Basic Information:

  VIRBase ID:  

VHID00508598

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          ZNF460:  NM_001330622     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	ZNF460
miRBase Accession/Entrez ID	MIMAT0001581	10794
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	HZF8//ZNF272

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ZNF460	chr19:57801829(+) A-I      intronic chr19:57795150(+) A-I      intronic chr19:57801881(+) A-I      intronic chr19:57794148(+) A-I      intronic chr19:57794156(+) A-I      intronic chr19:57795109(+) A-I      intronic chr19:57795144(+) A-I      intronic chr19:57798120(+) A-I      intronic chr19:57798143(+) A-I      intronic chr19:57798153(+) A-I      intronic chr19:57798154(+) A-I      intronic chr19:57799203(+) A-I      intronic chr19:57799207(+) A-I      intronic chr19:57799214(+) A-I      intronic chr19:57801121(+) A-I      intronic chr19:57801284(+) A-I      intronic chr19:57801353(+) A-I      intronic chr19:57801357(+) A-I      intronic chr19:57801428(+) A-I      intronic chr19:57801866(+) A-I      intronic chr19:57801826(+) A-I      intronic chr19:57801347(+) A-I      intronic chr19:57801528(+) A-I      intronic chr19:57801525(+) A-I      intronic chr19:57799226(+) A-I      intronic chr19:57801811(+) A-I      intronic chr19:57801785(+) A-I      intronic chr19:57801620(+) A-I      intronic chr19:57801541(+) A-I      intronic chr19:57794255(+) A-I      intronic chr19:57799657(+) A-I      intronic chr19:57801323(+) A-I      intronic chr19:57794103(+) A-I      intronic chr19:57801739(+) A-I      intronic chr19:57798144(+) A-I      intronic chr19:57794096(+) A-I      intronic chr19:57801763(+) A-I      intronic chr19:57795104(+) A-I      intronic chr19:57794212(+) A-I      intronic chr19:57794274(+) A-I      intronic chr19:57798877(+) A-I      intronic chr19:57794277(+) A-I      intronic chr19:57799307(+) A-I      intronic chr19:57799210(+) A-I      intronic chr19:57799640(+) A-I      intronic chr19:57794743(+) A-I      intronic chr19:57794638(+) A-I      intronic chr19:57801093(+) A-I      intronic chr19:57799594(+) A-I      intronic chr19:57798874(+) A-I      intronic chr19:57799277(+) A-I      intronic chr19:57795079(+) A-I      intronic chr19:57801527(+) A-I      intronic chr19:57799234(+) A-I      intronic chr19:57801294(+) A-I      intronic chr19:57794252(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ZNF460	chr19:57794277(+) A-I intron -    22327324 chr19:57799640(+) A-I intron -    21960545 chr19:57799656(+) A-I intron -    21960545 chr19:57794277(+) A-G intron -    22484847 chr19:57801270(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZNF460	chr19:57792086-57792087(+) m6A 5'UTR//intron       24284625 chr19:57792132-57792133(+) m6A 5'UTR//intron       24284625 chr19:57793324-57793325(+) m6A 5'UTR//intron       - chr19:57796020-57796021(+) m6A CDS       24284625//24209618//22575960//22608085 chr19:57802079-57802080(+) m6A CDS       24284625//24209618//22575960//22608085 chr19:57802086-57802087(+) m6A CDS       24284625//24209618//22575960//22608085 chr19:57802142-57802143(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr19:57802232-57802233(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr19:57802239-57802240(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr19:57802243-57802244(+) m6A CDS       25456834//24981863 chr19:57802259-57802260(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr19:57802283-57802284(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr19:57802333-57802334(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085 chr19:57802379-57802380(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085 chr19:57802535-57802536(+) m6A CDS       24284625//24981863//22575960//22608085 chr19:57802603-57802604(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr19:57802641-57802642(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr19:57802686-57802687(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr19:57802826-57802827(+) m6A CDS       24284625//22608085 chr19:57803125-57803126(+) m6A CDS       24284625//24981863//26404942//22608085 chr19:57803286-57803287(+) m6A CDS       24284625//24981863//22575960//22608085 chr19:57803293-57803294(+) m6A CDS       24284625//24981863//22575960//22608085 chr19:57803423-57803424(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr19:57803583-57803584(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr19:57803611-57803612(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085 chr19:57803705-57803706(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22575960//22608085 chr19:57803740-57803741(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22575960//22608085 chr19:57803768-57803769(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22575960//22608085 chr19:57803798-57803799(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22575960//22608085 chr19:57803866-57803867(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr19:57803894-57803895(+) m6A 3'UTR       24284625//24981863//26404942//27773535//22575960//22608085 chr19:57803945-57803946(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr19:57803953-57803954(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085 chr19:57804009-57804010(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr19:57804081-57804082(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085 chr19:57804144-57804145(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085 chr19:57804163-57804164(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085 chr19:57804593-57804594(+) m6A 3'UTR       24981863//27773535//22608085 chr19:57804610-57804611(+) m6A 3'UTR       24981863//27773535//22608085 chr19:57804645-57804646(+) m6A 3'UTR       24981863//27773535//22608085 chr19:57804658-57804659(+) m6A 3'UTR       24981863//27773535//22608085 chr19:57804746-57804747(+) m6A 3'UTR       24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ZNF460	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: ZNF460

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.