Basic Information:

  VIRBase ID:  

VHID00508258

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          TFG:  NM_001195479     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	TFG
miRBase Accession/Entrez ID	MIMAT0001581	10342
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	HMSNP//SPG57//TF6//TRKT3

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TFG	chr3:100433283(+) A-I      intronic chr3:100446748(+) A-I      intronic chr3:100433224(+) A-I      intronic chr3:100433231(+) A-I      intronic chr3:100433225(+) A-I      intronic chr3:100433194(+) A-I      intronic chr3:100432798(+) A-I      intronic chr3:100432788(+) A-I      intronic chr3:100446806(+) A-I      intronic chr3:100433251(+) A-I      intronic chr3:100433265(+) A-I      intronic chr3:100440852(+) A-I      intronic chr3:100443767(+) A-I      intronic chr3:100443957(+) A-I      intronic chr3:100444367(+) A-I      intronic chr3:100444437(+) A-I      intronic chr3:100444523(+) A-I      intronic chr3:100444024(+) A-I      intronic chr3:100443817(+) A-I      intronic chr3:100444391(+) A-I      intronic chr3:100444558(+) A-I      intronic chr3:100444518(+) A-I      intronic chr3:100443822(+) A-I      intronic chr3:100432819(+) A-I      intronic chr3:100443877(+) A-I      intronic chr3:100432814(+) A-I      intronic chr3:100440858(+) A-I      intronic chr3:100450478(+) A-I      intronic chr3:100450501(+) A-I      intronic chr3:100443860(+) A-I      intronic chr3:100444519(+) A-I      intronic chr3:100444502(+) A-I      intronic chr3:100444403(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	TFG	chr3:100432814(+) A-G intron -    22484847 chr3:100432819(+) A-G intron -    22484847 chr3:100433080(+) A-G intron -    22484847 chr3:100433088(+) A-G intron -    22484847 chr3:100433244(+) A-C intron -    22484847 chr3:100440816(+) A-G intron -    22484847 chr3:100440858(+) A-G intron -    22484847 chr3:100443817(+) A-G intron -    22484847 chr3:100443822(+) A-G intron -    22484847 chr3:100443860(+) A-G intron -    22484847 chr3:100443877(+) A-G intron -    22484847 chr3:100443887(+) A-G intron -    22484847 chr3:100443932(+) A-G intron -    22484847 chr3:100444391(+) A-G intron -    22484847 chr3:100444403(+) A-G intron -    22484847 chr3:100444520(+) T-C intron -    22484847 chr3:100458749(+) T-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TFG	chr3:100428208-100428209(+) m6A 5'UTR       24981863 chr3:100428231-100428232(+) m6A 5'UTR       24981863 chr3:100428308-100428309(+) m6A 5'UTR//intron       24981863 chr3:100428527-100428528(+) m6A 5'UTR//intron       24981863//22575960 chr3:100428618-100428619(+) m6A 5'UTR//intron       24981863 chr3:100432512-100432513(+) m6A 5'UTR       26404942 chr3:100432537-100432538(+) m6A CDS       26404942 chr3:100451453-100451454(+) m6A CDS       27773535 chr3:100455454-100455455(+) m6A CDS       27773535 chr3:100455538-100455539(+) m6A CDS       24981863//26404942//27773535 chr3:100461353-100461354(+) m6A exon//intron       24284625//24981863 chr3:100461423-100461424(+) m6A exon//intron       24284625 chr3:100463635-100463636(+) m6A exon//intron       24981863 chr3:100467009-100467010(+) m6A 3'UTR//CDS//exon       24284625//24981863 chr3:100467014-100467015(+) m6A 3'UTR//CDS//exon       24284625//24981863 chr3:100467153-100467154(+) m6A 3'UTR//CDS//exon       24284625//24981863//26404942//27773535 chr3:100467168-100467169(+) m6A 3'UTR//CDS//exon       24284625//24981863//26404942//27773535 chr3:100467251-100467252(+) m6A 3'UTR//CDS//exon       24284625//24981863//26404942//27773535 chr3:100467359-100467360(+) m6A 3'UTR//CDS//exon       24284625//24981863//27773535 chr3:100467428-100467429(+) m6A 3'UTR//exon       24284625//24981863//26404942//27773535 chr3:100467533-100467534(+) m6A 3'UTR//exon       26404942//27773535 chr3:100467541-100467542(+) m6A 3'UTR//exon       26404942//27773535 chr3:100467602-100467603(+) m6A 3'UTR//exon       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	TFG	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: TFG

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.