Basic Information:

  VIRBase ID:  

VHID00508639

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          ADAM28:  NR_130709     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	ADAM28
miRBase Accession/Entrez ID	MIMAT0001581	10863
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	ADAM 28//eMDC II//eMDCII//MDC-L//MDCL

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ADAM28	chr8:24162360(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ADAM28	chr8:24151599-24151600(+) m6A 5'UTR       24981863 chr8:24151636-24151637(+) m6A 5'UTR       24981863 chr8:24157502-24157503(+) m6A CDS//exon       24981863 chr8:24157544-24157545(+) m6A CDS//exon       24981863 chr8:24211935-24211936(+) m6A 3'UTR       24981863 chr8:24211963-24211964(+) m6A 3'UTR       24981863 chr8:24212056-24212057(+) m6A 3'UTR       24981863 chr8:24212067-24212068(+) m6A 3'UTR       24981863 chr8:24212090-24212091(+) m6A 3'UTR       24981863 chr8:24212104-24212105(+) m6A 3'UTR       24981863 chr8:24212220-24212221(+) m6A 3'UTR       24981863 chr8:24212225-24212226(+) m6A 3'UTR       24981863 chr8:24212233-24212234(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ADAM28	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: ADAM28

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.