Basic Information:

  VIRBase ID:  

VHID00508281

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          TUBB3:  NM_006086     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	TUBB3
miRBase Accession/Entrez ID	MIMAT0001581	10381
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	beta-4//CDCBM//CDCBM1//CFEOM3//CFEOM3A//FEOM3//TUBB4

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TUBB3	chr16:89999378(+) A-I      intronic chr16:89993039(+) A-I      intronic chr16:89994653(+) A-I      intronic chr16:89993377(+) A-I      intronic chr16:89993230(+) A-I      intronic chr16:89991961(+) A-I      intronic chr16:89993732(+) A-I      intronic chr16:89995510(+) A-I      intronic chr16:89993544(+) A-I      intronic chr16:89995560(+) A-I      intronic chr16:89993386(+) A-I      intronic chr16:89996190(+) A-I      intronic chr16:89995497(+) A-I      intronic chr16:89995593(+) A-I      intronic chr16:89995451(+) A-I      intronic chr16:89991847(+) A-I      intronic chr16:89993780(+) A-I      intronic chr16:89994563(+) A-I      intronic chr16:89993550(+) A-I      intronic chr16:89993265(+) A-I      intronic chr16:89993725(+) A-I      intronic chr16:89994847(+) A-I      intronic chr16:89994871(+) A-I      intronic chr16:89994726(+) A-I      intronic chr16:89993748(+) A-I      intronic chr16:89993310(+) A-I      intronic chr16:89993644(+) A-I      intronic chr16:89991798(+) A-I      intronic chr16:89994504(+) A-I      intronic chr16:89995606(+) A-I      intronic chr16:89991745(+) A-I      intronic chr16:89991883(+) A-I      intronic chr16:89995551(+) A-I      intronic chr16:89991946(+) A-I      intronic chr16:89994543(+) A-I      intronic chr16:89993781(+) A-I      intronic chr16:89993387(+) A-I      intronic chr16:89996248(+) A-I      intronic chr16:89991979(+) A-I      intronic chr16:89995501(+) A-I      intronic chr16:89993144(+) A-I      intronic chr16:89992377(+) A-I      intronic chr16:89991768(+) A-I      intronic chr16:89991799(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TUBB3	chr16:89988302-89988303(+) m6A 5'UTR//intron       24981863 chr16:89988337-89988338(+) m6A 5'UTR//intron       24284625//24981863 chr16:89988383-89988384(+) m6A 5'UTR//intron       24284625//24209618//24981863 chr16:89988401-89988402(+) m6A 5'UTR//intron       24284625//24209618//24981863 chr16:89988418-89988419(+) m6A 5'UTR//intron       24284625//24209618//24981863 chr16:89988431-89988432(+) m6A 5'UTR//intron       24284625//24209618//24981863 chr16:89988441-89988442(+) m6A 5'UTR//intron       24284625//24209618//24981863 chr16:89988447-89988448(+) m6A 5'UTR//intron       24284625//24209618//24981863 chr16:89988457-89988458(+) m6A 5'UTR//intron       24284625//24209618//24981863 chr16:89988472-89988473(+) m6A 5'UTR//intron       24284625//24209618//24981863 chr16:89988528-89988529(+) m6A 5'UTR//intron       24284625//24981863 chr16:89988556-89988557(+) m6A 5'UTR//intron       24981863 chr16:89996852-89996853(+) m6A intron       24284625//25456834//24981863 chr16:89998094-89998095(+) m6A exon//intron       - chr16:89998102-89998103(+) m6A exon//intron       - chr16:89998413-89998414(+) m6A exon//intron       - chr16:89998479-89998480(+) m6A exon//intron       - chr16:89999042-89999043(+) m6A 3'UTR//5'UTR//CDS//exon       24284625 chr16:89999124-89999125(+) m6A exon//intron       - chr16:89999690-89999691(+) m6A 3'UTR//intron       - chr16:89999744-89999745(+) m6A 3'UTR//intron       - chr16:89999908-89999909(+) m6A 3'UTR//5'UTR//CDS       24284625 chr16:89999915-89999916(+) m6A 3'UTR//5'UTR//CDS       24284625 chr16:89999922-89999923(+) m6A 3'UTR//5'UTR//CDS       24284625 chr16:89999929-89999930(+) m6A 3'UTR//CDS       24284625 chr16:89999954-89999955(+) m6A 3'UTR//CDS       24284625 chr16:90000019-90000020(+) m6A CDS//intron       24284625 chr16:90000068-90000069(+) m6A CDS//intron       24284625 chr16:90000216-90000217(+) m6A 3'UTR//intron       25456834//24981863 chr16:90000251-90000252(+) m6A 3'UTR//intron       25456834//24981863 chr16:90000272-90000273(+) m6A 3'UTR//intron       25456834//24981863 chr16:90001235-90001236(+) m6A 3'UTR//CDS//intron       24284625//24981863 chr16:90001352-90001353(+) m6A 3'UTR//CDS//intron       24284625//24981863 chr16:90001388-90001389(+) m6A 3'UTR//CDS//intron       24284625//24981863//22575960 chr16:90001442-90001443(+) m6A 3'UTR//CDS//intron       24284625//24981863//22575960 chr16:90001453-90001454(+) m6A 3'UTR//CDS//intron       24284625//24981863//22575960 chr16:90001529-90001530(+) m6A 3'UTR//CDS//intron       24284625//24981863//22575960 chr16:90001751-90001752(+) m6A 3'UTR//CDS//intron       24284625//22608085 chr16:90001868-90001869(+) m6A 3'UTR//CDS//intron       24284625//24981863//22608085 chr16:90001967-90001968(+) m6A 3'UTR//CDS//intron       24284625 chr16:90001990-90001991(+) Y 3'UTR//CDS//intron       26075521 chr16:90002273-90002274(+) m6A 3'UTR//intron       - chr16:90002399-90002400(+) Y 3'UTR//intron       26075521

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	TUBB3	Chromatin K562 cells     - Exosome Blood     - Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: TUBB3

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.