Basic Information:

  VIRBase ID:  

VHID00508263

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          ABCA7:  NM_019112     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	ABCA7
miRBase Accession/Entrez ID	MIMAT0001581	10347
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	ABCA-SSN//ABCX//AD9

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ABCA7	chr19:1061587(+) A-I      intronic chr19:1059692(+) A-I      intronic chr19:1061567(+) A-I      intronic chr19:1061599(+) A-I      intronic chr19:1061542(+) A-I      intronic chr19:1061559(+) A-I      intronic chr19:1060372(+) A-I      intronic chr19:1059516(+) A-I      intronic chr19:1059746(+) A-I      intronic chr19:1059765(+) A-I      intronic chr19:1059768(+) A-I      intronic chr19:1059772(+) A-I      intronic chr19:1060311(+) A-I      intronic chr19:1060328(+) A-I      intronic chr19:1061134(+) A-I      intronic chr19:1061162(+) A-I      intronic chr19:1061170(+) A-I      intronic chr19:1061181(+) A-I      intronic chr19:1061265(+) A-I      intronic chr19:1061467(+) A-I      intronic chr19:1061507(+) A-I      intronic chr19:1061508(+) A-I      intronic chr19:1061518(+) A-I      intronic chr19:1061551(+) A-I      intronic chr19:1061212(+) A-I      intronic chr19:1061610(+) A-I      intronic chr19:1061630(+) A-I      intronic chr19:1059381(+) A-I      intronic chr19:1059393(+) A-I      intronic chr19:1060352(+) A-I      intronic chr19:1059664(+) A-I      intronic chr19:1059728(+) A-I      intronic chr19:1059729(+) A-I      intronic chr19:1059737(+) A-I      intronic chr19:1050381(+) A-I      intronic chr19:1059640(+) A-I      intronic chr19:1061140(+) A-I      intronic chr19:1061647(+) A-I      intronic chr19:1061275(+) A-I      intronic chr19:1061377(+) A-I      intronic chr19:1061454(+) A-I      intronic chr19:1059813(+) A-I      intronic chr19:1059580(+) A-I      intronic chr19:1061186(+) A-I      intronic chr19:1061234(+) A-I      intronic chr19:1060304(+) A-I      intronic chr19:1059680(+) A-I      intronic chr19:1059835(+) A-I      intronic chr19:1059699(+) A-I      intronic chr19:1061321(+) A-I      intronic chr19:1059643(+) A-I      intronic chr19:1061249(+) A-I      intronic chr19:1059471(+) A-I      intronic chr19:1061231(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ABCA7	chr19:1061210(+) A-G intron -    22484847 chr19:1061231(+) A-G intron -    22484847 chr19:1061234(+) A-G intron -    22484847 chr19:1061245(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ABCA7	chr19:1041234-1041235(+) m6A 5'UTR//exon//intron       24284625 chr19:1041419-1041420(+) m6A CDS//exon       24284625 chr19:1043238-1043239(+) m6A CDS       - chr19:1043365-1043366(+) m6A CDS       - chr19:1045110-1045111(+) m6A CDS       - chr19:1045118-1045119(+) m6A CDS       - chr19:1045127-1045128(+) m6A CDS       - chr19:1054795-1054796(+) m6A 3'UTR//CDS       - chr19:1065138-1065139(+) m6A CDS//exon       24284625//22575960 chr19:1065290-1065291(+) m6A CDS//exon       24284625//25456834//22575960 chr19:1065308-1065309(+) m6A CDS//exon       24284625//25456834//22575960//22608085 chr19:1065344-1065345(+) m6A CDS//exon       24284625//25456834//24981863//22575960//22608085 chr19:1065412-1065413(+) m6A CDS//exon       24284625//25456834//24981863//22575960//22608085 chr19:1065498-1065499(+) m6A 3'UTR//exon       24284625//25456834//24981863//22575960//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ABCA7	Chromatin K562 cells     - Cytosol K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Plasma     23663360 Exosome Blood     - Insoluble cytoplasm K562 cells     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: ABCA7

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.