Basic Information:

  VIRBase ID:  

VHID00508139

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          ALG3:  NR_024534     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	ALG3
miRBase Accession/Entrez ID	MIMAT0001581	10195
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	CDG1D//CDGS4//CDGS6//D16Ertd36e//not//Not56//NOT56L

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ALG3	chr3:183960152-183960153(-) m6A 3'UTR       27773535 chr3:183960225-183960226(-) m6A 3'UTR       27773535 chr3:183960244-183960245(-) m6A 3'UTR       27773535 chr3:183960260-183960261(-) m6A 3'UTR//exon       27773535 chr3:183960279-183960280(-) m6A 3'UTR//exon       24284625//27773535 chr3:183960428-183960429(-) m6A 3'UTR//CDS//exon       24284625//27773535//22575960 chr3:183960815-183960816(-) m6A exon//intron       24981863//27773535 chr3:183960873-183960874(-) m6A exon//intron       27773535 chr3:183961686-183961687(-) m6A 3'UTR//CDS//exon       27773535 chr3:183961693-183961694(-) m6A 3'UTR//CDS//exon       27773535 chr3:183961752-183961753(-) m6A 3'UTR//CDS//exon       27773535 chr3:183962777-183962778(-) m6A exon//intron       27773535 chr3:183962891-183962892(-) m6A exon//intron       27773535 chr3:183966671-183966672(-) m6A CDS//exon//intron       25456834//24981863//26404942//27773536//22575960 chr3:183966791-183966792(-) m6A CDS//intron       25456834//24981863//27773535//22608085 chr3:183966846-183966847(-) m6A CDS//intron       24981863//27773535 chr3:183966886-183966887(-) m6A 5'UTR//intron       24981863//27773535 chr3:183966929-183966930(-) m6A 5'UTR//intron       24284625//24981863//27773535 chr3:183966942-183966943(-) m6A 5'UTR//intron       24284625//24981863//27773535 chr3:183966987-183966988(-) m6A 5'UTR//intron       24981863//27773535 chr3:183967070-183967071(-) m6A 5'UTR       24981863//27773535 chr3:183967079-183967080(-) m6A 5'UTR       24981863//27773535 chr3:183967104-183967105(-) m6A 5'UTR       24981863//27773535 chr3:183967238-183967239(-) m6A 5'UTR       24981863//27773535 chr3:183967298-183967299(-) m6A 5'UTR       24981863//27773535 chr3:183967310-183967311(-) m6A 5'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ALG3	Chromatin K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: ALG3

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.