Detail Information

Basic Information:


  VIRBase ID:  

VHID00508255

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           TLR6:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p TLR6
miRBase
Accession/Entrez ID		 MIMAT0001581 10333
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - CD286

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TLR6
chr4:38846503(-) A-I      intronic
chr4:38846431(-) A-I      intronic
chr4:38842253(-) A-I      intronic
chr4:38842251(-) A-I      intronic
chr4:38846430(-) A-I      intronic
chr4:38842147(-) A-I      intronic
chr4:38826713(-) A-I      3'UTR
chr4:38826693(-) A-I      3'UTR
chr4:38826424(-) A-I      3'UTR
chr4:38826525(-) A-I      3'UTR
chr4:38826697(-) A-I      3'UTR
chr4:38826515(-) A-I      3'UTR
chr4:38826690(-) A-I      3'UTR
chr4:38826514(-) A-I      3'UTR
chr4:38847549(-) A-I      intronic
chr4:38847613(-) A-I      intronic
chr4:38847556(-) A-I      intronic
chr4:38846604(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED TLR6
chr4:38826544(-) T-C exon 3'UTR    22484847
chr4:38826693(-) A-G exon 3'UTR    22484847
chr4:38826697(-) A-G exon 3'UTR    22484847
chr4:38826713(-) A-G exon 3'UTR    22484847
chr4:38826715(-) C-T exon 3'UTR    22484847
chr4:38842147(-) A-G intron -    22484847
chr4:38846604(-) A-G intron -    22484847
chr4:38847556(-) A-G intron -    22484847
chr4:38847631(-) A-G intron -    22484847
chr4:38847729(-) C-T intron -    22484847
chr4:38847734(-) C-T intron -    22484847
chr4:38856832(-) G-T intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TLR6
chr4:38825877-38825878(-) m6A 3'UTR       24981863
chr4:38825969-38825970(-) m6A 3'UTR       24981863
chr4:38826175-38826176(-) m6A 3'UTR       24981863//27773535
chr4:38826205-38826206(-) m6A 3'UTR       24981863//27773535
chr4:38826212-38826213(-) m6A 3'UTR       24981863//27773535
chr4:38826221-38826222(-) m6A 3'UTR       24981863//27773535
chr4:38826240-38826241(-) m6A 3'UTR       24981863//27773535
chr4:38826253-38826254(-) m6A 3'UTR       24981863//27773535
chr4:38826317-38826318(-) m6A 3'UTR       27773535
chr4:38826725-38826726(-) m6A 3'UTR       24209618//24981863//27773535
chr4:38826743-38826744(-) m6A 3'UTR       24209618//24981863//27773535
chr4:38826793-38826794(-) m6A 3'UTR       24284625//24209618//24981863//27773535
chr4:38826902-38826903(-) m6A 3'UTR       24284625//24209618//24981863//27773535
chr4:38826912-38826913(-) m6A 3'UTR       24284625//24209618//24981863//27773535
chr4:38826994-38826995(-) m6A 3'UTR       24284625//24209618//24981863//27773535
chr4:38827016-38827017(-) m6A 3'UTR       24284625//24209618//24981863//27773535
chr4:38827022-38827023(-) m6A 3'UTR       24284625//24209618//24981863//27773535
chr4:38827042-38827043(-) m6A 3'UTR       24284625//24209618//24981863//27773535
chr4:38827158-38827159(-) m6A 3'UTR       24284625//24209618//24981863//27773535
chr4:38827232-38827233(-) m6A 3'UTR       24284625//24981863//27773535
chr4:38827313-38827314(-) m6A 3'UTR       24284625//24981863//27773535
chr4:38827330-38827331(-) m6A 3'UTR       24284625//24981863//27773535
chr4:38827610-38827611(-) m6A 3'UTR       24284625//24209618//24981863//27773535
chr4:38827618-38827619(-) m6A 3'UTR       24284625//24209618//24981863//27773535
chr4:38827737-38827738(-) m6A 3'UTR       24284625//24209618//24981863//27773535
chr4:38827777-38827778(-) m6A 3'UTR       24284625//24209618//24981863//27773535
chr4:38827790-38827791(-) m6A 3'UTR       24284625//24209618//24981863//27773535
chr4:38827869-38827870(-) m6A 3'UTR       24284625//24209618//24981863//28052920//27773535//22575960//22608085
chr4:38827907-38827908(-) m6A 3'UTR       24284625//24209618//24981863//28052920//27773535//27371828//22575960//22608085
chr4:38827930-38827931(-) m6A 3'UTR       24284625//24209618//24981863//28052920//27773535//27371828//22575960//22608085
chr4:38827945-38827946(-) m6A 3'UTR       24284625//24209618//24981863//28052920//27773535//27371828//22575960//22608085
chr4:38827972-38827973(-) m6A 3'UTR       24284625//24209618//24981863//28052920//27773535//27371828//22575960//22608085
chr4:38828023-38828024(-) m6A 3'UTR       24284625//24209618//24981863//28052920//27773535//27371828//22575960//22608085
chr4:38828061-38828062(-) m6A 3'UTR       24284625//24209618//24981863//28052920//27773535//27371828//22575960//22608085
chr4:38828116-38828117(-) m6A 3'UTR       24284625//24209618//24981863//28052920//27773535//22608085
chr4:38828157-38828158(-) m6A 3'UTR       24284625//24209618//24981863//28052920//27773535//22608085
chr4:38828369-38828370(-) m6A 3'UTR       24209618//24981863
chr4:38828477-38828478(-) m6A 3'UTR       24284625//24209618//24981863//27773535
chr4:38828521-38828522(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960
chr4:38828558-38828559(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960
chr4:38828577-38828578(-) m6A 3'UTR       24284625//24209618//24981863//28052920//27773535//22575960
chr4:38828588-38828589(-) m6A 3'UTR       24284625//24209618//24981863//28052920//27773535//22575960
chr4:38828675-38828676(-) m6A 3'UTR       24284625//24209618//24981863//28052920//27773535//22575960//22608085
chr4:38828722-38828723(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//22575960//22608085
chr4:38828819-38828820(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//22575960//22608085
chr4:38828869-38828870(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//22575960//22608085
chr4:38828883-38828884(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//22575960//22608085
chr4:38828949-38828950(-) m6A CDS       24284625//24209618//24981863//27773535//22575960
chr4:38829064-38829065(-) m6A CDS//intron       24284625//24981863
chr4:38829144-38829145(-) m6A CDS//intron       24284625//24981863
chr4:38829178-38829179(-) m6A CDS//intron       24981863
chr4:38829189-38829190(-) m6A CDS//intron       24981863
chr4:38829205-38829206(-) m6A CDS//intron       24981863
chr4:38829224-38829225(-) m6A CDS//intron       24981863
chr4:38829230-38829231(-) m6A CDS//intron       24981863
chr4:38829373-38829374(-) m6A CDS//intron       24284625//24209618//24981863//27773535
chr4:38829460-38829461(-) m6A CDS//intron       24284625//24981863//27773535
chr4:38829511-38829512(-) m6A CDS//intron       24284625//24981863//27773535
chr4:38829663-38829664(-) m6A CDS//intron       24981863
chr4:38829681-38829682(-) m6A CDS//intron       24981863
chr4:38829693-38829694(-) m6A CDS//intron       24981863
chr4:38829826-38829827(-) m6A CDS//intron       24981863//27773535
chr4:38829837-38829838(-) m6A CDS//intron       24981863//27773535
chr4:38829922-38829923(-) m6A CDS//intron       24981863//26404942//27773535//22608085
chr4:38829953-38829954(-) m6A CDS       24981863//26404942//22608085
chr4:38830018-38830019(-) m6A CDS       24981863//27773535
chr4:38830099-38830100(-) m6A CDS       24981863//27773535
chr4:38830130-38830131(-) m6A CDS       24981863//27773535
chr4:38830153-38830154(-) m6A CDS       24981863
chr4:38830164-38830165(-) m6A CDS       24981863
chr4:38830266-38830267(-) m6A CDS       24981863//27773535
chr4:38830362-38830363(-) m6A CDS       24284625//24981863
chr4:38830453-38830454(-) m6A CDS       24981863
chr4:38830502-38830503(-) m6A CDS       24981863
chr4:38830848-38830849(-) m6A CDS       24981863
chr4:38830909-38830910(-) m6A CDS       24981863//27773535
chr4:38830934-38830935(-) m6A CDS       24284625//24981863//27773535
chr4:38830948-38830949(-) m6A CDS       24284625//24981863//27773535
chr4:38830984-38830985(-) m6A CDS       24284625//24981863//27773535
chr4:38831024-38831025(-) m6A CDS       24284625//24981863//27773535
chr4:38831076-38831077(-) m6A CDS       24284625//24981863//27773535
chr4:38831083-38831084(-) m6A CDS       24284625//24981863//27773535
chr4:38831123-38831124(-) m6A 5'UTR       24981863//27773535
chr4:38831150-38831151(-) m6A 5'UTR       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate TLR6
Exosome Blood     -

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: TLR6

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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