Basic Information:

  VIRBase ID:  

VHID00508683

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          PAPOLA:  NM_001363665     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	PAPOLA
miRBase Accession/Entrez ID	MIMAT0001581	10914
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	PAP//PAP-alpha

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PAPOLA	chr14:97028491(+) A-I      intronic chr14:97028503(+) A-I      intronic chr14:96995872(+) A-I      intronic chr14:96980717(+) A-I      intronic chr14:96992809(+) A-I      intronic chr14:96995902(+) A-I      intronic chr14:96988817(+) A-I      intronic chr14:96996793(+) A-I      intronic chr14:96991941(+) A-I      intronic chr14:96991967(+) A-I      intronic chr14:97028490(+) A-I      intronic chr14:96985229(+) A-I      intronic chr14:96972438(+) A-I      intronic chr14:96991010(+) A-I      intronic chr14:97019979(+) A-I      intronic chr14:96970875(+) A-I      intronic chr14:97000097(+) A-I      intronic chr14:97019600(+) A-I      intronic chr14:96996008(+) A-I      intronic chr14:97015792(+) A-I      intronic chr14:96975402(+) A-I      intronic chr14:96996911(+) A-I      intronic chr14:96996000(+) A-I      intronic chr14:97019697(+) A-I      intronic chr14:96970917(+) A-I      intronic chr14:97019727(+) A-I      intronic chr14:96995912(+) A-I      intronic chr14:96970784(+) A-I      intronic chr14:97019588(+) A-I      intronic chr14:96996759(+) A-I      intronic chr14:96996824(+) A-I      intronic chr14:96995980(+) A-I      intronic chr14:96990907(+) A-I      intronic chr14:96997419(+) A-I      intronic chr14:96972341(+) A-I      intronic chr14:97020058(+) A-I      intronic chr14:96985351(+) A-I      intronic chr14:96988036(+) A-I      intronic chr14:96988368(+) A-I      intronic chr14:96988860(+) A-I      intronic chr14:96988902(+) A-I      intronic chr14:96988942(+) A-I      intronic chr14:96990084(+) A-I      intronic chr14:96990090(+) A-I      intronic chr14:96990160(+) A-I      intronic chr14:96990201(+) A-I      intronic chr14:97019805(+) A-I      intronic chr14:96990212(+) A-I      intronic chr14:96990225(+) A-I      intronic chr14:96990880(+) A-I      intronic chr14:96990884(+) A-I      intronic chr14:96991984(+) A-I      intronic chr14:96994987(+) A-I      intronic chr14:96996836(+) A-I      intronic chr14:96995782(+) A-I      intronic chr14:96995804(+) A-I      intronic chr14:96990028(+) A-I      intronic chr14:96995805(+) A-I      intronic chr14:96995871(+) A-I      intronic chr14:96988084(+) A-I      intronic chr14:96985160(+) A-I      intronic chr14:96995896(+) A-I      intronic chr14:96995904(+) A-I      intronic chr14:96997395(+) A-I      intronic chr14:96995944(+) A-I      intronic chr14:96995965(+) A-I      intronic chr14:97019906(+) A-I      intronic chr14:96997245(+) A-I      intronic chr14:96987961(+) A-I      intronic chr14:96997456(+) A-I      intronic chr14:96988916(+) A-I      intronic chr14:96990224(+) A-I      intronic chr14:96996962(+) A-I      intronic chr14:96996823(+) A-I      intronic chr14:96995988(+) A-I      intronic chr14:96996046(+) A-I      intronic chr14:96997469(+) A-I      intronic chr14:96997480(+) A-I      intronic chr14:97019568(+) A-I      intronic chr14:96977716(+) A-I      intronic chr14:96997488(+) A-I      intronic chr14:97019696(+) A-I      intronic chr14:96997491(+) A-I      intronic chr14:96997515(+) A-I      intronic chr14:96995938(+) A-I      intronic chr14:96997524(+) A-I      intronic chr14:96997549(+) A-I      intronic chr14:96997711(+) A-I      intronic chr14:96997253(+) A-I      intronic chr14:96988050(+) A-I      intronic chr14:97019793(+) A-I      intronic chr14:96990970(+) A-I      intronic chr14:97019668(+) A-I      intronic chr14:96985139(+) A-I      intronic chr14:97019651(+) A-I      intronic chr14:96995916(+) A-I      intronic chr14:96997182(+) A-I      intronic chr14:96970918(+) A-I      intronic chr14:96997658(+) A-I      intronic chr14:96996009(+) A-I      intronic chr14:97016308(+) A-I      intronic chr14:96972380(+) A-I      intronic chr14:97019512(+) A-I      intronic chr14:96979561(+) A-I      intronic chr14:96991961(+) A-I      intronic chr14:96987957(+) A-I      intronic chr14:96972421(+) A-I      intronic chr14:97019601(+) A-I      intronic chr14:96972267(+) A-I      intronic chr14:96985339(+) A-I      intronic chr14:96997545(+) A-I      intronic chr14:96990027(+) A-I      intronic chr14:97019737(+) A-I      intronic chr14:96997694(+) A-I      intronic chr14:97019434(+) A-I      intronic chr14:96991968(+) A-I      intronic chr14:96996592(+) A-I      intronic chr14:96990070(+) A-I      intronic chr14:96995796(+) A-I      intronic chr14:96997326(+) A-I      intronic chr14:96997252(+) A-I      intronic chr14:97019813(+) A-I      intronic chr14:96996864(+) A-I      intronic chr14:96970958(+) A-I      intronic chr14:97023649(+) A-I      intronic chr14:96990071(+) A-I      intronic chr14:96996909(+) A-I      intronic chr14:96996854(+) A-I      intronic chr14:96995899(+) A-I      intronic chr14:97019654(+) A-I      intronic chr14:96985517(+) A-I      intronic chr14:96992787(+) A-I      intronic chr14:97019483(+) A-I      intronic chr14:96988197(+) A-I      intronic chr14:96988044(+) A-I      intronic chr14:97016364(+) A-I      intronic chr14:97019640(+) A-I      intronic chr14:96988956(+) A-I      intronic chr14:97019630(+) A-I      intronic chr14:97030563(+) A-I      intronic chr14:97019517(+) A-I      intronic chr14:96995952(+) A-I      intronic chr14:97019900(+) A-I      intronic chr14:96995857(+) A-I      intronic chr14:96995856(+) A-I      intronic chr14:97020083(+) A-I      intronic chr14:96997478(+) A-I      intronic chr14:96997390(+) A-I      intronic chr14:96985376(+) A-I      intronic chr14:97016288(+) A-I      intronic chr14:96985138(+) A-I      intronic chr14:97019594(+) A-I      intronic chr14:96997650(+) A-I      intronic chr14:97019950(+) A-I      intronic chr14:96997522(+) A-I      intronic chr14:97019903(+) A-I      intronic chr14:97019469(+) A-I      intronic chr14:96989016(+) A-I      intronic chr14:96996851(+) A-I      intronic chr14:96985162(+) A-I      intronic chr14:96995897(+) A-I      intronic chr14:97000021(+) A-I      intronic chr14:96995882(+) A-I      intronic chr14:96997468(+) A-I      intronic chr14:96970762(+) A-I      intronic chr14:96970963(+) A-I      intronic chr14:96997521(+) A-I      intronic chr14:97030643(+) A-I      intronic chr14:97016235(+) A-I      intronic chr14:96997308(+) A-I      intronic chr14:96988180(+) A-I      intronic chr14:97019509(+) A-I      intronic chr14:96978635(+) A-I      intronic chr14:97028497(+) A-I      intronic chr14:97019522(+) A-I      intronic chr14:96991946(+) A-I      intronic chr14:97019741(+) A-I      intronic chr14:96997600(+) A-I      intronic chr14:96997609(+) A-I      intronic chr14:96984275(+) A-I      intronic chr14:96972415(+) A-I      intronic chr14:96997191(+) A-I      intronic chr14:97016441(+) A-I      intronic chr14:96997251(+) A-I      intronic chr14:97019649(+) A-I      intronic chr14:96997599(+) A-I      intronic chr14:97019595(+) A-I      intronic chr14:97019750(+) A-I      intronic chr14:96982895(+) A-I      intronic chr14:96972358(+) A-I      intronic chr14:96968767(+) A-I      5'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PAPOLA	chr14:96968767(+) A-I exon 5'UTR    19478186 chr14:96970918(+) A-I intron -    15258596 chr14:96970958(+) A-I intron -    15258596 chr14:96970963(+) A-I intron -    15258596 chr14:97019524(+) A-I intron -    15258596 chr14:97019601(+) A-I intron -    15258596   //22327324 chr14:97019654(+) A-I intron -    15258596 chr14:97019668(+) A-I intron -    15258596 chr14:97019741(+) A-I intron -    21960545   //22327324 chr14:96992787(+) A-I intron -    21960545 chr14:96996773(+) A-I intron -    21960545 chr14:97030643(+) A-I intron -    21960545 chr14:97019601(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PAPOLA	chr14:96967874-96967875(+) m6A exon       24981863//22608085 chr14:96968815-96968816(+) m6A 5'UTR//CDS//exon//intron       24209618//25456834//24981863//26404942//22575960//22608085 chr14:96969205-96969206(+) m6A 5'UTR//intron       24284625//24209618//24981863 chr14:96970949-96970950(+) m6A exon//intron       - chr14:96971027-96971028(+) m6A exon//intron       26404942 chr14:96986419-96986420(+) m6A 5'UTR//CDS//exon//intron       26404942 chr14:96986482-96986483(+) m6A 5'UTR//CDS//exon//intron       26404942 chr14:96986505-96986506(+) m6A 5'UTR//CDS//exon//intron       26404942 chr14:97022188-97022189(+) m6A 3'UTR//CDS//exon       27773535 chr14:97022537-97022538(+) m6A 3'UTR//CDS       27773535 chr14:97022613-97022614(+) m6A 3'UTR//CDS       27773535 chr14:97022699-97022700(+) m6A 3'UTR//CDS       24981863//27773535 chr14:97022735-97022736(+) m6A 3'UTR//CDS       24981863//27773535 chr14:97022741-97022742(+) m6A 3'UTR//CDS       24981863//27773535 chr14:97026828-97026829(+) m6A exon//intron       24981863//27773535 chr14:97026844-97026845(+) m6A exon//intron       24981863//27773535 chr14:97026981-97026982(+) m6A exon//intron       24284625 chr14:97026991-97026992(+) m6A 3'UTR//CDS//exon//intron       24284625 chr14:97027026-97027027(+) m6A 3'UTR//CDS//exon//intron       24284625 chr14:97027036-97027037(+) m6A 3'UTR//CDS//exon//intron       24284625 chr14:97028798-97028799(+) m6A exon//intron       24284625 chr14:97029157-97029158(+) m6A 3'UTR//CDS//exon//intron       24284625//24981863//22608085 chr14:97029173-97029174(+) m6A 3'UTR//CDS//exon//intron       24284625//24981863//27773535//22608085 chr14:97029194-97029195(+) m6A 3'UTR//CDS//exon//intron       24284625//24981863//27773535//22608085 chr14:97029203-97029204(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//24981863//27773535//22608085 chr14:97031294-97031295(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr14:97031307-97031308(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr14:97031368-97031369(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr14:97031389-97031390(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr14:97031409-97031410(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr14:97031472-97031473(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr14:97031477-97031478(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr14:97031637-97031638(+) m6A 3'UTR       24284625//24981863//22608085 chr14:97032261-97032262(+) m6A 3'UTR       27773535 chr14:97032297-97032298(+) m6A 3'UTR       27773535 chr14:97033298-97033299(+) m6A 3'UTR       27773535 chr14:97033397-97033398(+) m6A 3'UTR       27773535 chr14:97033423-97033424(+) m6A 3'UTR       27773535 chr14:97033439-97033440(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	PAPOLA	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: PAPOLA

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.