Basic Information:

  VIRBase ID:  

VHID00508664

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          MALT1:  NM_173844     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	MALT1
miRBase Accession/Entrez ID	MIMAT0001581	10892
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	IMD12//MLT//MLT1//PCASP1

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MALT1	chr18:56398323(+) A-I      intronic chr18:56398313(+) A-I      intronic chr18:56418390(+) A-I      3'UTR chr18:56419846(+) A-I      3'UTR chr18:56398310(+) A-I      intronic chr18:56403338(+) A-I      intronic chr18:56400236(+) A-I      intronic chr18:56394639(+) A-I      intronic chr18:56356223(+) A-I      intronic chr18:56356222(+) A-I      intronic chr18:56356208(+) A-I      intronic chr18:56356169(+) A-I      intronic chr18:56356206(+) A-I      intronic chr18:56356183(+) A-I      intronic chr18:56373623(+) A-I      intronic chr18:56419977(+) A-I      3'UTR chr18:56372556(+) A-I      intronic chr18:56386971(+) A-I      intronic chr18:56398365(+) A-I      intronic chr18:56398341(+) A-I      intronic chr18:56398372(+) A-I      intronic chr18:56398371(+) A-I      intronic chr18:56398368(+) A-I      intronic chr18:56370335(+) A-I      intronic chr18:56370341(+) A-I      intronic chr18:56368124(+) A-I      intronic chr18:56340780(+) A-I      intronic chr18:56360517(+) A-I      intronic chr18:56347994(+) A-I      intronic chr18:56347978(+) A-I      intronic chr18:56347971(+) A-I      intronic chr18:56347216(+) A-I      intronic chr18:56340873(+) A-I      intronic chr18:56347183(+) A-I      intronic chr18:56346909(+) A-I      intronic chr18:56346865(+) A-I      intronic chr18:56346805(+) A-I      intronic chr18:56405091(+) A-I      intronic chr18:56405058(+) A-I      intronic chr18:56405037(+) A-I      intronic chr18:56404908(+) A-I      intronic chr18:56404865(+) A-I      intronic chr18:56342718(+) A-I      intronic chr18:56342716(+) A-I      intronic chr18:56404505(+) A-I      intronic chr18:56404504(+) A-I      intronic chr18:56404479(+) A-I      intronic chr18:56400309(+) A-I      intronic chr18:56400308(+) A-I      intronic chr18:56394827(+) A-I      intronic chr18:56393288(+) A-I      intronic chr18:56392529(+) A-I      intronic chr18:56371882(+) A-I      intronic chr18:56371864(+) A-I      intronic chr18:56371815(+) A-I      intronic chr18:56342710(+) A-I      intronic chr18:56371806(+) A-I      intronic chr18:56371789(+) A-I      intronic chr18:56371788(+) A-I      intronic chr18:56371710(+) A-I      intronic chr18:56370538(+) A-I      intronic chr18:56370478(+) A-I      intronic chr18:56370427(+) A-I      intronic chr18:56368225(+) A-I      intronic chr18:56370411(+) A-I      intronic chr18:56404563(+) A-I      intronic chr18:56420032(+) A-I      3'UTR chr18:56420674(+) A-I      3'UTR chr18:56419893(+) A-I      3'UTR chr18:56418459(+) A-I      3'UTR chr18:56420014(+) A-I      3'UTR chr18:56418514(+) A-I      3'UTR chr18:56420673(+) A-I      3'UTR chr18:56419782(+) A-I      3'UTR chr18:56419801(+) A-I      3'UTR chr18:56418500(+) A-I      3'UTR chr18:56420625(+) A-I      3'UTR chr18:56420573(+) A-I      3'UTR chr18:56419815(+) A-I      3'UTR chr18:56419880(+) A-I      3'UTR chr18:56420562(+) A-I      3'UTR chr18:56419747(+) A-I      3'UTR chr18:56420033(+) A-I      3'UTR chr18:56346946(+) A-I      intronic chr18:56393146(+) A-I      intronic chr18:56342700(+) A-I      intronic chr18:56404564(+) A-I      intronic chr18:56369495(+) A-I      intronic chr18:56413293(+) A-I      intronic chr18:56405076(+) A-I      intronic chr18:56404670(+) A-I      intronic chr18:56356125(+) A-I      intronic chr18:56355691(+) A-I      intronic chr18:56393190(+) A-I      intronic chr18:56368098(+) A-I      intronic chr18:56356174(+) A-I      intronic chr18:56369359(+) A-I      intronic chr18:56404980(+) A-I      intronic chr18:56369382(+) A-I      intronic chr18:56370510(+) A-I      intronic chr18:56403329(+) A-I      intronic chr18:56351339(+) A-I      intronic chr18:56400323(+) A-I      intronic chr18:56369591(+) A-I      intronic chr18:56371825(+) A-I      intronic chr18:56346929(+) A-I      intronic chr18:56371828(+) A-I      intronic chr18:56404521(+) A-I      intronic chr18:56404944(+) A-I      intronic chr18:56404914(+) A-I      intronic chr18:56370413(+) A-I      intronic chr18:56404457(+) A-I      intronic chr18:56400243(+) A-I      intronic chr18:56371782(+) A-I      intronic chr18:56405089(+) A-I      intronic chr18:56373347(+) A-I      intronic chr18:56370468(+) A-I      intronic chr18:56371873(+) A-I      intronic chr18:56404367(+) A-I      intronic chr18:56351348(+) A-I      intronic chr18:56404876(+) A-I      intronic chr18:56420591(+) A-I      3'UTR chr18:56369536(+) A-I      intronic chr18:56420660(+) A-I      3'UTR chr18:56419797(+) A-I      3'UTR chr18:56418542(+) A-I      3'UTR chr18:56419934(+) A-I      3'UTR chr18:56403242(+) A-I      intronic chr18:56418566(+) A-I      3'UTR chr18:56419764(+) A-I      3'UTR chr18:56419755(+) A-I      3'UTR chr18:56420470(+) A-I      3'UTR chr18:56418643(+) A-I      3'UTR chr18:56420020(+) A-I      3'UTR chr18:56405050(+) A-I      intronic chr18:56369509(+) A-I      intronic chr18:56420701(+) A-I      3'UTR chr18:56419756(+) A-I      3'UTR chr18:56420636(+) A-I      3'UTR chr18:56418415(+) A-I      3'UTR chr18:56419825(+) A-I      3'UTR chr18:56419452(+) A-I      3'UTR chr18:56420715(+) A-I      3'UTR chr18:56419788(+) A-I      3'UTR chr18:56405004(+) A-I      intronic chr18:56419911(+) A-I      3'UTR chr18:56420488(+) A-I      3'UTR chr18:56420713(+) A-I      3'UTR chr18:56403257(+) A-I      intronic chr18:56419885(+) A-I      3'UTR chr18:56418570(+) A-I      3'UTR chr18:56418464(+) A-I      3'UTR chr18:56420565(+) A-I      3'UTR chr18:56368277(+) A-I      intronic chr18:56371750(+) A-I      intronic chr18:56420619(+) A-I      3'UTR chr18:56404956(+) A-I      intronic chr18:56404612(+) A-I      intronic chr18:56419869(+) A-I      3'UTR chr18:56420567(+) A-I      3'UTR chr18:56420505(+) A-I      3'UTR chr18:56418493(+) A-I      3'UTR chr18:56419761(+) A-I      3'UTR chr18:56420555(+) A-I      3'UTR chr18:56371956(+) A-I      intronic chr18:56420526(+) A-I      3'UTR chr18:56418583(+) A-I      3'UTR chr18:56404954(+) A-I      intronic chr18:56419928(+) A-I      3'UTR chr18:56420553(+) A-I      3'UTR chr18:56419971(+) A-I      3'UTR chr18:56420525(+) A-I      3'UTR chr18:56420458(+) A-I      3'UTR chr18:56420506(+) A-I      3'UTR chr18:56420659(+) A-I      3'UTR chr18:56418445(+) A-I      3'UTR chr18:56418561(+) A-I      3'UTR chr18:56400269(+) A-I      intronic chr18:56419783(+) A-I      3'UTR chr18:56418424(+) A-I      3'UTR chr18:56420606(+) A-I      3'UTR chr18:56420700(+) A-I      3'UTR chr18:56418642(+) A-I      3'UTR chr18:56419465(+) A-I      3'UTR chr18:56418450(+) A-I      3'UTR chr18:56377778(+) A-I      intronic chr18:56420019(+) A-I      3'UTR chr18:56370329(+) A-I      intronic chr18:56418449(+) A-I      3'UTR chr18:56369426(+) A-I      intronic chr18:56419992(+) A-I      3'UTR chr18:56368164(+) A-I      intronic chr18:56419935(+) A-I      3'UTR chr18:56418517(+) A-I      3'UTR chr18:56419834(+) A-I      3'UTR chr18:56419886(+) A-I      3'UTR chr18:56419451(+) A-I      3'UTR chr18:56420616(+) A-I      3'UTR chr18:56356237(+) A-I      intronic chr18:56373237(+) A-I      intronic chr18:56420624(+) A-I      3'UTR chr18:56403300(+) A-I      intronic chr18:56371819(+) A-I      intronic chr18:56347234(+) A-I      intronic chr18:56404371(+) A-I      intronic chr18:56400196(+) A-I      intronic chr18:56400343(+) A-I      intronic chr18:56405024(+) A-I      intronic chr18:56353542(+) A-I      intronic chr18:56370438(+) A-I      intronic chr18:56371818(+) A-I      intronic chr18:56404941(+) A-I      intronic chr18:56404571(+) A-I      intronic chr18:56404555(+) A-I      intronic chr18:56355664(+) A-I      intronic chr18:56369535(+) A-I      intronic chr18:56400260(+) A-I      intronic chr18:56371854(+) A-I      intronic chr18:56400229(+) A-I      intronic chr18:56370495(+) A-I      intronic chr18:56393128(+) A-I      intronic chr18:56370514(+) A-I      intronic chr18:56404317(+) A-I      intronic chr18:56371720(+) A-I      intronic chr18:56371938(+) A-I      intronic chr18:56368117(+) A-I      intronic chr18:56368039(+) A-I      intronic chr18:56394782(+) A-I      intronic chr18:56396546(+) A-I      intronic chr18:56404526(+) A-I      intronic chr18:56370332(+) A-I      intronic chr18:56368123(+) A-I      intronic chr18:56405015(+) A-I      intronic chr18:56369603(+) A-I      intronic chr18:56404683(+) A-I      intronic chr18:56404863(+) A-I      intronic chr18:56404587(+) A-I      intronic chr18:56405049(+) A-I      intronic chr18:56368211(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	MALT1	chr18:56370329(+) A-I intron -    22327324 chr18:56386252(+) A-I intron -    22327324 chr18:56404434(+) A-I intron -    22327324 chr18:56404571(+) A-I intron -    22327324 chr18:56386252(+) A-G intron -    22484847 chr18:56369328(+) A-G intron -    22484847 chr18:56369335(+) A-G intron -    22484847 chr18:56369495(+) A-G intron -    22484847 chr18:56369536(+) A-G intron -    22484847 chr18:56370329(+) A-G intron -    22484847 chr18:56370438(+) A-G intron -    22484847 chr18:56370469(+) A-G intron -    22484847 chr18:56370503(+) C-T intron -    22484847 chr18:56371750(+) A-G intron -    22484847 chr18:56371801(+) A-G intron -    22484847 chr18:56403300(+) A-G intron -    22484847 chr18:56403304(+) A-G intron -    22484847 chr18:56403318(+) A-G intron -    22484847 chr18:56404434(+) A-G intron -    22484847 chr18:56404457(+) A-G intron -    22484847 chr18:56404571(+) A-G intron -    22484847 chr18:56404587(+) A-G intron -    22484847 chr18:56404670(+) A-G intron -    22484847 chr18:56404863(+) A-G intron -    22484847 chr18:56404876(+) A-G intron -    22484847 chr18:56404914(+) A-G intron -    22484847 chr18:56405004(+) A-G intron -    22484847 chr18:56405024(+) A-G intron -    22484847 chr18:56405049(+) A-G intron -    22484847 chr18:56405077(+) A-G intron -    22484847 chr18:56386976(+) A-G intron -    22484847 chr18:56386985(+) A-G intron -    22484847 chr18:56387006(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MALT1	chr18:56338698-56338699(+) m6A 5'UTR       24981863 chr18:56338891-56338892(+) m6A CDS       24209618 chr18:56400765-56400766(+) m6A CDS//exon       22575960 chr18:56400770-56400771(+) m6A CDS//exon       22575960 chr18:56414638-56414639(+) m6A CDS//exon       24284625//24981863//26404942//22608085 chr18:56414700-56414701(+) m6A CDS//exon       24284625//25456834//24981863//26404942//22575960//22608085 chr18:56414725-56414726(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr18:56414745-56414746(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr18:56414771-56414772(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr18:56414783-56414784(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr18:56414862-56414863(+) m6A CDS//exon       24284625//24981863//22575960//22608085 chr18:56414942-56414943(+) m6A CDS//exon       24284625//24981863//26404942//22575960//22608085 chr18:56415017-56415018(+) m6A CDS//exon       24284625//24981863//26404942//27773535//22608085 chr18:56415144-56415145(+) m6A 3'UTR//exon       24981863//27773535//22608085 chr18:56415206-56415207(+) m6A 3'UTR//exon       24981863//22608085 chr18:56415214-56415215(+) m6A 3'UTR//exon       24981863//22608085 chr18:56415250-56415251(+) m6A 3'UTR//exon       24981863//22608085 chr18:56416178-56416179(+) m6A 3'UTR       24981863 chr18:56416183-56416184(+) m6A 3'UTR       24981863 chr18:56416196-56416197(+) m6A 3'UTR       24981863 chr18:56416226-56416227(+) m6A 3'UTR       24981863 chr18:56417096-56417097(+) m6A 3'UTR       24981863 chr18:56417137-56417138(+) m6A 3'UTR       24981863 chr18:56417286-56417287(+) m6A 3'UTR       27773535 chr18:56417630-56417631(+) m6A 3'UTR       - chr18:56417660-56417661(+) m6A 3'UTR       - chr18:56417678-56417679(+) m6A 3'UTR       - chr18:56417691-56417692(+) m6A 3'UTR       - chr18:56417743-56417744(+) m6A 3'UTR       - chr18:56417764-56417765(+) m6A 3'UTR       - chr18:56417786-56417787(+) m6A 3'UTR       - chr18:56417791-56417792(+) m6A 3'UTR       - chr18:56417805-56417806(+) m6A 3'UTR       - chr18:56417894-56417895(+) m6A 3'UTR       - chr18:56417978-56417979(+) m6A 3'UTR       - chr18:56417998-56417999(+) m6A 3'UTR       - chr18:56418012-56418013(+) m6A 3'UTR       - chr18:56418058-56418059(+) m6A 3'UTR       - chr18:56418091-56418092(+) m6A 3'UTR       - chr18:56418107-56418108(+) m6A 3'UTR       - chr18:56418140-56418141(+) m6A 3'UTR       - chr18:56418214-56418215(+) m6A 3'UTR       - chr18:56418222-56418223(+) m6A 3'UTR       - chr18:56418271-56418272(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	MALT1	Cytosol HCC cell line (HepG2)     - Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: MALT1

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.