Basic Information:

  VIRBase ID:  

VHID00508693

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          DBF4:  NM_001318061     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	DBF4
miRBase Accession/Entrez ID	MIMAT0001581	10926
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	ASK//CHIF//DBF4A//ZDBF1

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	DBF4	chr7:87535366(+) A-I      intronic chr7:87535344(+) A-I      intronic chr7:87527927(+) A-I      intronic chr7:87534366(+) A-I      intronic chr7:87533221(+) A-I      intronic chr7:87533220(+) A-I      intronic chr7:87533194(+) A-I      intronic chr7:87510571(+) A-I      intronic chr7:87510569(+) A-I      intronic chr7:87527943(+) A-I      intronic chr7:87527999(+) A-I      intronic chr7:87528002(+) A-I      intronic chr7:87518002(+) A-I      intronic chr7:87509147(+) A-I      intronic chr7:87528076(+) A-I      intronic chr7:87509115(+) A-I      intronic chr7:87508511(+) A-I      intronic chr7:87518612(+) A-I      intronic chr7:87518648(+) A-I      intronic chr7:87508484(+) A-I      intronic chr7:87522641(+) A-I      intronic chr7:87522700(+) A-I      intronic chr7:87522759(+) A-I      intronic chr7:87522767(+) A-I      intronic chr7:87522771(+) A-I      intronic chr7:87522820(+) A-I      intronic chr7:87508416(+) A-I      intronic chr7:87510444(+) A-I      intronic chr7:87508393(+) A-I      intronic chr7:87508337(+) A-I      intronic chr7:87518778(+) A-I      intronic chr7:87518675(+) A-I      intronic chr7:87509117(+) A-I      intronic chr7:87518816(+) A-I      intronic chr7:87519762(+) A-I      intronic chr7:87519767(+) A-I      intronic chr7:87523585(+) A-I      intronic chr7:87508516(+) A-I      intronic chr7:87509126(+) A-I      intronic chr7:87523700(+) A-I      intronic chr7:87519590(+) A-I      intronic chr7:87527145(+) A-I      intronic chr7:87523572(+) A-I      intronic chr7:87523628(+) A-I      intronic chr7:87513564(+) A-I      intronic chr7:87533937(+) A-I      intronic chr7:87533250(+) A-I      intronic chr7:87523575(+) A-I      intronic chr7:87523701(+) A-I      intronic chr7:87519684(+) A-I      intronic chr7:87534302(+) A-I      intronic chr7:87523644(+) A-I      intronic chr7:87509066(+) A-I      intronic chr7:87518664(+) A-I      intronic chr7:87527290(+) A-I      intronic chr7:87527293(+) A-I      intronic chr7:87518674(+) A-I      intronic chr7:87508332(+) A-I      intronic chr7:87527219(+) A-I      intronic chr7:87519779(+) A-I      intronic chr7:87523564(+) A-I      intronic chr7:87534359(+) A-I      intronic chr7:87527882(+) A-I      intronic chr7:87528069(+) A-I      intronic chr7:87527138(+) A-I      intronic chr7:87534395(+) A-I      intronic chr7:87534291(+) A-I      intronic chr7:87523509(+) A-I      intronic chr7:87519727(+) A-I      intronic chr7:87527111(+) A-I      intronic chr7:87527909(+) A-I      intronic chr7:87527197(+) A-I      intronic chr7:87535267(+) A-I      intronic chr7:87527193(+) A-I      intronic chr7:87533936(+) A-I      intronic chr7:87523584(+) A-I      intronic chr7:87509065(+) A-I      intronic chr7:87523632(+) A-I      intronic chr7:87519768(+) A-I      intronic chr7:87508492(+) A-I      intronic chr7:87527276(+) A-I      intronic chr7:87533136(+) A-I      intronic chr7:87527273(+) A-I      intronic chr7:87519726(+) A-I      intronic chr7:87510493(+) A-I      intronic chr7:87534405(+) A-I      intronic chr7:87527919(+) A-I      intronic chr7:87527218(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	DBF4	chr7:87527138(+) A-I intron -    22327324 chr7:87523509(+) A-I intron -    22028664 chr7:87523521(+) A-I intron -    22028664 chr7:87523572(+) A-I intron -    22028664 chr7:87523575(+) A-I intron -    22028664 chr7:87523584(+) A-I intron -    22028664 chr7:87523585(+) A-I intron -    22028664 chr7:87523612(+) A-I intron -    22028664 chr7:87523628(+) A-I intron -    22028664 chr7:87523632(+) A-I intron -    22028664 chr7:87523644(+) A-I intron -    22028664 chr7:87523654(+) A-I intron -    22028664 chr7:87523700(+) A-I intron -    22028664 chr7:87523701(+) A-I intron -    22028664 chr7:87508332(+) A-G intron -    22484847 chr7:87508447(+) A-G intron -    22484847 chr7:87508492(+) A-G intron -    22484847 chr7:87509038(+) A-G intron -    22484847 chr7:87509041(+) T-C intron -    22484847 chr7:87509057(+) A-G intron -    22484847 chr7:87509065(+) A-G intron -    22484847 chr7:87509066(+) A-G intron -    22484847 chr7:87509126(+) A-G intron -    22484847 chr7:87518724(+) A-G intron -    22484847 chr7:87519590(+) A-G intron -    22484847 chr7:87519726(+) A-G intron -    22484847 chr7:87519727(+) A-G intron -    22484847 chr7:87519735(+) T-C intron -    22484847 chr7:87519768(+) A-G intron -    22484847 chr7:87523509(+) A-G intron -    22484847 chr7:87523584(+) A-G intron -    22484847 chr7:87523585(+) A-G intron -    22484847 chr7:87523654(+) A-G intron -    22484847 chr7:87523701(+) A-G intron -    22484847 chr7:87527138(+) A-G intron -    22484847 chr7:87527145(+) A-G intron -    22484847 chr7:87527210(+) A-G intron -    22484847 chr7:87527218(+) A-G intron -    22484847 chr7:87527230(+) T-C intron -    22484847 chr7:87527257(+) T-C intron -    22484847 chr7:87527268(+) T-C intron -    22484847 chr7:87527269(+) T-C intron -    22484847 chr7:87527276(+) A-G intron -    22484847 chr7:87527281(+) T-C intron -    22484847 chr7:87527290(+) A-G intron -    22484847 chr7:87527293(+) A-G intron -    22484847 chr7:87527345(+) A-G intron -    22484847 chr7:87527852(+) A-G intron -    22484847 chr7:87527882(+) A-G intron -    22484847 chr7:87528069(+) A-G intron -    22484847 chr7:87532420(+) T-C intron -    22484847 chr7:87533214(+) T-C intron -    22484847 chr7:87533974(+) T-C intron -    22484847 chr7:87534011(+) T-C intron -    22484847 chr7:87534291(+) A-G intron -    22484847 chr7:87534302(+) A-G intron -    22484847 chr7:87534359(+) A-G intron -    22484847 chr7:87535390(+) T-C intron -    22484847 chr7:87517988(+) A-G intron -    22484847 chr7:87517989(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	DBF4	chr7:87505563-87505564(+) m6A 5'UTR       25456834 chr7:87505577-87505578(+) m6A 5'UTR       25456834 chr7:87505597-87505598(+) m6A 5'UTR       25456834 chr7:87505637-87505638(+) m6A 5'UTR       25456834 chr7:87505888-87505889(+) m6A 5'UTR//exon       24981863 chr7:87517316-87517317(+) m6A 3'UTR//CDS//exon       24981863 chr7:87525534-87525535(+) m6A exon//intron       24981863 chr7:87533712-87533713(+) m6A 3'UTR//CDS//exon       24981863//27773535//22608085 chr7:87536557-87536558(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085 chr7:87536562-87536563(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085 chr7:87536656-87536657(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085 chr7:87536665-87536666(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085 chr7:87536787-87536788(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr7:87536819-87536820(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr7:87536823-87536824(+) m6A 3'UTR//CDS       27773535//22575960 chr7:87536850-87536851(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr7:87536880-87536881(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr7:87536967-87536968(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr7:87537017-87537018(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr7:87537062-87537063(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr7:87537123-87537124(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr7:87537225-87537226(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085 chr7:87537250-87537251(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085 chr7:87537275-87537276(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085 chr7:87537311-87537312(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085 chr7:87537322-87537323(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	DBF4	Chromatin K562 cells     - Exosome Blood     - Membrane K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: DBF4

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.