Detail Information

Basic Information:


  VIRBase ID:  

VHID00508417

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           TM9SF1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p TM9SF1
miRBase
Accession/Entrez ID		 MIMAT0001581 10548
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - HMP70//MP70

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TM9SF1
chr14:24662646(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TM9SF1
chr14:24658566-24658567(-) m6A 3'UTR       24284625//24981863//22608085
chr14:24658604-24658605(-) m6A 3'UTR       24284625//24981863//22608085
chr14:24658624-24658625(-) m6A 3'UTR//CDS       24284625//24981863//22608085
chr14:24659430-24659431(-) m6A 3'UTR//intron       24981863
chr14:24659666-24659667(-) m6A 3'UTR//CDS//intron       24284625//27773535
chr14:24659705-24659706(-) m6A CDS//intron       24284625//27773535
chr14:24661005-24661006(-) m6A exon//intron       24284625
chr14:24661017-24661018(-) m6A exon//intron       24284625
chr14:24661040-24661041(-) m6A exon//intron       24284625//27773535
chr14:24661210-24661211(-) m6A exon//intron       27773535
chr14:24661223-24661224(-) m6A exon//intron       24284625//27773535
chr14:24661233-24661234(-) m6A exon//intron       24284625//27773535
chr14:24661271-24661272(-) m6A exon//intron       24284625//24981863//27773535//22608085
chr14:24661325-24661326(-) m6A exon//intron       24284625//24981863//27773535
chr14:24661340-24661341(-) m6A exon//intron       24284625//27773535
chr14:24661369-24661370(-) m6A exon//intron       24284625//27773535
chr14:24661405-24661406(-) m6A CDS//exon//intron       24284625
chr14:24662000-24662001(-) m6A CDS//exon//intron       24284625//24209618//24981863//27773535//22575960//22608085
chr14:24662129-24662130(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr14:24662189-24662190(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr14:24662305-24662306(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr14:24662329-24662330(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr14:24662339-24662340(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr14:24662346-24662347(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr14:24662445-24662446(-) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr14:24663968-24663969(-) m6A 5'UTR//CDS//intron       24284625//24209618//26404942//27773535//22575960//22608085
chr14:24664053-24664054(-) m6A CDS//intron       24284625//24209618//26404942//27773535//22575960
chr14:24664075-24664076(-) m6A CDS//intron       24284625//24209618//26404942//27773535//22575960
chr14:24664208-24664209(-) m6A CDS//intron       24284625//27773535//27371828
chr14:24664245-24664246(-) m6A 5'UTR//intron       27773535//27371828
chr14:24664317-24664318(-) m6A 5'UTR//intron       27773536
chr14:24664506-24664507(-) m6A 5'UTR//intron       27773536
chr14:24664520-24664521(-) m6A 5'UTR//intron       27773536
chr14:24664544-24664545(-) m6A 5'UTR//intron       24981863//27773536
chr14:24664626-24664627(-) m6A 5'UTR//intron       24981863//26404942//27773536
chr14:24664856-24664857(-) m6A 5'UTR       27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate TM9SF1
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleus HCC cell line (HepG2)|K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: TM9SF1

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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