Detail Information

Basic Information:


  VIRBase ID:  

VHID00508438

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           SLU7:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p SLU7
miRBase
Accession/Entrez ID		 MIMAT0001581 10569
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - 9G8//hSlu7

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR SLU7
chr5:159843036(-) A-I      intronic
chr5:159842997(-) A-I      intronic
chr5:159829493(-) A-I      3'UTR
chr5:159843037(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED SLU7
chr5:159829421(-) T-G exon 3'UTR    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SLU7
chr5:159828736-159828737(-) m6A 3'UTR       27773535
chr5:159828759-159828760(-) m6A 3'UTR       27773535
chr5:159830125-159830126(-) m6A 3'UTR       27773535
chr5:159830276-159830277(-) m6A 3'UTR//exon       24981863//27773535//22608085
chr5:159830297-159830298(-) m6A CDS//exon       24981863//28052920//27773535//22608085
chr5:159830372-159830373(-) m6A CDS//exon       24981863//28052920//27773535//27371828//22608085
chr5:159830380-159830381(-) m6A CDS//exon       24981863//28052920//27773535//27371828//22608085
chr5:159830428-159830429(-) m6A CDS//exon       24981863//28052920//27773535//27371828//22608085
chr5:159831548-159831549(-) m6A CDS//exon       24981863//28052920//27773535//27371828//22608085
chr5:159831826-159831827(-) m6A CDS       27773535
chr5:159831833-159831834(-) m6A CDS       27773535
chr5:159833456-159833457(-) m6A exon//intron       27773535
chr5:159833462-159833463(-) m6A exon//intron       27773535
chr5:159835671-159835672(-) m6A CDS       27773535
chr5:159835692-159835693(-) m6A CDS       27773535
chr5:159839463-159839464(-) m6A CDS       27773535
chr5:159839499-159839500(-) m6A CDS       27773535
chr5:159839516-159839517(-) m6A CDS       27773535
chr5:159840501-159840502(-) m6A CDS       27773535
chr5:159840573-159840574(-) m6A CDS       27773535
chr5:159840624-159840625(-) m6A CDS       27773535
chr5:159840877-159840878(-) m6A exon//intron       24981863//27773535
chr5:159840915-159840916(-) m6A CDS//exon       24981863//27773535
chr5:159841143-159841144(-) m6A exon//intron       27773535
chr5:159841221-159841222(-) m6A exon//intron       27773535
chr5:159841233-159841234(-) m6A exon//intron       27773535
chr5:159841276-159841277(-) m6A exon//intron       27773535
chr5:159841376-159841377(-) m6A CDS//exon       27773535
chr5:159841391-159841392(-) m6A CDS//exon       27773535
chr5:159841400-159841401(-) m6A CDS//exon       27773535
chr5:159841412-159841413(-) m6A CDS//exon       24981863//27773535
chr5:159841476-159841477(-) m6A CDS//exon       24209618//24981863//27773535
chr5:159842137-159842138(-) m1A CDS//exon       26863196
chr5:159842178-159842179(-) m6A CDS//exon       24284625//24209618//24981863//28052920//27773535//27371828//22608085
chr5:159842192-159842193(-) m1A CDS//exon       26863196//26863410
chr5:159842206-159842207(-) m6A CDS//exon       24284625//24209618//24981863//28052920//27773535//27371828//22608085
chr5:159842229-159842230(-) m6A CDS//exon       24284625//24209618//24981863//28052920//27773535//27371828//22608085
chr5:159844138-159844139(-) m6A 5'UTR//intron       24284625//24209618//24981863//28052920//27773535//27371828//22608085
chr5:159844149-159844150(-) m6A 5'UTR//intron       24284625//24209618//24981863//28052920//27773535//27371828//22608085
chr5:159844185-159844186(-) m6A 5'UTR//intron       24209618//25456834//24981863//27773535//27371828//22608085
chr5:159845609-159845610(-) m6A 5'UTR//exon//intron       24981863
chr5:159845818-159845819(-) m6A 5'UTR//intron       27773535
chr5:159845870-159845871(-) m6A 5'UTR//intron       27773535
chr5:159845892-159845893(-) m6A 5'UTR//intron       27773535
chr5:159845983-159845984(-) m6A 5'UTR//intron       24981863
chr5:159846009-159846010(-) m6A 5'UTR//intron       24981863
chr5:159846055-159846056(-) m6A 5'UTR//exon//intron       24981863
chr5:159846089-159846090(-) m6A 5'UTR//intron       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate SLU7
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: SLU7

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

Starting a new search, please wait ...