Basic Information:

  VIRBase ID:  

VHID00508140

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          PSME3:  NR_049772     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	PSME3
miRBase Accession/Entrez ID	MIMAT0001581	10197
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	HEL-S-283//Ki//PA28-gamma//PA28G//PA28gamma//REG-GAMMA

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PSME3	chr17:40988663(+) A-I      intronic chr17:40988706(+) A-I      intronic chr17:40988694(+) A-I      intronic chr17:40988689(+) A-I      intronic chr17:40988677(+) A-I      intronic chr17:40987076(+) A-I      intronic chr17:40987582(+) A-I      intronic chr17:40987663(+) A-I      intronic chr17:40987119(+) A-I      intronic chr17:40987563(+) A-I      intronic chr17:40989402(+) A-I      intronic chr17:40987662(+) A-I      intronic chr17:40987659(+) A-I      intronic chr17:40987654(+) A-I      intronic chr17:40988222(+) A-I      intronic chr17:40988121(+) A-I      intronic chr17:40987667(+) A-I      intronic chr17:40987583(+) A-I      intronic chr17:40987073(+) A-I      intronic chr17:40987540(+) A-I      intronic chr17:40987077(+) A-I      intronic chr17:40987692(+) A-I      intronic chr17:40987099(+) A-I      intronic chr17:40987488(+) A-I      intronic chr17:40987557(+) A-I      intronic chr17:40987085(+) A-I      intronic chr17:40987621(+) A-I      intronic chr17:40989146(+) A-I      intronic chr17:40987589(+) A-I      intronic chr17:40987555(+) A-I      intronic chr17:40988122(+) A-I      intronic chr17:40988091(+) A-I      intronic chr17:40987254(+) A-I      intronic chr17:40987565(+) A-I      intronic chr17:40987504(+) A-I      intronic chr17:40987184(+) A-I      intronic chr17:40988134(+) A-I      intronic chr17:40987595(+) A-I      intronic chr17:40992318(+) A-I      intronic chr17:40987487(+) A-I      intronic chr17:40987239(+) A-I      intronic chr17:40987149(+) A-I      intronic chr17:40987648(+) A-I      intronic chr17:40987592(+) A-I      intronic chr17:40988156(+) A-I      intronic chr17:40988196(+) A-I      intronic chr17:40987155(+) A-I      intronic chr17:40988187(+) A-I      intronic chr17:40987539(+) A-I      intronic chr17:40989476(+) A-I      intronic chr17:40988161(+) A-I      intronic chr17:40988054(+) A-I      intronic chr17:40992193(+) A-I      intronic chr17:40987631(+) A-I      intronic chr17:40987564(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PSME3	chr17:40987621(+) A-G intron -    22484847 chr17:40987648(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PSME3	chr17:40985036-40985037(+) m6A exon//intron       24284625//24209618//25456834//24981863//27773536//22608085 chr17:40985630-40985631(+) m6A 5'UTR//exon//intron       24284625//24209618//25456834//22575960//22608085 chr17:40986790-40986791(+) m6A 3'UTR//5'UTR//CDS//exon//intron       26404942 chr17:40986801-40986802(+) m6A 3'UTR//5'UTR//CDS//exon//intron       26404942 chr17:40986883-40986884(+) m6A 3'UTR//CDS//exon//intron       26404942 chr17:40993583-40993584(+) m6A 3'UTR//CDS       25456834//24981863//26404942//27773535//22575960//22608085 chr17:40993616-40993617(+) m6A 3'UTR       25456834//24981863//26404942//27773535//22575960//22608085 chr17:40993637-40993638(+) m6A 3'UTR       25456834//24981863//27773535//22575960//22608085 chr17:40993681-40993682(+) m6A 3'UTR       25456834//24981863//27773535//22575960//22608085 chr17:40993734-40993735(+) m6A 3'UTR       22608085 chr17:40993997-40993998(+) Y 3'UTR       25219674 chr17:40994254-40994255(+) m6A 3'UTR       26404942 chr17:40994268-40994269(+) m6A 3'UTR       26404942 chr17:40994363-40994364(+) m6A 3'UTR       26404942 chr17:40995036-40995037(+) m6A 3'UTR       24284625//26404942//27773535 chr17:40995096-40995097(+) m6A 3'UTR       24981863//27773535 chr17:40995148-40995149(+) m6A 3'UTR       24981863//27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	PSME3	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HeLa-S3 cells     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: PSME3

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.