886403(-) m6A 3'UTR       27773535
chr19:48886491-48886492(-) Am 3'UTR       -
chr19:48893723-48893724(-) m6A 5'UTR//CDS//exon       27773535
chr19:48893787-48893788(-) m6A 5'UTR//intron       27773535
chr19:48894098-48894099(-) m6A 5'UTR//intron       -
chr19:48894109-48894110(-) m6A 5'UTR//intron       24284625//25456834
chr19:48894589-48894590(-) m6A CDS//exon       24284625//25456834//24981863//28052920//27773535
chr19:48894687-48894688(-) m6A 5'UTR//exon       24284625//25456834//24981863//28052920//27773535//27773536//22575960

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate KDELR1
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)|K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus HCC cell line (HepG2)|K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: KDELR1

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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