Basic Information:

  VIRBase ID:  

VHID00508470

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          MXD4:  NM_006454     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	MXD4
miRBase Accession/Entrez ID	MIMAT0001581	10608
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	bHLHc12//MAD4//MST149//MSTP149

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MXD4	chr4:2249366-2249367(-) m6A 3'UTR       27773536 chr4:2249393-2249394(-) m6A 3'UTR       27773536 chr4:2249400-2249401(-) m6A 3'UTR       27773536 chr4:2249611-2249612(-) m6A 3'UTR       24284625//27773535 chr4:2249623-2249624(-) m6A 3'UTR       24284625//27773535 chr4:2249688-2249689(-) m6A 3'UTR       24284625//27773535 chr4:2250246-2250247(-) m6A 3'UTR       27371828//27773536 chr4:2250406-2250407(-) Y 3'UTR       26075521 chr4:2250663-2250664(-) m6A 3'UTR       24284625//25456834//22608085 chr4:2250682-2250683(-) m6A 3'UTR       24284625//25456834//22608085 chr4:2250688-2250689(-) Y 3'UTR       26075521 chr4:2251021-2251022(-) m6A 3'UTR       24284625 chr4:2251147-2251148(-) m6A 3'UTR       24284625//24981863//22608085 chr4:2251176-2251177(-) m6A 3'UTR       24284625//24981863//22608085 chr4:2251559-2251560(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27371828//27773536//22608085 chr4:2251593-2251594(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27371828//27773536//22608085 chr4:2251623-2251624(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27371828//27773536//22608085 chr4:2251698-2251699(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085 chr4:2251759-2251760(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085 chr4:2251783-2251784(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085 chr4:2251868-2251869(-) m6A 3'UTR//exon       24284625//25456834//24981863//27371828//27773536//22575960//22608085 chr4:2251901-2251902(-) m6A 3'UTR//exon       24284625//25456834//24981863//27371828//27773536//22575960//22608085 chr4:2251952-2251953(-) m6A 3'UTR//exon       24284625//25456834//24981863//22608085 chr4:2252385-2252386(-) m6A 3'UTR//CDS//exon       24284625//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr4:2252421-2252422(-) m6A 3'UTR//CDS//exon       24284625//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr4:2252956-2252957(-) m6A 3'UTR//CDS//exon       24284625//27371828//27773536//22608085 chr4:2252970-2252971(-) m6A 3'UTR//CDS//exon       24284625//27371828//27773536//22608085 chr4:2254239-2254240(-) m6A 3'UTR//CDS//exon       24284625//27773535//27371828//27773536 chr4:2254304-2254305(-) m6A exon//intron       24284625//27773536 chr4:2256592-2256593(-) m6A exon//intron       24284625//24209618//24981863//22608085 chr4:2256624-2256625(-) m6A exon//intron       24284625//24209618//25456834//24981863//22608085 chr4:2256689-2256690(-) m6A exon//intron       24284625//25456834//24981863//27773535//22575960//22608085 chr4:2256722-2256723(-) m6A exon//intron       24284625//25456834//24981863//27773535//22575960//22608085 chr4:2256753-2256754(-) m6A exon//intron       24284625//25456834//24981863//27773535//22575960//22608085 chr4:2256761-2256762(-) m6A exon//intron       24284625//25456834//24981863//27773535//22575960//22608085 chr4:2256815-2256816(-) m6A exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr4:2256928-2256929(-) m6A 3'UTR//exon//intron       24284625//24209618//24981863//27773535//22608085 chr4:2256945-2256946(-) m6A 3'UTR//CDS//exon//intron       24284625//24209618//24981863//27773535//22608085 chr4:2257018-2257019(-) m6A 3'UTR//CDS//exon//intron       24209618//27773535 chr4:2257043-2257044(-) m6A CDS//intron       24209618//27773535//27773536 chr4:2260614-2260615(-) m6A 3'UTR//intron       24209618//27773535//27773536 chr4:2260731-2260732(-) m6A CDS//intron       24209618//27773536 chr4:2263457-2263458(-) m6A CDS//exon       24209618//27773536 chr4:2263491-2263492(-) m6A CDS//exon       24209618//27773536 chr4:2263696-2263697(-) m6A CDS//exon       24209618//27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	MXD4	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: MXD4

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.