Detail Information

Basic Information:


  VIRBase ID:  

VHID00508241

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7903

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           TNIP1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p TNIP1
miRBase
Accession/Entrez ID		 MIMAT0001581 10318
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - ABIN-1//NAF1//nip40-1//VAN

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TNIP1
chr5:150417783(-) A-I      intronic
chr5:150437043(-) A-I      intronic
chr5:150454512(-) A-I      intronic
chr5:150441314(-) A-I      intronic
chr5:150432935(-) A-I      intronic
chr5:150423214(-) A-I      intronic
chr5:150452700(-) A-I      intronic
chr5:150432848(-) A-I      intronic
chr5:150452706(-) A-I      intronic
chr5:150423870(-) A-I      intronic
chr5:150454508(-) A-I      intronic
chr5:150433998(-) A-I      intronic
chr5:150454517(-) A-I      intronic
chr5:150423236(-) A-I      intronic
chr5:150432844(-) A-I      intronic
chr5:150423106(-) A-I      intronic
chr5:150423124(-) A-I      intronic
chr5:150423132(-) A-I      intronic
chr5:150423170(-) A-I      intronic
chr5:150423212(-) A-I      intronic
chr5:150454467(-) A-I      intronic
chr5:150432917(-) A-I      intronic
chr5:150437657(-) A-I      intronic
chr5:150432815(-) A-I      intronic
chr5:150423254(-) A-I      intronic
chr5:150423259(-) A-I      intronic
chr5:150423310(-) A-I      intronic
chr5:150423753(-) A-I      intronic
chr5:150423799(-) A-I      intronic
chr5:150423849(-) A-I      intronic
chr5:150423898(-) A-I      intronic
chr5:150424729(-) A-I      intronic
chr5:150424749(-) A-I      intronic
chr5:150424824(-) A-I      intronic
chr5:150424828(-) A-I      intronic
chr5:150434096(-) A-I      intronic
chr5:150434120(-) A-I      intronic
chr5:150437064(-) A-I      intronic
chr5:150437170(-) A-I      intronic
chr5:150437754(-) A-I      intronic
chr5:150432767(-) A-I      intronic
chr5:150423201(-) A-I      intronic
chr5:150423115(-) A-I      intronic
chr5:150433985(-) A-I      intronic
chr5:150437777(-) A-I      intronic
chr5:150434025(-) A-I      intronic
chr5:150437661(-) A-I      intronic
chr5:150453361(-) A-I      intronic
chr5:150437115(-) A-I      intronic
chr5:150423672(-) A-I      intronic
chr5:150423758(-) A-I      intronic
chr5:150424788(-) A-I      intronic
chr5:150454503(-) A-I      intronic
chr5:150437129(-) A-I      intronic
chr5:150423118(-) A-I      intronic
chr5:150424844(-) A-I      intronic
chr5:150434007(-) A-I      intronic
chr5:150433997(-) A-I      intronic
chr5:150423335(-) A-I      intronic
chr5:150432809(-) A-I      intronic
chr5:150432846(-) A-I      intronic
chr5:150454507(-) A-I      intronic
chr5:150437658(-) A-I      intronic
chr5:150454422(-) A-I      intronic
chr5:150437194(-) A-I      intronic
chr5:150454412(-) A-I      intronic
chr5:150423219(-) A-I      intronic
chr5:150423073(-) A-I      intronic
chr5:150433963(-) A-I      intronic
chr5:150432819(-) A-I      intronic
chr5:150437655(-) A-I      intronic
chr5:150424883(-) A-I      intronic
chr5:150437215(-) A-I      intronic
chr5:150454477(-) A-I      intronic
chr5:150437619(-) A-I      intronic
chr5:150423187(-) A-I      intronic
chr5:150423654(-) A-I      intronic
chr5:150423298(-) A-I      intronic
chr5:150424826(-) A-I      intronic
chr5:150434122(-) A-I      intronic
chr5:150437178(-) A-I      intronic
chr5:150423882(-) A-I      intronic
chr5:150434070(-) A-I      intronic
chr5:150454585(-) A-I      intronic
chr5:150424736(-) A-I      intronic
chr5:150423875(-) A-I      intronic
chr5:150434024(-) A-I      intronic
chr5:150452566(-) A-I      intronic
chr5:150434149(-) A-I      intronic
chr5:150452591(-) A-I      intronic
chr5:150437112(-) A-I      intronic
chr5:150434127(-) A-I      intronic
chr5:150423289(-) A-I      intronic
chr5:150423267(-) A-I      intronic
chr5:150434076(-) A-I      intronic
chr5:150423735(-) A-I      intronic
chr5:150423151(-) A-I      intronic
chr5:150437121(-) A-I      intronic
chr5:150434085(-) A-I      intronic
chr5:150432847(-) A-I      intronic
chr5:150437620(-) A-I      intronic
chr5:150423114(-) A-I      intronic
chr5:150437659(-) A-I      intronic
chr5:150434180(-) A-I      intronic
chr5:150423845(-) A-I      intronic
chr5:150453360(-) A-I      intronic
chr5:150434188(-) A-I      intronic
chr5:150452736(-) A-I      intronic
chr5:150454455(-) A-I      intronic
chr5:150432944(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED TNIP1
chr5:150423224(-) A-I intron -    22327324
chr5:150423305(-) A-I intron -    22327324
chr5:150423802(-) A-I intron -    22327324
chr5:150423882(-) A-I intron -    22327324
chr5:150413045(-) G-C intron -    21725310
chr5:150412688(-) G-T intron -    22484847
chr5:150423073(-) A-G intron -    22484847
chr5:150423092(-) G-A intron -    22484847
chr5:150423115(-) A-G intron -    22484847
chr5:150423118(-) A-G intron -    22484847
chr5:150423151(-) A-G intron -    22484847
chr5:150423153(-) A-G intron -    22484847
chr5:150423217(-) A-G intron -    22484847
chr5:150423219(-) A-G intron -    22484847
chr5:150423267(-) A-G intron -    22484847
chr5:150423274(-) A-G intron -    22484847
chr5:150423289(-) A-G intron -    22484847
chr5:150423298(-) A-G intron -    22484847
chr5:150423305(-) A-G intron -    22484847
chr5:150423335(-) A-G intron -    22484847
chr5:150423336(-) A-G intron -    22484847
chr5:150423672(-) A-G intron -    22484847
chr5:150423735(-) A-G intron -    22484847
chr5:150423758(-) A-G intron -    22484847
chr5:150423798(-) A-G intron -    22484847
chr5:150423802(-) A-G intron -    22484847
chr5:150423804(-) A-G intron -    22484847
chr5:150423840(-) A-G intron -    22484847
chr5:150423875(-) A-G intron -    22484847
chr5:150423882(-) A-G intron -    22484847
chr5:150424736(-) A-G intron -    22484847
chr5:150424742(-) A-G intron -    22484847
chr5:150424788(-) A-G intron -    22484847
chr5:150424844(-) A-G intron -    22484847
chr5:150424852(-) A-G intron -    22484847
chr5:150432767(-) A-G intron -    22484847
chr5:150432809(-) A-G intron -    22484847
chr5:150432831(-) A-G intron -    22484847
chr5:150433963(-) A-G intron -    22484847
chr5:150433985(-) A-G intron -    22484847
chr5:150433997(-) A-G intron -    22484847
chr5:150434007(-) A-G intron -    22484847
chr5:150434024(-) A-G intron -    22484847
chr5:150434025(-) A-G intron -    22484847
chr5:150434050(-) A-G intron -    22484847
chr5:150434070(-) A-G intron -    22484847
chr5:150434076(-) A-G intron -    22484847
chr5:150434085(-) A-G intron -    22484847
chr5:150434116(-) A-G intron -    22484847
chr5:150434122(-) A-G intron -    22484847
chr5:150434180(-) A-G intron -    22484847
chr5:150437112(-) A-G intron -    22484847
chr5:150437115(-) A-G intron -    22484847
chr5:150437121(-) A-G intron -    22484847
chr5:150437129(-) A-G intron -    22484847
chr5:150437130(-) A-G intron -    22484847
chr5:150437178(-) A-G intron -    22484847
chr5:150437194(-) A-G intron -    22484847
chr5:150437584(-) G-A intron -    22484847
chr5:150437591(-) G-A intron -    22484847
chr5:150437606(-) A-G intron -    22484847
chr5:150437619(-) A-G intron -    22484847
chr5:150437620(-) A-G intron -    22484847
chr5:150437651(-) A-G intron -    22484847
chr5:150437655(-) A-G intron -    22484847
chr5:150437658(-) A-G intron -    22484847
chr5:150437659(-) A-G intron -    22484847
chr5:150437660(-) A-G intron -    22484847
chr5:150437661(-) A-G intron -    22484847
chr5:150437777(-) A-G intron -    22484847
chr5:150441057(-) T-A intron -    22484847
chr5:150452566(-) A-G intron -    22484847
chr5:150452591(-) A-G intron -    22484847
chr5:150452671(-) A-G intron -    22484847
chr5:150452697(-) G-A intron -    22484847
chr5:150452745(-) T-A intron -    22484847
chr5:150452787(-) C-T intron -    22484847
chr5:150453360(-) A-G intron -    22484847
chr5:150453361(-) A-G intron -    22484847
chr5:150454422(-) A-G intron -    22484847
chr5:150454441(-) A-G intron -    22484847
chr5:150454477(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TNIP1
chr5:150409531-150409532(-) m6A 3'UTR       24981863//28052920//27773535//22608085
chr5:150409615-150409616(-) m6A 3'UTR       24284625//24981863//28052920//27773535//22608085
chr5:150409622-150409623(-) m6A 3'UTR       24284625//24981863//28052920//27773535//22608085
chr5:150409772-150409773(-) m6A 3'UTR//intron       24284625//24981863//26404942
chr5:150409837-150409838(-) m6A 3'UTR//intron       24284625//24981863//26404942
chr5:150409922-150409923(-) m6A 3'UTR//intron       24284625//25456834//24981863//27371828//22608085
chr5:150409938-150409939(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//28052920//27371828//22575960//22608085
chr5:150410044-150410045(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr5:150410104-150410105(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27371828//22608085
chr5:150410121-150410122(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27371828//22608085
chr5:150410206-150410207(-) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27371828//22608085
chr5:150410271-150410272(-) m6A 3'UTR//CDS//exon//intron       24284625//24981863//27371828
chr5:150411669-150411670(-) m6A exon//intron       24284625
chr5:150411851-150411852(-) m6A 3'UTR//CDS//exon//intron       27773535
chr5:150411876-150411877(-) m6A 3'UTR//CDS//exon//intron       24284625//27773535
chr5:150412223-150412224(-) m6A exon//intron       27773535
chr5:150412285-150412286(-) m6A exon//intron       27773535
chr5:150412297-150412298(-) m6A exon//intron       27773535
chr5:150413077-150413078(-) m6A 3'UTR//intron       24209618
chr5:150413116-150413117(-) m6A CDS//intron       24209618
chr5:150413250-150413251(-) m6A CDS//exon//intron       24284625//24209618//27773535//27371828
chr5:150413321-150413322(-) m6A CDS//exon//intron       24284625//24209618//28052920//27773535//27371828
chr5:150414583-150414584(-) m6A CDS//exon//intron       24284625//24209618//24981863//28052920//27773535//27371828
chr5:150415189-150415190(-) m1A CDS//exon//intron       26863196
chr5:150415207-150415208(-) Gm CDS//exon//intron       -
chr5:150415248-150415249(-) m6A CDS//exon//intron       24284625//24209618//24981863//28052920//26404942//27773535//27371828//27773536//22575960
chr5:150416356-150416357(-) m6A CDS//exon//intron       24284625//24209618//24981863//28052920//26404942//27773535//27371828//27773536//22575960
chr5:150416389-150416390(-) m6A CDS//exon//intron       24284625//24209618//24981863//26404942//27773535//27371828//27773536//22575960
chr5:150416454-150416455(-) m6A CDS//exon//intron       24284625//24209618//26404942//27773535//27371828//27773536//22575960
chr5:150416923-150416924(-) m6A exon//intron       -
chr5:150416943-150416944(-) m6A exon//intron       -
chr5:150422496-150422497(-) m6A CDS//exon//intron       24284625//24209618//27773535//22575960
chr5:150422508-150422509(-) m6A CDS//exon//intron       24284625//24209618//24981863//27773535//22575960
chr5:150425569-150425570(-) m6A exon//intron       24284625//24209618//24981863//27773535//27773536
chr5:150425617-150425618(-) m6A exon//intron       24284625//24209618//27773535
chr5:150425687-150425688(-) m6A exon//intron       -
chr5:150429393-150429394(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//27773536//22575960
chr5:150429416-150429417(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//27773536//22575960
chr5:150429428-150429429(-) Am CDS//exon       -
chr5:150431754-150431755(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//27773536//22575960
chr5:150436426-150436427(-) m6A CDS       24284625//27773536
chr5:150436457-150436458(-) m6A CDS       24284625//27773536
chr5:150441766-150441767(-) m6A CDS       24284625//27773535//27371828//27773536
chr5:150443238-150443239(-) m6A CDS       24284625//24981863//27773535//27371828//27773536
chr5:150444641-150444642(-) m6A CDS//intron       27773535//27371828//27773536
chr5:150457982-150457983(-) m6A exon//intron       27371828//27773536
chr5:150459703-150459704(-) m6A exon//intron       27371828//27773536
chr5:150459916-150459917(-) m6A 5'UTR//exon//intron       24981863//27773536
chr5:150460633-150460634(-) m6A 5'UTR//intron       24981863//27773536
chr5:150460738-150460739(-) m6A intron       27773536
chr5:150460756-150460757(-) m6A intron       27773536
chr5:150466693-150466694(-) m6A 5'UTR//intron       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate TNIP1
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|K562 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: TNIP1

Evidence Support:


Strong-Evidence RISC-IP
Prediction-Evidence PITA//RNAHybrid
Support Database ViRBase//VmiReg

References:


PMID 20585629 Target region 5'UTR
Source ViRBase//VmiReg Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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