Basic Information:

  VIRBase ID:  

VHID00508138

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          TSHZ1:  NM_001308210     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	TSHZ1
miRBase Accession/Entrez ID	MIMAT0001581	10194
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	CAA//NY-CO-33//SDCCAG33//TSH1

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TSHZ1	chr18:72949370(+) A-I      intronic chr18:72949392(+) A-I      intronic chr18:72949208(+) A-I      intronic chr18:72949219(+) A-I      intronic chr18:72949947(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TSHZ1	chr18:72923788-72923789(+) m6A 5'UTR//intron       24284625 chr18:72997477-72997478(+) m6A 5'UTR//CDS//exon       24284625//25456834//24981863//22608085 chr18:72997543-72997544(+) m6A CDS//exon       24284625//25456834//24981863//22608085 chr18:72997693-72997694(+) m6A CDS//exon       24284625//24981863//22608085 chr18:72997726-72997727(+) m6A CDS//exon       24284625//24981863//22608085 chr18:72998056-72998057(+) m6A CDS//exon       24284625//24981863//22575960//22608085 chr18:72998110-72998111(+) m6A CDS//exon       24284625//25456834//24981863//22575960//22608085 chr18:72998141-72998142(+) m6A CDS//exon       24284625//25456834//24981863//22575960//22608085 chr18:72998163-72998164(+) m6A CDS//exon       24284625//25456834//24981863//22575960//22608085 chr18:72998191-72998192(+) m6A CDS//exon       24284625//25456834//24981863//22575960//22608085 chr18:72998197-72998198(+) m6A CDS//exon       24284625//25456834//24981863//22575960//22608085 chr18:72998208-72998209(+) m6A CDS//exon       24284625//25456834//24981863//22575960//22608085 chr18:72998300-72998301(+) m6A CDS//exon       24284625//25456834//24981863//22608085 chr18:72998323-72998324(+) m6A CDS//exon       24284625//25456834//24981863//22608085 chr18:72998346-72998347(+) m6A CDS//exon       24284625//25456834//24981863//22608085 chr18:72998399-72998400(+) m6A CDS//exon       24284625//24981863//22608085 chr18:72998434-72998435(+) m6A CDS//exon       24284625//24981863//22608085 chr18:72998521-72998522(+) m6A CDS//exon       24284625//24981863//22608085 chr18:72998734-72998735(+) m6A CDS//exon       24284625//24981863 chr18:72998926-72998927(+) m6A CDS//exon       24284625//25456834//24981863//22608085 chr18:72998980-72998981(+) m6A CDS//exon       24284625//24981863//22608085 chr18:72999010-72999011(+) m6A CDS//exon       24284625//24981863//22608085 chr18:72999332-72999333(+) m6A CDS//exon       24284625//24981863//22608085 chr18:72999428-72999429(+) m6A CDS//exon       24284625//25456834//24981863//27371828//22608085 chr18:72999456-72999457(+) m6A CDS//exon       24284625//25456834//24981863//22608085 chr18:72999479-72999480(+) m6A CDS//exon       24284625//25456834//24981863//22608085 chr18:72999565-72999566(+) m6A CDS//exon       24284625//25456834//24981863//22608085 chr18:72999622-72999623(+) m6A CDS//exon       24284625//24981863//22608085 chr18:72999667-72999668(+) m6A CDS//exon       24284625//24981863//22608085 chr18:72999709-72999710(+) m6A CDS//exon       24284625//24981863//22608085 chr18:72999775-72999776(+) m6A CDS//exon       24284625//24981863//22608085 chr18:72999811-72999812(+) m6A CDS//exon       24284625//24981863//22608085 chr18:72999877-72999878(+) m6A CDS//exon       24284625//24981863//22608085 chr18:72999898-72999899(+) m6A CDS//exon       24284625//24981863//22608085 chr18:73000039-73000040(+) m6A CDS//exon       24284625//24981863//22608085 chr18:73000092-73000093(+) m6A CDS//exon       24284625//24981863//22608085 chr18:73000120-73000121(+) m6A CDS//exon       24284625//25456834//24981863//22608085 chr18:73000221-73000222(+) m6A CDS//exon       24284625//25456834//24981863//22608085 chr18:73000246-73000247(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr18:73000252-73000253(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr18:73000302-73000303(+) m6A CDS//exon       24284625//25456834//24981863//22575960//22608085 chr18:73000332-73000333(+) m6A CDS//exon       24284625//25456834//24981863//22575960//22608085 chr18:73000351-73000352(+) Y CDS//exon       26075521 chr18:73000391-73000392(+) m6A CDS//exon       24284625//24981863//22575960//22608085 chr18:73000425-73000426(+) m6A CDS//exon       24284625//24981863//22575960//22608085 chr18:73000456-73000457(+) m6A CDS//exon       24284625//24209618//24981863//22575960//22608085 chr18:73000494-73000495(+) m6A CDS//exon       24284625//24209618//24981863//22575960//22608085 chr18:73000520-73000521(+) m6A CDS//exon       24284625//24209618//24981863//22575960//22608085 chr18:73000536-73000537(+) m6A CDS//exon       24284625//24209618//24981863//22575960//22608085 chr18:73000558-73000559(+) m6A CDS//exon       24284625//24209618//24981863//22575960//22608085 chr18:73000589-73000590(+) m6A CDS//exon       24284625//24209618//24981863//22575960//22608085 chr18:73000614-73000615(+) m6A 3'UTR//exon       24284625//24209618//24981863//22575960//22608085 chr18:73000622-73000623(+) m6A 3'UTR//exon       24284625//24981863//22575960//22608085 chr18:73000710-73000711(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr18:73000874-73000875(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr18:73000897-73000898(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr18:73000920-73000921(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr18:73000964-73000965(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr18:73000995-73000996(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr18:73001088-73001089(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr18:73001095-73001096(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr18:73001134-73001135(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr18:73001150-73001151(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr18:73001189-73001190(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr18:73001196-73001197(+) Gm 3'UTR//exon       - chr18:73001228-73001229(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr18:73001235-73001236(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr18:73001273-73001274(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr18:73001639-73001640(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr18:73001690-73001691(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr18:73001736-73001737(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr18:73001744-73001745(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr18:73001764-73001765(+) m6A 3'UTR//exon       24284625//24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	TSHZ1	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HeLa-S3 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: TSHZ1

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.